Excerpts

Joint analysis of phases I and II confirmed our findings, with a highly significant association of rs3774275 with pulmonary tuberculosis (joint analysis OR = 0.61 95%CI = 0.43–086, p = 0.0028; see Table 2 ).

As shown in Supplementary Figure 2 , high scores for cluster_2 and cluster_3 were significantly associated with poorer survival outcomes (p < 0.001 and p = 0.005, respectively), while cluster_0 also demonstrated an unfavorable trend (p = 0.0031), highlighting their potential prognostic relevance. 3.4 Reconstruction of malignant epithelial cell differentiation trajectory To further investigate the transcriptional heterogeneity and differentiation dynamics of malignant epithelial cells, a pseudotime trajectory analysis was conducted.

A direct comparison between SCIgA/M and IgA/M demonstrated a clear trend toward a better protective effect of the former ( p = 0.0040 for Peyer's patches, p = 0.0625 for mesenteric lymph nodes, p = 0.0625 for the spleen, p = 0.8633 for the liver, p = 0.0019 for weight loss and p = 0.1110 for disease scores).

They assessed that following fMLP activation, the reduction in the number of gated cells with a CD123/HLA-DR protocol was highly significant ( p < 0.004) compared with anti-IgE ( p < 0.99), which was exactly the opposite opinion of others, reporting a CD123 quite unchanged upon fMLP activation ( 1 , 4 ).

Compared to the 1.041 HR value in the adult cohort, the 1.092 HR value for the influence of PIRCHE-II score was also more than twice as high in the pediatric cohort; however, most probably due to the low number of cases, the result did not reach statistical significance ( P = 0.004 and 0.18, respectively).

In line with this suggestive association result, the comparison of medieval cases with modern individuals yielded a frequency difference that was highly significant (10.2%; p = 0.005 , OR = 3.61) ( Table S1 ).

Conversely, HT pregnant women treated for 30 days with ferrous sulfate (Arm D) showed a trend ( p > 0.005), yet not significant, toward an increase of RBCs (from 3,650 ± 163 × 10 3 to 3,960 ± 230 × 10 3 ) and Hb (from 10.8 ± 0.8 to 11.3 ± 1.1 g/dl).

Of note, we observed a significant trend toward normalization of the B-cell compartment with significant increases in (i) the percentages of CD19 + CD27 + memory B-cells ( p = 0.005) and of non-class-switched memory B-cells ( p = 0.030) and (ii) class-switched memory B-cells (absolute count and percentage, p < 0.0001) in resolved cGVHD.

Highly significant ( p < 0.005) associations occurred between antibody responses and MHC-I_10, and a significant association ( p < 0.05) was identified for MHC-I_02 and MHC-I_08 (Table 5 ).

Here, we demonstrate that a single subcutaneous injection of Syrian hamsters with 200 μg active papain, 1 h before percutaneous exposure to 150 cercariae of Schistosoma haematobium , led to highly significant ( P < 0.005) reduction of >50% in worm burden and worm egg counts in intestine.

The correlation between the assays in prepandemic samples was also highly significant ( p = 0.005) whereas it did not reach statistical significance in the pandemic samples.

Correlation between XCL1 expression and the presence of CD8+ DCs was also highly significant (p = 0.0055, R2 = 0.443) ( Figure 3E ).

IDO-1 positivity in immune cells was found to be significantly associated with OS in the univariate setting and was borderline significant in the multivariable model [P-value = 0.006 and 0.053; HR: 0.798 (95% CI: 0.635-1.003)].

CERAD Delayed Recall maintained borderline significance across models (Model 1: +0.45, P = 0.006; Model 2: +0.41, P = 0.017; Model 3: +0.37, P = 0.035).

In MS patients, none of these correlations survived the FDR correction, but butyrate and valerate concentrations showed nominally significant positive correlations with TNF (rho=0.374, p=0.006 and rho=0.370, p=0.006, respectively).

The differences, in terms of cytokine amount, observed between swab positive and negative subjects in our cohort are highly significant (at least p=0.007) for certain immune factors (IFN-α, IL-1ra, IP-10, IL-9 and MIP-1β).

Comparing the groups, we observe significant or marginally significant differences for the AP metabolites: C3 ( p = 0.007), properdin ( p = 0.016), FB ( p = 0.084), C5 ( p = 0.057), and FH ( p < 0.001).

We observed an increasing trend in the expression of miR-146b-5p over time, with levels in the D4-7 group significantly higher than those in the D1-3 group ( p = 0.0073), the expression in the D13-21 group was greater than that in the D4-7 group ( p = 0.0200).

TKM-011-treated mice also showed a trend toward decreased CD5 + CD19 + B cells in the liver and spleen (0.8471 ± 0.5212 vs. 1.853 ± 0.8007 × 10 4 /g liver, p = 0.0074; 1.204 ± 0.6144 vs. 2.102 ± 0.8967 × 10 7 /g spleen, p = 0.0431), although this did not achieve statistical significance for CD5 − CD19 + B cells (1.509 ± 0.9114 vs. 3.286 ± 2.396 × 10 5 /g liver, p = 0.0553: 1.354 ± 1.001 vs. 2.057 ± 1.188 × 10 8 /g spleen, p = 0.0878).

By using next generation sequencing (NGS), the decreased SHM frequency was also highly significant ( Figure 2C , 12.3‰ vs 8.3‰, p=0.008, individual mice in Supplementary Table S2A ).

However, a similar association with changes in CSF anti-IgLON5 IgG4 was highly significant ( p = 0.008, Figure 4C , right panel), confirming CSF anti-IgLON5 IgG as the major influence on zQ IgLON5-IgG4 .

Between REST and POST40, Completers showed a decreasing trend while Non-completers exhibited an increasing one (-0.46 ± 0.86 vs. 0.93 ± 0.97 pg/ml; p=0.008) and this difference was also present between POST10 and POST40 phases (-0.26 ± 0.76 vs 0.72 ± 0.75 pg/ml; p=0.024).

However, when groups were matched for both CCR5 promoter haplotype and age (n=6 for both) reduced CCR5 density on monocytes in controllers relative to HCs was highly significant ( P =0.009).

Pathological visual evoked potentials showed a highly significant association to the occurrence of OCB in tears ( P = 0.0094).

However, highly significant elevated CM AAb titers were found in our cohort of non-recovered patients (n=6) ( Figure 1B , p=0.0096) compared to normal healthy subjects.