Excerpts

A borderline significant difference was found in blast percentage ( p = 0.05), with more patients in the WT1 high group having blast counts ≥80%.

For example, some of the variants and genes from previous NPC studies were present in our cohorts but failed to reach statistical significance ( p < 0.05), perhaps due to an insufficient sample size.

Our analysis reported also a significant trend towards ORR for anti-VEGF combinations (RR 1.46, 95% CI 1.00–2.12; p = 0.05).

We performed a test for ES to evaluate whether the number of studies reporting nominally significant results ( p < 0.05) was greater compared to the expected number of studies reporting statistically significant results [ 29 ].

In the multivariate analysis of this group of patients, only VEGF-C overexpression showed an independent impact on worse prognosis, with a borderline significance value ( p = 0.05, CI 95%: −0.03–3.99, HR: 7.2). 4.

Thus, BCRP coverage decreases in the kidneys (from 67 to 58%, p < 0.05), but increases in the liver (from 33 to 49%, p < 0.001), and in the small intestine (from 42 to 51%, on the borderline of significance) and large intestine (from 39 to 52%, p < 0.05).

showed a potential reduction in the mortality rate in the CGA-driven intervention group, but the study failed to reach significance ( p = 0.05) [ 25 ].

Only lymph node status had a marginally significant effect on DFS (total number of cases: 1528; Z = 1.94; p = 0.05): positive lymph node status significantly worsened the prognosis (HR > 1) by reducing DFS.

In contrast, a study conducted on breast cancer reported a marginally significant reduction ( p = 0.05) in FTO gene expression in the breast tissue of patients with the AA homozygous genotype [ 54 ].

Treatment protocols revealed a borderline significant difference ( p = 0.05).

In addition, a comparison of patients with high-grade and low-grade gliomas via LASSO ( Table S10 ) and ANOVA ( Table S12 ) identified 2-aminoadipic acid (2-AAD) ( p < 0.05; [HGG/LGG] ratio 15.89) as a highly significant metabolite differentiating the two groups ( p < 0.05; [HGG/LGG] ratio 11.33).

The only difference between age groups was a slightly significant increase of grade ≥3 AE (28% vs. 39%, p < 0.05) for the oldest group (mainly skin reactions, treatment secondary malignancies and renal and urinary disorders).

In the final month, the difference in chemotherapy use is borderline significant (8.5% in males and 6.6% in females; p = 0.05). 3.4.

Model 4 constrains the MZ pair correlation to be twice the correlation for DZ and sister pairs combined, and the comparison of the log-likelihoods with those of Model 2 shows that, except for Cirrocumulus , there was at least nominally significant evidence that the MZ correlations were more than twice the corresponding correlations for DZ and sister pairs combined (all p ≤ 0.05).

A total of 1587 SNPs showed a nominally significant association with ESCC ( p < 0.05 and 95% CI did not include OR = 1).

However, we did identify a near-significant ( p = 0.050) association between the presence of a solid growth pattern and low-risk tumors.

Our findings showed a statistical trend toward higher levels of serum calprotectin in patients with inflammatory activity ( p < 0.05).

There was a trend of greater weight loss in patients in both cohorts after surgery, and the statistics were close to significance ( p = 0.050) ( Table 3 IC; Figure 2 II).

Repeating the analyses on metabolic factors and IGF-I after further controlling for weight change, the results continued to show significant reductions in triglycerides ( p = 0.02) and IGF-I ( p = 0.03), while the reduction in total cholesterol became borderline significant ( p = 0.05).

When histotype was stratified by tumour stage, Kaplan–Meier analysis revealed a borderline significant difference in survival between patients with homologous and heterologous histotypes (log-rank p = 0.050).

The remaining analyzed risk parameters—T and N pathological stage, and LVI and PNI status—did not show a statistically significant association with overall survival time by univariate analysis ( p > 0.05), while received adjuvant therapy almost reached statistical significance ( p = 0.05).

Additionally, a highly significant Spearman’s correlation was found between the reciprocal expression of SST mRNA and SST1 mRNA in the control group (R = 0.69, p < 0.05) ( Table 4 ). 3.3.

Experiencing TRAEs of grade 3 or higher showed a trend towards worsening OS (HR 1.79, 95% CI 1.00–3.21, p = 0.05) and PFS (HR 1.53, 95% CI 0.90–2.59, p = 0.12).

According to other studies [ 36 , 37 ], our patients whose tumor occurred with obstruction or perforation showed a worse DFS compared with the other tumor manifestations, although with a trend towards significance (HR = 2.65, 95% CI 1.00–7.01, p = 0.050).

Second, there are genes (seen in green) that show a moderately significant change in expression ( p -value < 0.05) and an absolute value of log 2 FoldChange > 2.