Excerpts

Elderly HNSCC patients with reduced kidney function who were treated with radiotherapy alone showed a trend towards lower OS, although statistical significance was not reached ( p = 0.112).

Moreover, three of them showed a trend of upregulation during disease progression from healthy controls to primary and metastatic melanoma cases. 2.

Increasing levels of haemoglobin and CRP were significantly associated with lower disease control rates during chemotherapy, whereas haemostatic biomarkers (D-dimer, F1+2) predicted for a lower probability of disease control with borderline significance.

As it was shown in Figure 1 C, the lower staining intensity of COX5B in tumorous, when compared to nontumorous part, were associated with a better prognosis in OS, recurrence-free survival (RFS) and metastasis-free survival (MFS), albeit a borderline significance in OS.

Because this difference is highly significant, it is possible that downregulation of NRBP2 may reflect an immature, progenitor-like state of MB cells, and that loss, or reduction, of NRBP2 expression during tumor formation relates to an undifferentiated state by which MB aggressiveness increases.

LPCs showed a trend towards reduced levels in samples from CCA, which reached statistical significance in those from PDAC patients.

In Korean women, the current mean age at menopause is lower than that in other countries such as the United Kingdom, Australia, or Japan but shows an increasing trend [ 17 ], which may possibly contribute to the increased breast cancer-related burden.

Subtype was significantly associated with the presence of distant metastasis at diagnosis and showed a trend towards significant association with lymphovascular invasion (LVI) at diagnosis, with a higher proportion of cases with LVI and distant metastasis for subtype A compared with B.

The presence of distant metastasis at diagnosis and recurrence after surgery are significantly more common for subtype A PNENs, and a trend towards significance was observed for LVI at diagnosis.

Even after adjusting for the cancer stage, the positivity of the D-marker panel and cancer progression remained associated with marginal significance, and the adjusted HR (95% CI) was 1.29 (0.92 to 1.80) (Model 2).

Values of p < 0.05 and p < 0.01 were considered significant and highly significant (Excel, Microsoft, Seattle, WA, USA). 5.

There was a significant trend for TP53 and RB1 mutations to occur together, while both TP53 and RB1 were mutually exclusive with respect to CDKN2A/B inactivation.

Interestingly, both melanoma cell lines showed a trend to higher metabolic activity in ADA–GEL and HA-SH than mammary carcinoma cells during long-term cultivation (>7 days).

MCF-7 showed an overall trend for the highest apoptotic and necrotic rates.

A large, prospective, population based-study demonstrated a highly significant association between carriage of Porphyromonas gingivalis ( P. gingivalis ), and the risk of pancreatic cancer development [ 4 ].

In normoxia, MCF7-miR526b and MCF7-miR655 cell lines show an extremely significant upregulation of HIF-1α gene expression compared to MCF7 ( Figure 1 B) and SKBR3-miR526b cells showed an extremely significant increase in HIF-1α gene expression compared to SKBR3 ( Figure 1 C). 2.1.2.

On the other hand, there is a strong trend to discriminate malignant cells from the healthy ones by adjusting the threshold for CAR-T cell activation.

For TNBC, CD20-low, CD8-high identified a statistically significant poor prognostic group, with double-low status not quite significant.

Objective and significant risk factors for radiation dermatitis were the breast volume and the applied irradiation technique; a boost radiotherapy administration also showed a trend towards a slightly more severe radiation dermatitis.

Indeed, we observed in our cohort that mutations in PTEN and EGFR are enriched in the PD group (24.5% and 13.3%) compared to the SD+PR group (10% and 0%), although only the difference for EGFR is borderline significant.

CTLA4 (p = 0.077) and LAG3 (p = 0.066) showed a borderline significance. 3.3.

A resection margin of <1 mm showed a trend but not significantly better LRFS or OS compared to a contaminated margin.

Even if not significant, mutations in CDH8 and XRCC6 showed a positive trend of association with the biph-MPM subset.

Relapse or persistent disease after two years showed a trend toward improvement at 15.6% for NAC vs. 19.5% for adjuvant chemotherapy, but did not meet statistical significance (HR = 0.76, 95% confidence interval (CI 0.56–1.02; p = 0.07).

154 of these 155 proteins were also measured in the replication cohort and among these 154 proteins, 92.2% (142/154) were nominally significant also in the replication cohort ( Table 1 ) and 85.1% (131/154) remained significant after multiple hypothesis correction ( Table S2 ).