Excerpts

Moreover, P-CON and AS-CA significantly decreased the diarrhea rate and increased the fecal score of piglets compared to the CON group ( P < 0.05), while the diarrhea rate in the AS-TF group showed a decreasing trend ( P = 0.074).

Other inflammatory indicators, such as NLR, approached significance (p=0.074), further supporting the impact of low-grade inflammation.

In the final time-to-event multivariable model (including those covariates with p < 0.1 in the univariate model), no individual parameter demonstrated an independent association with mortality, though the ASV metric approached significance (HR 1.51, 95%CI: 0.96 – 2.38, p = 0.074) ( Table 2 ) .

In the present work, we could find a clear trend (p = 0.0742) towards an increase of iEOS in SEA vs.

Treatment with mSCF CAR did not result in a significant survival benefit under the conditions tested, whereas hSCF sBite γδ T cells showed a trend towards survival enhancement ( Figure 8E , p = 0.075).

In a further subgroup analysis, patients with permanent treatment discontinuation due to immune-related toxicity (40/41 were evaluable) showed a trend toward prolonged OS, albeit without statistical significance (p=0.075, Supplementary Figure S2 ). 4.

Unlike the lipidomic profile, none of the immune markers reached statistical significance (p-value <0.050, q-value <0.200), although TNF-RI showed a marginal trend (HR = 3.83; p-value =0.075, q-value =0.286).

The analysis revealed that age, tumor stage, surgery, and chemotherapy may serve as independent risk factors for OS (all P < 0.05), while tumor site approached borderline significance (P=0.075). 3.4 Survival analysis We further evaluated the survival prognosis of this tumor.

For CYT, we observed almost significant negative coefficients for Stage II (p = 0.075) and a significant negative coefficient for Stage IV (p = 9.74e-5) relative to the levels observed in Stage I tumors.

RA females showed a trend toward an increase in sCD14 levels when compared to control females ( P = 0.075).

In the GSE39582 cohort, the difference was only marginally significant ( Figure 5B ; P = 0.076), although the high EPSTI1 group still had a smaller infiltration abundance than the low EPSTI1 group.

Using X-tile method, we found that patients with a Kyn : Trp ratio less than 0.09 showed a trend for better OS (HR = 0.66, 95% CI, 0.40–1.110; p = 0.076; Figure 3 ).

In Vp4 PVTT patients, pre-PSM analysis showed a trend toward improved survival in the HTP group (13.3 vs. 11.4 months; HR=0.64; 95% CI: 0.39-1.05; P =0.076), which became statistically significant post-PSM (15.3 vs. 9.3 months; HR=0.51; 95% CI: 0.26-0.98; P =0.040).

Of note, a clear trend was observed with decreased PD1 + CD4 + Tregs at day 8 post ablation in TDLN in both slow and fast freeze groups ( P =0.076 and P =0.082, respectively Supplementary Table 2 ).

Regarding tumor characteristics, the distribution of CNCL stage showed a trend toward differences (p = 0.076); stage IIa disease was observed in 25.0% of the non-recurrence group compared to 50.0% in the recurrence group, while the distribution of other stages was similar.

All experiments showed a trend towards a reduced expression of Ki-67 in Tat 101 cells, compared to Tet off (p=0.0769) ( Figure 1E ).

Among them, the causal effect of OSA on IL-5 was almost significant [estimate: 0.267 (−0.030, 0.564), p = 0.078].

The multivariate analysis identified a significant correlation between the age group of ≥ 40 years and a high ( P =0.018; Figure 2 ), as well as a marginally significant association between the presence of transcription-related gene mutations and an improved ORR ( P =0.078; Figure 2 ).

In terms of fatigue severity, a significant positive correlation was found between serum Galectin-9 levels and the fatigue severity (r=0.24, p=0.039) ( Figure 5B ), a trend toward significance was found for CD163 levels (r=0.21, p=0.078), but not for the other measured inflammatory mediators.

A marginally significant difference in the neoantigen scores between the responders and PD groups was observed (p-value = 0.078).

Post-menopausal WLWH showed a trend toward higher IL-1β production compared to both pre-menopausal (p=0.078) and peri-menopausal WLWH (p=0.078).

Markers for goblet and enteroendocrine cells were not significantly affected by IFNg treatment, though we observed a reduction in lysozyme, a Paneth cell marker, at near statistical significance ( p = 0.0781).

Besides, CD8+CAR+ cells from patients receiving Axi-cel showed a trend towards a reduced proportion of a central memory phenotype as compared to patients infused with Tisa-cel (p=0.0789) ( Supplementary Figure 6B ).

Compared to Wistar rats, WKY rats exhibited lower levels of 5-HT in the hippocampus (marginally significant, p= 0.0789) and colon, reduced mRNA expression of TPH1 and IDO1 in the colon, while increased mRNA expression of TPH1 in the ileum.

Interestingly, when toripalimab was administrated two days after chemotherapy rather than being used simultaneously, the combinational neoadjuvant regime showed a trend toward a higher pCR rate (36.4%, 4/11 versus 7.7%, 1/13, P = 0.079) ( 60 ).