Excerpts

For secondary endpoints, at week 12, 82% of subjects in the treatment group achieved complete closure (18 of 22) versus 53% in the control group (9 of 17), with a trend towards significance ( p = 0.053).

Although the time course of left ventricular ejection fraction (LVEF) showed a trend toward reduction in the sham compared to the V-V ECMO group after the end of the experiments, the difference failed to reach statistical significance ( p = 0.053). 2.3.

However, it should be mentioned that borderline significance was obtained for alleles of POLG c.-1370T > A (rs1054875) ( p = 0.053). 2.4.

In contrast, including plasma samples from BC patients in the statistic tests introduced a certain degree of noise and the mutation c.742C>T in sample 079MS was not detected despite being close to significance ( p -value = 0.053) ( Table S4 ).

Among dietary and lifestyle variables, only flavonoid intake showed nominal interaction with GRS ( p = 0.037), while fat intake showed borderline significance ( p = 0.053); neither passed the Bonferroni correction.

Expression showed a near-significant increase compared with naïve striatum ( p = 0.053) but not contralateral striatum ( p = 0.22) ( Figure 1 B).

Our results do not support this, because a nearly significant ( p = 0.053) elevation of Adcyap1 mRNA expression occurred in the insular cortex that fits well with the observations of Broome et al.

Notably, when comparing ether-lipid-deficient mice against WT, wall stress at end-diastole was significantly increased at the septal wall ( Figure 3 C) and almost reached statistical significance for the free ventricle wall ( p = 0.053; Figure 3 D).

Although not statistically significant, higher TGF-β levels at three months post-treatment initiation showed a trend toward association with worse outcomes [mean (standard deviation) 43.2 (28.2) pg/mL vs. 29.6 (46.9) pg/mL, p = 0.053] ( Figure 5 ).

Active smoking showed a trend towards increased risk (OR = 2.68, 95% CI: 0.99–7.28; p = 0.053), though this was not statistically significant.

The results show that the average NE concentration was higher after WECS treatment, at the margin of statistical significance ( p = 0.0531) ( Figure 4 A).

In particular, miR-101 ( p -value = 0.0023) and miR-26b ( p -value = 0.0016) expression levels were significantly lower in tumors than in normal tissues, while miR-200c showed borderline significance ( p -value = 0.0537). 2.3. miR-101, miR-26b, and miR-200c are Confirmed to be Significantly Downregulated in IGC The levels of the 3 miRs differentially expressed in the exploratory case series were analyzed in the case series of 33 IGC patients by RT-qPCR using specific TaqMan gene expression assays.

Vglut2-cKO mice showed a trend of increased episode number of wakefulness ( p = 0.0539) and NREMS ( p = 0.0786) ( Figure 5 C), whereas the average episode duration of NREMS was shorter in Vglut2-cKO mice than in WT littermates ( Figure 5 D).

No other significant differences were found (except for a borderline significance ( p = 0.054) at 10 −7 M fentanyl).

While there was a strong trend toward a prolonged intubation ( p = 0.054), a prolonged ICU stay was significantly more likely in the higher initial AP drop cohort (31.9 vs. 48.0%; p = 0.004).

The baseline concentration of the biomarker higher than 212 μg·mL −1 was significantly associated with increased risk of disease progression (PFS HR 2.5 (1–6), p -value = 0.042, Figure 3 F), and there was a borderline significant association with increased risk of death (OS HR 2.6 (0.98–7.1), p -value = 0.054, Figure 3 H).

In women, however, the Friedman ANOVA test did not show statistically significant differences, although the p -value approached significance ( p = 0.054), with Kendall’s coefficient of concordance at 0.18.

Additionally, there was a marginally significant increase in I-FABP levels in lean patients when compared to non-lean individuals ( p = 0.054, Figure 7 a).

We observed a statistically significant association for the GC rs7041 polymorphism in the additive ( p = 0.028) and allelic ( p = 0.031) models, and a tendency toward statistical significance in the dominant ( p = 0.054) and genotypic ( p = 0.088) models ( Table S5 ).

While OGA expression showed an increasing trend in aortic lysates from hyperglycemic vs. non-hyperglycemic smOGT WT mice, this difference did not reach statistical significance ( p = 0.054).

Although the intergroup comparison revealed no significant group differences, the direct comparison of steroid-sensitive and steroid-refractory samples showed a trend towards higher CD4 + CD25 + CD127 low T reg repertoire diversity ( p = 0.054; CD4 + T con , p = 0.114) linked to steroid sensitivity.

The pre-administration baseline AαVal541 level of the AATD patients before they received their first AAT augmentation therapy showed no correlation with baseline pulmonary function, although diffusion capacity (KCO) showed a trend to a negative correlation with baseline AαVal541 level (Spearman’s correlation coefficient—0.624, p = 0.054). 2.4.

The other two transcripts were close to significance, ARL17A--KANSL1 and CC2D1A--CPNE8 , p = 0.054 and p = 0.074, respectively ( Supplementary Table S4 ). 2.6.

CasHyd encapsulated in a coated oral delivery vehicle (pellets) showed a trend towards an increase in food intake in female rats ( p = 0.054), and male rats ( p = 0.097) at the 6-h timepoint, although overall no significant differences are noted.

High staining patterns of ER-β1 conferred a marginally significant protective effect against developing metastases in the univariable model (HR 0.39, 95% CI 0.15–1.01, Mantel–Cox test p = 0.054, log-rank test p = 0.045, Figure 2 ), something that did not apply in the multivariable Cox models ( Table 2 ).