Excerpts

The CD subgroup did not differ significantly from baseline overall, though active CD showed a trend toward elevation ( p = 0.0864).

GPR109A, although not significant, showed a strong trend of upregulation with higher NLRP3 expression (p=0.087).

White blood cell count (WBC) and neutrophil percentage (N%) showed marginal significance in the training cohort ( P = 0.088 and P = 0.040, respectively), but these differences were not statistically significant in the validation cohort ( P > 0.05).

Along the same line, transcription of the risk genes KIR3DL10 and KIR3DS02 is in both cases associated with shorter survival times ( KIR3S02 : HR 2.96, p = 0.043: KIR3DL10: borderline significance HR 1.96, p = 0.088), and with a decrease in NK cell numbers ( KIR3DL10 : −180.5, p = 0.017; KIR3DS02 : borderline significance −169.0, p = 0.065).

Patients with PAD had no significant difference in total circulating monocytes when compared to AAA patients, but also showed a statistical trend for elevated levels in comparison to the healthy control collective (528 vs 488 N/μl, p = 0.088).

Conversely, TCI high showed a trend for a better 2-year DFS: 45% ± 6% for TCI low, 49% ± 6% for TCI intermediate, and 65% ± 6% for TCI high ( p = 0.088).

However, in the propensity score-matched sintilimab subgroup, univariate analysis indicated only a borderline significant association (HR:1.53, 95% CI: 0.94-2.49, P = 0.088), which lost statistical significance after multivariable adjustment (HR:1.50, 95% CI: 0.92-2.45, P = 0.101).This discrepancy may be attributed to several factors: First, while propensity score matching balanced known prognostic variables, there may be unmeasured confounding variables, unmeasured confounders including tumor microenvironment heterogeneity, genomic profiles, or lifestyle differences may persist.

We also performed PERMANOVA test to explore the differences of beta diversity between groups, which revealed a marginally significant difference between RAI and nonRAI subgroups (R 2 = 0.0181, P = 0.0882).

ALλ(CLA) amyloidomas contained significantly more CXCL10, GM-CSF (granulocyte monocyte-colony stimulating factor), and IL-10, with more expression of CCL5 trending towards significance ( p =0.0882) ( Figure 5 ).

Stimulation with rmCIRP increased the protein expression of IL-1β in WT pulmonary fibroblasts by 2.5 fold, which showed a trend towards statistical significance (p=0.0884, Figure 1F ).

In contrast, SLC27A1 expression was positively correlated with serum creatinine (Pearson r = 0.467, P = 0.038; Figure 10c ) and showed a trend toward correlation with blood urea nitrogen (Pearson r = 0.390, P = 0.089), while no significant association was found with 24-hour proteinuria ( P > 0.05).

As showed in Figure 2D , ssGSEA analysis further demonstrated an increasing trend in the ferroptosis score in the KD group (Driver-Suppressor, p = 0.089), and a significantly lower score for the Suppressor gene set (Suppressor, p = 0.007), while the Driver gene set scores were comparable between groups (Driver, p = 0.25).

Additionally, the presence of tumor margin protrusions during the portal venous phase showed a trend toward statistical significance (OR = 5.94, P = 0.089).

However, trends approaching significance were detected between higher VEGF levels and the presence of hyperpigmentation (median 6,099 pg/ml vs. 2,741 pg/ml, P = 0.09), hemangiomas (6,921 pg/ml vs. 5,243 pg/m L , P = 0.06), and hypertrichosis (6,328 pg/ml vs . 3,896 pg/ml, P = 0.06).

Although not statistically significant, the analysis of studies grouped in peri-implantitis showed a trend towards significance (p=0.09).

There was a weak trend for negative correlation between level of IgA to beta-lactoglobulin and number of IgA bands to B. breve strain DSM20213 (r=-0.18; p=0.09), as well as and between level of IgG to beta-lactoglobulin and number of IgA bands to B. breve strain DSM20213 (r=-0.21; p=0.05).

However, patients achieving NK and CD8 IR showed a trend toward higher relapse rates (35% vs 16%, P =0.09 and 36% vs 15%, P=0.08 , respectively).

The interaction between HS and Se was extremely significant for TNF-α and IL-6 ( P < 0.01), and had a significant trend on IL-1β ( P = 0.09).

Similar to NKG2E , high-level expression of NKG2C showed a trend (p=0.09) toward being associated with prolonged survival of high-risk neuroblastoma patients (data not shown).

Long-term (∼3-months) glycemic control, as measured by HbA1c, showed a trend toward being lower% ( p = 0.09, 95% CI −0.02, 0.26, d = 0.60) and mmol/mol ( p = 0.061, 95% CI −0.08, 2.88, d = 0.68), while short-term (∼6 weeks) glycemic control, as measured by GSP reduced by 25% ( p = 0.044, 95% CI 9.8, 109.8, d = 0.64).

The model predicting worst pruritus intensity at the 6MFU was not quite significant (F(4,21) = 2.25, p = 0.09).

Although the naked virus did not show a significant difference compared to the control group (p=0.3791), the VSV-IFNβ-infected mBOECs group showed a decreasing trend of lung tumor burden compared to the control (p=0.09).

When comparing MFI levels, PTB at diagnosis and LTBI showed a trend of increased levels of COX-2 compared to PTB at end-of treatment (p = 0.09 and p = 0.08, respectively), while there were no differences in levels of EP2 and 5-LOX ( Figure 3C ).

miRNA EV expression was lower at D14 in patients who later developed aGvHD compared with those who did not and this was significant for miR-199 ( p = 0.008), miR-93* ( p = 0.001), and approaching significance for miR-423 ( p = 0.09) (Figure 4 A).

Similarly, CXCL12 showed elevated production in TMEV-IDD (mean = 352 pg/ml) compared to sham (mean = 193 pg/ml) although results were only near to significance ( p = 0.09).