“a borderline significant trend”

1 Mean difference −0.62 × 10 − 3 (95% CI −1.25 to 0.01) × 10 − 3 , p = 0.06, indicating a borderline significant trend favoring darbepoetin; Fig. 2 Mean difference −0.83 × 10 − 3 (95% CI −1.46 to −0.19) × 10 − 3 , p = 0.01, demonstrating a statistically significant advantage for darbepoetin Fig. 3 Mean difference −1.45 × 10 − 3 (95% CI −2.06 to −0.83) × 10 − 3 , p < 0.00001, indicating a highly significant superiority of darbepoetin Collectively, these findings suggest that, under most study conditions, darbepoetin is likely to be more effective than short-acting epoetin in achieving or maintaining target hemoglobin concentrations.

Patients with low-proliferative C2 tumors, as determined by SSP-Ki67, showed a borderline significant trend toward improved prognosis in univariable analysis (SSP-Ki67: HR = 0.104, 95 % CI: 0.011–1.006, Log-rank p = 0.017; Fig. 5 ).

Yet, we observed a borderline significant trend towards higher prevalence in later years for MSM in our sensitivity analysis ( p = 0.04) (Appendix Table S7 ).

Moreover, our results could be conservative because the 131 threatened species in our study show a borderline significant trend towards having more missing traits than non-threatened species (Kruskal–Wallis test: p = 0.04, χ 2 = 19.96, df = 2; Supplementary Methods .

A borderline significant trend toward increased risk was observed for schizophrenia (hazard ratio [HR] = 1.82, 95% confidence interval [CI] = 1.01–3.27, P = .0410) and suicide-related outcomes (HR = 1.38, 95% CI = 0.76–2.51, P = .2858); however, these associations did not remain significant after correction for multiple comparisons ( Figure 2 ).

An aggregate variable, indicating the average citation frequency of a paper from the first and last author combined, shows a borderline significant trend towards OA authors being cited more often per paper (OA = 12.31 versus non-OA = 10.02; Z = 2.001, p = 0.045).

In this case, the cumulative incidence of discontinuation was higher in migrants across all categories, including a borderline significant trend towards higher VF (aHR 3.51, 95% CI 0.95–12.98, p = 0.045), but with substantial uncertainty given the small number of failures. 3.4 On‐Label Analysis The results of the secondary analysis, including only PWH in whom the prescription was in accordance with the technical sheet, and excluding those who had NNRTI or INSTI mutations, are presented in File S4, Tables S4.1 − S4.4 and Figure S4 . 4 Discussion In our study, migrant PWH switching to LAI CAB+RPV exhibited low VF rates, comparable to those observed in pivotal clinical trials.

A positive association between GL and high MBD emerged in the comparison between highest and lowest quintiles in the crude model (OR = 1.50; 95%CI 1.07–2.11), and resulted strengthened in the adjusted model (OR = 1.73; 95%CI 1.13–2.67), with a borderline significant trend over quintiles (p = 0.048).

For Confident , there was only a borderline significant trend ( p =0.049).

Finally, a non-significant trend for zinc deficiency was found in PPI users (81.2 ± 13.9 versus 87.0 ± 12.7, p = 0.08) and also a borderline significant trend for lower sodium levels in PPI users (139.8 ± 3.8 versus 141.8 ± 4.6, p = 0.05).

In contrast, heavy physical labor showed only a borderline significant trend ( P = 0.05, OR = 6.90), but its substantial effect size warranted inclusion in the model, suggesting a potential clinical relevance that merits further investigation.

In female COPD patients, pulmonary artery (PA) diameters were higher than in controls, showing a borderline significant trend ( p = 0.050), while total lung volume negatively correlated with Vena Cava Superior (VCS) diameter ( p < 0.05).

The sensitivity analysis, including studies where the effect size was approximated from median and interquartile range, showed a borderline significant trend towards higher image quality for DLR (summary effect size of 1.38, 95% confidence interval 0.00–2.04, p = 0.05, df = 32).

Food Patterns The Jonckheere–Terpstra test ( Table 2 ) revealed a significant increasing trend across neuropathy severity for the Western/fast-food dietary pattern (Z = 2.24, p = 0.03) and refined grains and starches pattern (Z = 1.99, p = 0.04) and a borderline significant trend for the alcohol and animal fat pattern (Z = 1.92, p = 0.05).

While the weighted median method suggested a borderline significant trend ( p < 0.05), MR-Egger analysis did not confirm this association.

Length of hospital stay showed a borderline significant trend favoring PPF (11.00 ± 6.99 vs. 16.27 ± 13.03 days, p = 0.05).

No significant trend over time was observed for the national (p=0.09) studies and a borderline significant trend over time was observed for the regional studies (p=0.05).

A borderline significant trend toward increased SAE risk was observed (OR = 3.36, P = 0.05).

Meanwhile, studies with higher proportions of patients with AFP > 400 showed a borderline significant trend toward elevated HRs for PFS ( p = 0.05).

Interestingly, the analysis at three months highlighted a borderline significant trend only for DBP (–2.2 (–4.5 to 0.0); p = 0.05) among the internet-based intervention participants [ 33 ], while the results at the 12-month follow-up showed significant improvements in DBP (–1.8 (–0.2 to –3.3); p < 0.03) for all participants.

For EPA + DHA intake, the association approached but did not reach statistical significance for all-cause mortality ( P = 0.055), while showing a borderline significant trend for cardiovascular mortality ( P = 0.050), as depicted in Fig.

In addition, ki67 mRNA level was lower in hNESPCs from NP as compared to controls in P1 (1.5-fold, a borderline significant trend, p = 0.05) and P2 (2.1-fold, approaching borderline of significance, p = 0.07) ( Figure 3A ).

There was also a borderline significant trend toward an increased objective RR in patients with grade 3 to 4 immune-related adverse events (4 of 15 [27%] vs 2 of 36 [6%]; P < .05).

Regarding the number of axillary lymphadenectomies (ALND) that were performed ( Table 2 ), a borderline significant trend (p = 0.05) was observed between ALND in the OSNA group (n = 51/148, 34%) and in the classical H&E-based IHC group (n = 37/153, 24%).

Regarding peripheral changes in endothelial and inflammatory parameters (Table 5 ), only the E-selectin changes showed a borderline significant trend of decrease between the LSB and LSB + G treatments ( P = 0.051).