Excerpts

While no statistically significant differences were identified between arms, p -values for time-by-arm interactions approached significance (e.g., p = 0.051). 3.7.

Only N0 was shown as an independent factor ( p = 0.049), and R0 almost reached statistical significance ( p = 0.051) in multivariate analysis of ENT1 protein expression, analyzed by immunohistochemistry and covariates ( Table 5 ).

No prognostic factors were significantly associated with early or late PCS complications, with thrombosis approaching significance ( p = 0.051).

In the RAISE trial evaluating ramucirumab added to second-line FOLFIRI following progression to bevacizumab plus an oxaliplatin based treatment, the addition of the anti-VEGFR2 agent significantly prolonged survival in the overall population, with a positive trend among the elderly (≥65 years, HR for PFS 0.82, p = 0.051; HR for OS 0.85, p = 0.16).

A similar magnitude difference was observed between XYF and XYM animals (Difference = 98.8 ± 35.5), although this comparison narrowly missed statistical significance after Tukey adjustment ( p = 0.051).

At the 10-year follow-up, a borderline significant 50% reduction in melanoma incidence was observed among daily sunscreen users (HR 0.50; 95% CI, 0.24–1.02; p = 0.051), with a 73% reduction in invasive melanomas across all body sites (HR 0.27; 95% CI, 0.08–0.97; p = 0.045) and a lower mean Breslow thickness compared with discretionary users (0.53 vs. 1.2 mm) [ 10 ].

When stratified by cell-of-origin, the association between rs822336 and RFS was borderline significant in ABC-DLBCL (Kaplan–Meier, p = 0.051), whereas no association was observed in the GCB subtype ( p = 0.300).

When we included all parameters in the model, only Th density was borderline significant ( p = 0.051), but the model could correctly predict the responses in 83.9% of the patients (75% was the baseline). 3.4.

Consistently, the recessive model approached but did not reach significance (OR = 1.606, p = 0.051).

The increase in the mOS difference between patients with high levels of TGFB1 and MGMT methylation compared to those with low levels of TGFB1 and MGMT methylation was borderline significant (14.5 versus 36.9 months, respectively; Adj. p = 0.051) ( Figure 1 B).

The VEGFR2 rs2071559 C variant was a borderline significant risk factor for poor local recurrence-free survival (LRFS) (uncorrected p = 0.051).

The patients with TGFB1 and MGMT methylation showed an increasing trend of mOS related to increasing methylation levels ( p = 0.051): the mOS for TGFB1 lowMe / MGMT lowMe group of patients was 14.5 months; the mOS for TGFB1 lowMe / MGMT highMe group of patients was 17.9 months; the mOS for TGFB1 highMe / MGMT lowMe group of patients was 18.6 months; and the mOS for TGFB1 highMe / MGMT highMe group of patients was 36.9 months.

MMR deficiency was associated with postmenopausal status, tumor grades 2–3, FIGO stages I–II ( p = 0.010, 0.011, 0.006), BMI < 25, and parous state (parity ≥ 1) with borderline significance ( p = 0.051, 0.064).

While results for 2-year progression-free survival show a strong trend toward favoring rituximab treatment, they were not statistically significant, but only by a slight margin (HR 0.52, 95% CI 0.32–0.86, p = 0.051).

However, when demographic factors and NSCLC stage were adjusted for in a Cox proportional-hazards model, abnormal galectin-1 levels were not significantly associated with decreased OS, yet with borderline significance ( p = 0.0513), which is possibly due to our relatively small sample size.

Instead, the increased expression of miR-146a-5p in ulcerated melanomas was borderline significant ( p = 0.0513) ( Figure 4 ).

Finally, a Cox proportional hazards model that included the demographic factors in Table 1 and lung cancer stage showed that abnormal galectin-1 levels were not significantly correlated with OS, with a hazard ratio of 2.928 (95% CI of 0.9940 to 8.625), yet it was borderline significant with p = 0.0513.

The same participants saw relationships trending towards significance for dietary zinc intake for Pt-S and platinum resistance (Pt-R) ( p = 0.0514 and 0.0731, respectively) and dietary B12 intake and Pt-R ( p = 0.0514).

4.0%), approaching significance ( p = 0.0519).

Malignant nodules, regardless of TERT status, showed a trend toward higher RAS AF than benign nodules (23.0% vs. 16.3%; p = 0.052).

The k PL showed borderline significance in predicting the variance in tumor MCT1 expression at the biopsy level ( p = 0.052; Supplementary Figure S8 ) and was independent of the cell density in tumor biopsies ( p = 0.95, Supplementary Figure S7 ).

The univariate analysis also reveals a trend for FC to reduce the increase in financial difficulty, which is marginally significant (β = −0.18 ± 0.094, p = 0.052) ( Table 3 ).

In the multivariate model, the presence of SARIFA showed a trend toward significance in its association with lymph node involvement (OR = 4.886; 95% CI: 0.985–24.241; p = 0.052).

However, as shown in Supplementary Figure S3B , a possible trend toward significance showing an association between SETDB1 expression and NSCLC patients carrying mutations for the TP53 gene was observed (SMD: 0.15; 95% CI: −0.004–0.31; p = 0.052), with low heterogeneity ( I 2 = 0%; p = 0.60).

In survival analyses we observed that high basal levels of IL-6 (over 6.0 pg/mL) were significantly associated with lower OS ( p = 0.029) and were almost significantly associated with lower PFS ( p = 0.052) ( Figure 5 C,D).