Excerpts

We have also noticed a clear trend toward upregulation for Itgb1 in WT astrocytes, although this result did not reach statistical significance.

However, TGFβRII mRNA expression showed an increasing trend after tofacitinib intervention but did not reach statistical difference ( Supplementary Figure 3A ).

In our previous report from the EpiPath cohort, multiple correction testing during our survey of the complete immune system meant that NK cells only narrowly missed significance ( 18 ), and the only other comparable study did not investigate NK cells ( 64 , 112 ).

Unfortunately, in our previous report, this result was highly significant prior to, but not after, post-hoc multiple testing correction ( 18 ) The limitations of our pre-clinical study include potential litter effects and the absence of a clear HPA axis phenotype.

Migration toward the anode showed a trend of increased migration by increasing applied field.

In the case of the rest of cytokines, we did not find a significant relationship, but a clear trend ( Supplementary Figure 2 ).

Surprisingly, although the dramatically disturbed T h 1/T h 2/T h 17 balance in heroin addicts at the AW stage has been mostly restored to the baseline around one year after the initiation of abstinence, the levels of cytokines of T h 1 (IL-2, adj.p = 0.0467; TNF-α, adj.p = 3.45E-03), T h 2 (IL-4, adj.p = 0.06; IL-10, adj.p = 0.0461), and T h 17 (IL-17A, adj.p = 5.41E-03) remained elevated in PW heroin subjects relative to HCs with a statistical significance or a considerable trend toward significance.

CD8 + T central memory cells (CD8 + T CM ) showed a trend that did not quite reach statistical significance after Benjamini-Hochberg correction (FDR=0.11) ( Figure 6F ).

GO Analysis of TO-GCN After SARS-CoV-2 Infection The genes with peak gene expression at the first time point and a decreasing trend over time were defined as the initial node of TO-GCN.

This may be significant because loss of Trem2 has been shown to increase IFN-I signaling ( 97 ).

Similar to the infection-naïve individuals, the anti-S antibody titres showed a decreasing trend after the second vaccine dose at weeks 6 and 7 ( Figure 4A ).

An increasing trend of the cumulative distribution function (CDF) value was considered as an indicator of an outstanding clustering ( Figures S1A–F ).

Of all markers tested the lymph node homing receptor CCR7 and CD15s (sialyl lewis x, expressed by Tregs in sarcoidosis) were lower in MulTreg, whilst gut homing integrin beta 7 (β 7 ) showed a trend for increased expression in MulTreg according to both MFI and frequency ( Figures 2G–I and S2C ).

Whilst both cell products showed a clear trend towards inhibition of IFNγ, TNFα and IL-17A in Flu-HA responses this was only significant in MulTreg co-cultures, however, no difference was seen in inhibition of IL-13 ( Figure 3F ).

48.56 ± 11.27 years, p = .0913) and showed a statistical trend toward significance.

Differences were considered significant when p-values were less than 0.05, and p <.1 was described as a trend toward significance.

Il10 -/- mice showed a trend towards greater IFNγ production compared to B6 mice after both polyclonal stimulation ( Figures 4G, H ) and more strikingly directly ex vivo ( Figures 4I, J ).

There was a clear trend in differences between BLXA 4 and the no-rinse group, however, they were not statistically significant ( P =0.299 and P =0.111).

Combined urine complement products could increase the predictive ability compared with crescents alone from 0.904 to 0.944 ( p = 0.062) with borderline significance.

Similar results can be observed with the normal samples, although due to a very small sample size, the p -values were slightly significant, especially for the diversity measure ( Figures 2A, B ).

The frequency of mature (CD3 high CD1a low ) CD8-single-positive thymocytes showed a trend for increase with the surge of the cTEC/mTEC ratio, whereas the opposite was seen for the mature CD4-single-positive counterpart ( Figures 5F, G ).

Both patients with chikungunya and with OAFD had an increasing trend in the levels of CXCL9 over time.

On the other hand, patients with chikungunya presented a decreasing trend in the levels of CXCL8, CCL2, CCL5, CXCL10, and IL-6 after 1 or 2-3 DPSO, but patients with OAFD did not follow this pattern.

Although there was no significant difference in growth kinetics between E218A virus and WT virus, the growth of E218A virus showed a trend of slowing down significantly 48 h after infection ( Figures 3D, E ) .

PGD in the lung allograft was associated with an increase in the epigenetic age, and older methylation age showed a trend toward poorer outcomes.