Excerpts

Data with marginal significance (p value <0.1) were also discussed. 3 Results 3.1 Phenotypic characterization of peripheral blood monocytes in CRC First, we examined the differences in peripheral blood monocyte major subpopulations between CRC (CC plus RC) patients and healthy donors.

The MVA-150 group also showed a trend (p=0.1) for delay in acquisition of SHIV infection with an estimated vaccine efficacy of 57%.

Enteritidis -Challenged Laying Hens During the post-salmonella challenge period (from day 21 to day 42), compared with the CON group, the egg production of SCON hens had a decreasing trend (0.05 < P < 0.1, Table 1 ).

p ≤ 0.05 was considered as significant difference, p ≤ 0.01 was considered as extremely significant difference, and 0.05 ≤ p < 0.10 was considered as trend.

Recombinant TLR4 alone had no notable impact, the anti-CD14 antibody suggested a mild trend toward ( p ~ 0.1) inhibition of uptake, whereas recombinant MD-2 inhibited ( p ≤ 0.045) only HAdV-D26 ( Figure S3A ).

Consistent with a more effective bacterial elimination in cerebellum, animals pre-treated with PEA showed a trend toward lower chemokine levels compared to controls ( P = 0.10, multivariate rank-sum test followed by Holm–Bonferroni correction, Figure 4D ).

Although pregnancy status was not significantly associated with either measure of constitutive immunity in 2012, we observed an interesting trend in 2013, whereby sheep that were pregnant had lower bactericidal capacity than those that were not pregnant ( P < 0.1).

First, univariate Cox regression identified three variables with a trend toward significance for PFS (P < 0.1): BMI, HALP, and SII; and three variables for OS (P < 0.05): location, HALP, and post-treatment SII changes.

Results Pro-inflammatory CCL-2 was higher in APS-2 patients than in controls (p = 0.001), whereas IL-6 showed a trend – (p = 0.1).

Specifically, a subset of NK cells (CD16 + CD56 hi ) showed a trend toward increasing expression of HLA-DR after 8 weeks and after the washout period ( p < 0.1, Figure 4 B).

P < 0.05 was considered as “significant” (*), p < 0.01 as “highly significant” (**), p < 0.1 as “tendency (TD)”.

None of the bacterial strains increased CFU/ml over 2 h in cell culture; while there was a possible trend for living Δ pde2 and Δ pde1Δpde2 mutants to decrease more than WT (suggesting poor stress responses), this did not reach statistical significance ( P = 0.10 across groups in one-way ANOVA).

However, PHEN treatment showed a trend ( p < 0.1) toward reduced TNF-α production compared with VEH-treated arthritic rats (Figure 3 C) and PT treatment significantly inhibited TNF-α release compared with VEH- or TERB-treated arthritic rats ( p < 0.05) (Figure 3 C).

Further analysis of the data by AUC revealed that during the immunization phase, the expression of CCR7 showed a trend (p ≤ 0.1) to increase in cT FH 2 but not cT FH 1 or cT FH 17 in TD compared with NoTD participants ( Supplementary Figures S5A-C ).

The multivariate analysis included the factors that in the previous univariate analysis were associated with thrombotic events significantly or close to significance (p-value <0.1).

As discussed above regarding the T EM data, although the tSNE graphs show striking differences in certain clusters (e.g., 1 and 5), only trends which did reach statistical significance ( p < 0.05), or trend toward significance ( p < 0.1), were observed for differences in these clusters between age groups.

We tested the significances of the explanatory variables both in full models and in minimum adequate models (MAMs; i.e., models with all terms either significant, P ≤ 0.05, or marginally non-significant, P < 0.10) that were obtained by backward eliminations of particular terms from the full model.

Similar to LPMC CD8 + MAIT, DN MAIT subset showed a trend to be correlated ( r = 0.25, P = 0.10) with age (Figure S2B in Supplementary Material).

In addition, CVID patients showed a trend towards different composition of the bacterial species (p=0.103, ANOSIM (Analysis of similarities); Figure 2B left) resulting from differences in numbers rather than abundances of bacterial species ( Table S3 ).

Four out of ninety-nine lncRNAs, namely NRIR, PSMB8-AS1, RP5-1091N2.9, and RP11-24F11.2, were expressed at significantly higher levels in at least two groups of SSc patients as compared to their respective healthy donors in the “definite SSc” cohort ( Figure 3A ), whereas only NRIR was significantly up-regulated in ncSSc and showed a trend in eaSSc (FC = 1.30, p = 0.104) in the “non-fibrotic” cohort ( Figure 3B ).

The infected HFD mice showed a trend of relatively higher generation of NETs in their lungs at 6 DPI ( P = 0.104) and 10 DPI ( P = 0.111) (Figures 4 C,D).

Compared to the naïve control group, group 2 (Alum/CP15) showed the best protection against weight loss (P=0.004), while group 1 (Alum) showed a trend of protection (P=0.11, Figure 1B ).

Non-responders to the vaccine showed a trend toward increased naïve B cell percentage (β= 12.50, p=0.11) and decreased total memory B cell percentage (β=-12.54, p=0.080).

However, on IAV-specific CD8 + T cells, only a small trend of increased CXCR3 expression on (p=0.11) was observed in CMV - compared to CMV + individuals ( Supplementary Figure 3B ) early after IAV infection.

[ 18 F]FDG PET/CT imaging showed a trend for increased [ 18 F]FDG-uptake in the periodontium [mean standard uptake value (SUV mean ), p=0.11] and in femur bone marrow (SUV mean , p=0.06), but no differences were observed for vascular inflammation.