Excerpts

In contrast, group 3 showed a trend toward higher levels of expression in radiosensitive lines. 3.3.

To further explore this susceptibility, we recently conducted genome-wide association studies (GWASs) which identified six highly significant susceptibility loci [ 11 , 12 ].

Maintenance regimen demonstrated in univariate analyses borderline significance, and in multivariate analysis maintenance therapy was an independent prognostic factor for infants with MRT.

However, even if our results about efficacy are significant, we acknowledge that our study displays limitations, including the small number of patients in the compared groups with 12 patients in the “matched therapy group”, and 25 in the “non-matched therapy group”, and the imbalance of characteristics between these groups with a strong trend for more patients with PC in the first one (83%) than in the second one (44%).

Although not statistically significant, our data show a positive trend with the use of the different therapeutic regimens in terms of CR increase (64.5% with GnRHa + LNG-IUD versus 80.0% with MA+LNG-IUD and 83.3% with MA + LNG-IUD + MET), and a negative trend in terms of SD evidence (25.8% with GnRHa + LNG-IUD versus 15.0% with MA + LNG-IUD and 8.3% with MA + LNG-IUD + MET).

Even if not significant ( p = 0.65), an increasing trend of CR and a diminishing trend of SD were observed according to hormonal therapy ( Table 2 ).

Budding and the presence of cell nests is at the limit of significance. 4.

Nevertheless, concerning budding, the authors had found a borderline significance suggesting that external validation might be needed for budding as a prognostic factor of LUSC [ 17 ].

The performance status showed a trend for a correlation to 5-year survival rate at 25% for PS3-4, 65% for PS1-2 and 68.3% for PS0. 3.4.

This difference was nearly statistically significant.

Thus, there was a clear trend of dependency ( Table 1 ).

Origins of Additional Power of LPM A t -test result may be significant for two reasons: (1) there is a consistent change in most or all tumors away from control behaviour; or (2) there are very large changes in a few tumors, large enough to compensate for a lack of change in others.

Although not statistically significant, our cohort observed a clear trend towards a higher mutational load in male patients, which goes in line with previously published data [ 28 ].

Nevertheless, RG2 cells showed a trend of forming more colonies than RG0 and RG1 despite no statistical significance given ( Figure 3 B-b).

The bias assessment of the studies that investigated mixed interventions showed a trend towards high risk for bias (one trial with “low”, two trials with “some concerns” and three trials with high risk of bias).

One study including 108 multiple myeloma patients that underwent autologous stem cell transplantation showed a trend towards progression-free survival in patients with immunoglobulin recovery compared to patients with immunoparesis.

Subsequent cfDNA samples were all positive with an increasing trend, and the patient progressed with bone metastasis nine months after surgery.

Interestingly, BHPrS1 EFNB3 CM showed a trend of increased LNCaP cells proliferation compared to controls.

Overall, there was a decreasing trend in the incidence and mortality rates of ovarian cancer globally.

All SIMs separated the survival curves considerably, except pre-treatment PLR which showed marginal significance for OS.

Among these, the retrospective analysis of the phase 3 study KEYNOTE042 indicated a clear trend towards better OS in the KRAS MUT group when comparing first-line ICB versus platinum-containing chemotherapy (28 vs. 11 months) than for the patients with KRAS WT (15 vs. 12 months) [ 45 ], albeit only 301 out of 782 patients were molecularly assessed for KRAS status, among which 69 KRAS MUT cases were identified.

The highly significant p -values indicate that γ-H2AX is a reliable choice of marker for the evaluation of aneuploidy-induced replication stress.

Cardiovascular comorbidity and other neoplasms showed a trend toward worse survival, but the difference was not statistically significant ( p = 0.186 and p = 0.052, respectively). 3.3.

Although Kras G12D lungs showed a trend toward increased number of lymphoid aggregates compared with WT lungs ( Figure S2 ), Tslp tg Kras G12D lungs contained a significantly higher number of T cell-rich lymphoid aggregates compared with Kras G12D lungs ( Figure 3 a).

Bile acids ( Figure 2 k) showed an interesting increase at the TKO premalignant stages (20–36 %lifetime), a decreasing trend in the early disease stages (36–80 %lifetime), followed by an increase in the advanced stages. 3.3.