Barely Significant

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There is an increasing trend in the last five years to use translational large animal models, such as pigs and Rhesus monkeys, to simulate the real-life intensive care received by EPIs, including but not limited to antenatal steroids, surfactant, caffeine, protective ventilation strategies, and nutritional support [ 102 , 103 , 104 ].
Finally, based on PFS, we filtered and arranged 29 targets with inclusion criteria: (1) response AUC ≥ 0.6 and PFS ≤ 0.05 in both TR and ET cohorts ( AKT1S1 , NSL1 , ESRRA , TMEM81 , CKB , SGEF ); (2) statistical significance in PFS/OS of two cohorts ( KRT19 ); (3) borderline significance between CR and PD ( SCG5 , CEACAM1 , ALOX12B ) and seven targets with inclusion criteria; (4) statistical significance in PFS of TR or ET cohort.
Downregulation of miRNA-181a and overexpression of miR-132, miR-143, miR-145 and miR-155 in serum may be significant in SSc in the context of biomarkers. systemic sclerosis microRNA Polpharma Scientific Foundation This work was supported by a grant from the Polpharma Scientific Foundation. pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement yes pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY 1.