Excerpts

Furthermore, in the study of 24 CC patients, ctDNA variant allele frequency values at baseline showed a trend for a shorter PFS but this correlation was significant when focusing on the IHCC group [ 92 ].

This large-scale nationwide population-based cohort study revealed an increasing trend of the risk of all hematologic malignancies and NHL according to the progression of the glycemic status toward diabetes with a longer disease duration, without a significant interaction with obesity.

In EAC, a strong trend of earlier recurrence could be observed in the high S-DKK1 group with a median of 13 months (95% CI 6.96–19.04 ± S.E. 3.08) compared to patients with low S-DKK1 with a median of 17 months (95% CI 9.95–24.05 ± S.E. 3.60) ( p = 0.064) ( Figure 3 A).

The microcalcifications content for healthy MRT-treated samples show an increasing trend with the peak dose ( Figure 7 a), but no visible trend for their crystalline domain values or XRF Fe intensity signal is retrievable.

Visual disorder scores showed a trend to improve over time, although this was not significant.

Although its mortality rate is on a decreasing trend, prognostication and treatment selection is complicated, largely due to its high genetic and morphological heterogeneity [ 2 ].

76.8%) and reported a strong trend towards longer OS (HR 0.72; 95% CI 0.51–1.02).

Similarly, xCell showed significantly higher levels of CD8+ T cells in patients with pCR than in those with non-pCR; this difference was marginally significant according to CIBERSORT.

Interestingly, a strong association between G allele presence at MOR A118G and increased breast cancer incidence in females has been reported and is interpreted as a highly significant risk factor in breast cancer development [ 18 ].

We observed that the bioluminescent intensity of the tumor in the control group generally showed an increasing trend similar to that of the tumor volume ( Figure 6 A,C,D).

At 11 months post-DEN injection, LmiR21KO tend to have a higher liver weight than their control littermates (miR21fx—CTRL), while miR21KO mice display highly significant hepatomegaly ( Figure 2 A).

Despite a high variability between mice, inherent to these analytical methods, a positive trend for ERK1, p38, and JNK over-activation was observed in DEN-treated LmiR21KO or miR21KO mice as compared to CTRL mice ( Figure 4 C).

Similarly, β-catenin protein expression was also decreased in tumors of mice treated with the combination therapy ( Figure 4 I,J); however, this difference did not quite reach significance. β-catenin is involved in cell–cell adhesion through interaction with the E-cadherin cell-adhesion complex [ 44 ], and gastrin has been shown to increase metastases by inducing β-catenin nuclear translocation [ 45 ].

There was a clear trend between larger motion amplitudes and greater distances from the spine for lung, kidney, adrenal gland, and lymph node lesions, but not for hepatic lesions.

Among the highly significant differentially methylated position (DMP)-associated genes, we identified that the miR-33b gene is hypermethylated and may be involved in the dissemination of ovarian cancer cells in the omentum ( Figure 1 A).

32 months, p = 0.10); nevertheless, there was a favorable trend in the conventional group for patients with bilobar neoplasia, portal hypertension, and elevated AFP [ 70 ].

No significant differences were found between the two PET radiopharmaceuticals on a per-patient-based analysis; conversely, a trend towards significance in favor of 18 F-FDOPA PET/CT was identified on a per-lesion-based analysis [ 28 ].

In contrast, Laurén’s classification, which is widely adopted, has not shown prognostic significance, even though a trend towards significance was seen.

* p -value < 0.05 was considered as a statistically significant and **** p -value < 0.0001 was considered as extremely significant.

Both LDN and LD-NDN showed a trend for a reduced expression of CD73 compared to NDN ( Figure 5 B).

An unplanned subgroup analysis showed a trend for enhanced EFS for patients aged 60 years or younger who received rituximab.

A p -value of ≤0.10 was considered as borderline significant, and ≤0.05 as statistically significant. 3.

The intake of dietary calcium showed a trend similar to that reported in previous meta-analyses; however, these studies focused on BC incidence [ 107 , 108 ].

The results of our study confirm that the changes in the glycosylation level of fibrinogen were highly significant, with haptoglobin, serotransferrin, and, to some degree, hemopexin, also useful in the differentiation of LC patients from control subjects.

There was a similar but borderline significant trend for BAFF ( P trend = 0.08; Table S4 ).