Excerpts

Nominally significant associations ( p < 0.05) were observed between higher maternal levels of IL-8 during early pregnancy with lower gross motor (β: −0.902, 95%CI: −1.697, −0.107, p = 0.026) and fine motor (β: −0.880, 95%CI: −1.500, −0.259, p = 0.006) skills score at age one.

The resulting p -values were considered nominally significant at p < 0.05.

When we assessed glycolytic ECAR flux, non-glycolytic flux (NG-ECAR) was reduced in hypoxia treated astrocytes but just failed to reach significance ( p = 0.0502, unpaired t-test) ( Figure 8 D).

The result of the Chi -square test didn’t support the dependency of Pinb2-7D or Pinb2-7B on kernel hardness, although the association results of Pinb2-7D approached significance ( P = 0.0503).

Interestingly, expression of TGM2, COL1A1, COL1A22 were not induced in the ex vivo experiments but significantly (in the case of COL1A1 with p = 0.0507 almost significantly) induced in the in vivo situation.

Tetranor-PGEM levels were also slightly increased (1.18-fold) after 4 weeks of tranilast administration with borderline significance ( p = 0.0507).

A strong trend for an increase in this measure was found in non-stressed C57BL/6 mice compared to non-stressed CBA mice ( p = 0.0507).

Males reached borderline significance, with the TC genotype being more highly represented in the CD subtype ( p = 0.051), despite reaching overall model significance ( p = 0.007).

In addition, no correlations were observed between CGRP and TRPV1, however, a trend towards significance ( r = 0.454; p = 0.051; n = 19) was observed between SP and TRPV1 protein levels in DDD patients. 2.6.

However, we observed borderline significant higher IL-17C levels in patients with CVD when PASI ≤ 10 (3.27 vs. 2.82, p = 0.051, Figure 5 , lower right). 3.

Most importantly, a significant association of methylated PCDH8 level to tumor maximal diameter at diagnosis (R s = 0.35; p = 0.028) as well as borderline significance to tumor volume (R s = 0.32; p = 0.051) at diagnosis was identified ( Figure 3 A,B).

Interestingly the co-culture group showed a trend of upregulation of the basal-specific epidermal marker KRT14 with 0.4 folds over the 100% group ( p -value = 0.051; Figure 2 g) while it kept the same upregulation pattern in comparison to the 0% group ( p -value = 0.0005; Figure 2 g).

The overall model indicated borderline significance (likelihood ratio test, p = 0.051).

Of the nine patients included in the study, ESWT improved healing in seven, as assessed by a decreased measurement of wound area in the patient at baseline before ESWT, and at two weeks post-shockwave therapy ( Figure 1 A), although this decrease did not quite reach statistical significance (mean values ± SEM, pre-treatment 93.53 ± 38.61; post-treatment 88.23 ± 37.40; p = 0.051).

Similarly, α-smooth muscle actin (ACTA2) expression displayed a strong trend toward downregulation in the LV ( p = 0.051; Figure 5 E), with numerically lower values also observed in the RV (though not reaching statistical significance).

However, after the inclusion of NT-proBNP (Model B), the association of GDF15 with all-cause mortality was attenuated, reaching borderline significance (HR 2.61; 95% CI: (0.99–6.87), p = 0.051), whereas NT-proBNP retained significance (HR 1.11; 95% CI: (1–1.22), p = 0.044) ( Table S2 ). 2.4.

TMEV-infected Mmp12 −/− mice showed transiently reduced astrogliosis in association with a strong trend ( p = 0.051) for a reduced density of activated/reactive microglia/macrophages compared with wild-type mice at 28 dpi.

There was no change in RAD51 expression and a slight decrease in CHK1 in all BRCA1 clones, but only reaching marginal significance in BRCA1 exon-9.2 ( p = 0.051).

The decrease in 95–100 kDa full-length species of ACE2 was also correlated significantly with GFAP (r = 0.31; p = 0.043), T-tau (r= 0.46; p = 0.002) and was close to achieving significance for NfL (r = 0.30; p = 0.051).

The zinc finger transcription factor early growth response 1 (Egr1) was also downregulated in the old HCR and old LCR ( Figure 1 B), but downregulation in old LCR compared to young LCR just missed significance after Bonferroni–Holm correction ( p = 0.051).

When analyzed independently of the control group, pooled samples from the two groups receiving malonate showed a trend of having higher succinate concentrations than those receiving RIC alone (repeated measures ANOVA, p = 0.051 for interaction), and significantly reduced levels of fumarate (repeated measures ANOVA, p = 0.014 for interaction and p < 0.001 for group allocation) and malate (repeated measures ANOVA, p = 0.019 for group allocation).

For example, the manipulation of genes such as Actn3 results in nearly significant fibre type changes (e.g., p = 0.051 in the spinalis) [ 76 ] and this is an issue because of the limited p -values [ 77 ] used.

Immunoglobulin T membrane-bound form ( igt-m ) exhibited the same trend in the 48 h post-feeding sampling time, although not strictly significant ( p = 0.051).

However, after 12 months, the active group showed a trend toward a reduction in TRACP-5b levels compared to the placebo group ( p = 0.051, Figure 2 B).

This difference was significantly different in the proliferative phase (post hoc analysis p = 0.045) and borderline significant in the secretory phase ( p = 0.051).