Excerpts

Although dozens of clinical trials have been performed, the results of most have been inconclusive or of borderline significance.

We showed a highly significant shortening in average telomere length in T/NT nuclei compared with diploid nuclei.

This is an important determinant, because the effects of the immune system on bone metastasis may be significant.

In the toxicity analysis, the HDR-BT group showed a higher GU toxicity ratio than the IG-IGRT group, whereas there was an equivalent (or borderline significance) rate in GI toxicity.

Most importantly, we show that an increase in cell numbers after the end of endocrine treatment is of highly significant clinical relevance but that a (re-)uptake of therapy can lead to re-decreasing CETC and to potentially minimize the risk of developing metastases.

A previous pilot study showed a trend towards a higher exposure to buccally delivered fentanyl in patients with mucositis compared to patients without mucositis [ 21 ], while another study showed no differences [ 22 ].

A decrease in the amount of mutant KRAS ctDNA during or after the first cycle of chemotherapy showed a trend towards a better disease control rate (CR+PR+SD) as shown on the first radiologic evaluation scan.

Moreover, in the range of the physiological membrane potential (i.e., at 0 mV clamp voltage, see below), TTFields increased (T98G cells) or showed a trend to increase (U251) the membrane conductance of the clamped membrane area ( Figure 3 D) suggesting that TTFields may interfere with the physiological electrosignaling of glioblastoma cells.

This set of experiments showed that the daily treatment of mice with FPP ® administered by both gavage and sublingual induced a highly significant reduction of tumor growth, slowing down the progression and suggesting therapeutic properties of FPP ® .

Even including the results of this trial in the overall analysis, there was still a highly significant better response for radiation and heat compared to radiation alone.

Both proteins showed a trend toward decreased expression with advancing NSCLC stages ( Figure 7 E,F).

The recalcification rate was lower in the single fraction group (120%) compared to patients who received fractionated RT (173%, p < 0.0001) with a slight trend favouring 10 × 3 Gy RT scheme [ 17 ].

Several genes show an extremely significant p value combined with a high fold change and high AUC value.

A pronounced increase of γH2AX foci was observed 0.5, 2, 4 and 8 h after 2 Gy radiation in MK801 treated cells, which was highly significant at 4h ( Figure 3 C).

However, the statistical power may be inadequate to highlight some of the differences that were found not to be statistically significant in the study but that showed a trend toward it.

When comparing the average total levels of H3K14ac (given by the sum of H3K14ac, H3K9me1/K14ac, H3K9me2/K14ac, H3K9me3/K14ac, and H3K9ac/K14ac) in the normal-tumor pairs for all the tumor types tested, we found a highly significant decrease in tumor samples, with a paired t -test p -value of 0.00013 ( Figure 1 E).

However, we also found that BPDCN patients with high levels of PD-L1 protein expression (H-score ≥60) showed a trend toward worse OS and progression to AML compared those with low levels of PD-L1 (H-score < 60), warranting future validation of this finding in a larger patient cohort.

A dose of 1 μM AB3 (mean ± SEM, 2.10 ± 0.02, p = 0.822) also showed a trend toward increased SSTR2 expression, but this increase was not found to be significant.

Discussion Our initial analysis revealed slightly worsened DFS and DSS in BRCA1/BRCA2 mutation carriers compared with non-carriers; however, the difference was less than 10% at 10 years and marginally significant for DSS only (HR = 1.65 95% CI 1.01–2.70).

Overall, survival analyses showed a trend toward better OS for HPV-positive (67% survival) compared to HPV-negative (27% survival) patients but that did not reach statistical significance ( p = 0.12), most probably due to the small number of HPV-positive cases ( Figure 4 A). 2.3. p16Ink4a Protein Immunohistochemical (IHC) Staining In view of the small number of HPV-positive HNSCC patients found in this cohort, and the limited amount of pathological materials available, a subset of 50 representative specimens were processed for p16 protein IHC staining.

The relationship between HPV and OS after the treatment showed a clear trend toward a longer survival of HPV-positive patients ( Figure 4 A) as described elsewhere [ 40 ].

III-IV, p = 0.019), more frequent mutations in the miR-887 gene in males ( p = 0.045), and a borderline significant correlation of miR-664b gene mutations with lower cigarette-per-day-smoking in LUAD.

Second, patients who received a greater number of overall therapies showed a trend toward longer OS, as did those patients who received a greater number of clinically beneficial therapies.

Although non-significant, our results in the intermediate- and high-risk groups showed a small trend towards the possible risk reduction of statin use on the development of BCR after RP.

Nonetheless, the induced cell death in D283 and D341 cells still remained quite significant when compared to their untreated control cells.