Excerpts

Christensen and colleagues [ 75 ] showed that increasing alcohol intake had a strong trend toward decreased DNA methylation.

The OS data remain immature but also showed a trend towards improvement in the overall population and AKT pathway mutated population.

Lung and lymph node metastases did not reach statistical significance in rPFS analysis even though a negative trend is represented in survival curves.

Most importantly, we show that an increase in cell numbers after the end of endocrine treatment is of highly significant clinical relevance but that a (re-)uptake of therapy can lead to re-decreasing CETC and to potentially minimize the risk of developing metastases.

A previous pilot study showed a trend towards a higher exposure to buccally delivered fentanyl in patients with mucositis compared to patients without mucositis [ 21 ], while another study showed no differences [ 22 ].

Both trials showed a trend toward higher response rates in the CPX-351 groups compared to control groups, but no differences in term of survival.

The inhibition of CREB by 666-15 proves to be more effective than ERK and MEK inhibition, indicated by a significant sensitizing effect for MX in β1-integrin deficient cells, which is even highly significant in combination with COL1.

OS and PFS were shown to correlate significantly with nodal stage and a positive trend for OS with CTV ≤ 400 ccm). 4.

Therefore, also in brain metastatic NSCLC patients, the detected EpCAM-positive CTCs could indicate CSCs properties, and would thus explain the highly significant association of even one CTC/7.5 ml with a poor patient outcome.

High waist circumference (HR: 1.12, 95% CI: 1.04, 1.20), elevated cholesterol (HR: 1.07, 95% CI: 1.01, 1.13), and high blood pressure (HR: 1.11, 95% CI: 1.05, 1.17) were each significantly associated with higher risk of breast cancer among postmenopausal women, and there was a clear trend in increased risk with increased number of MetS components among postmenopausal women.

The highly significant studies, uncovering the tight association between gut microbiota and tumorigenesis, as well as gut microbiota and anti-cancer therapy, are here described.

Likewise, macrovascular network would be a MRI biomarker signature that may identify distinct GBM phenotypes associated with highly significant survival differences and specific molecular pathways.

A decrease in the amount of mutant KRAS ctDNA during or after the first cycle of chemotherapy showed a trend towards a better disease control rate (CR+PR+SD) as shown on the first radiologic evaluation scan.

Moreover, in the range of the physiological membrane potential (i.e., at 0 mV clamp voltage, see below), TTFields increased (T98G cells) or showed a trend to increase (U251) the membrane conductance of the clamped membrane area ( Figure 3 D) suggesting that TTFields may interfere with the physiological electrosignaling of glioblastoma cells.

Notably, MC histology and the absence of RT in the initial treatment, which had been identified as risk factors for VLRs [ 18 ], were of marginal significance, with hazard ratios in the order of 3 in the prediction of EXLRs.

Consistent with this, mass spectrometry showed a trend toward increased NRF1 protein abundance following NanA (log 2 FC = +1.55; padj = 0.135; Table S7 ).

Even including the results of this trial in the overall analysis, there was still a highly significant better response for radiation and heat compared to radiation alone.

Both proteins showed a trend toward decreased expression with advancing NSCLC stages ( Figure 7 E,F).

However, a trend toward significance was observed when considering the entire patient cohort, and the lack of statistical significance might be due to the limited number of patients studied.

Conclusions Complex airway surgery including carinal resections, with or without lung resections, is still burdened with high perioperative mortality and morbidity, although there is a decreasing trend in recent studies thanks to improvements in the fields of surgery, anesthesiology, and intensive care.

However, a possible trend was seen towards a better response in patients with an increasing paclitaxel exposure, although the number of patients with a clinical complete response was only two.

Moreover, a statistical trend was observed for detrimental outcome when patients with RET fusion-driven solid tumors were treated with ICI compared to other regimens.

An overall trend of higher percentage of patients with copy number gain, compared with copy number loss (annotated as “gain%” and “loss%”, respectively, in Supplementary Tables S2 and S3 ) was observed.

However, patients who demonstrated an increase in ctDNA levels between baseline and surgery showed a trend toward lower 5-year disease-free survival (HR 3.66).

The combination of two fractions of IR with anti-CTLA4 yielded a favorable trend in tumor growth delay compared to two-fraction IR with IgG, although it was not statistically significant (median days to endpoint: 13.5 Gy × 2 + anti-CTLA4 44 days, 13.5 Gy × 2 + IgG 41.5 days; Figure 4 d).