Excerpts

The multivariate binomial regression analysis revealed that only log (IL-6) ( p = 0.05, Estimate 3.69) demonstrates a nearly significant association with sarcopenia, but not the other variables used in the model (CP score, PMNs/lymphocytes ratio, BMI) ( Table 4 ).

The pooled HR showed a trend towards better OS only for good-quality studies ( Supplementary Figure S8 ) in the sensitivity analysis, while there was no association between poor- and fair-quality studies.

Two-tailed Bonferroni corrected p < 7.35 × 10 −4 (0.05/68) for UKB and p < 5.32 × 10 −4 (0.05/94) for ChinaPCa were considered statistically significant, while the p -value between Bonferroni correction and 0.05 was deemed marginally significant on SNP association analysis.

In our cohort, patients with metastatic cutaneous melanoma treated with corticosteroids plus second-line immunosuppressants showed a trend towards a longer OS compared to patients treated with corticosteroids only for grade 3/4 irAEs.

However, further survival analysis after the homogenization of both collectives showed that the platinum-treated cohort had a highly significant shorter PFS compared to the untreated group, so the data appear valid despite the small case number.

The grades (in-house collected samples) showed a trend of increased HIF-1α expression in grades 2, 3 and 4 compared to grade 1 ( Figure 3 A).

Indeed, we found a highly significant reduction of green fluorescence in NCCR reporter transduced MKL-1 cells upon PHT treatment, suggesting repression of MCPyV early gene transcription, while late gene transcription showed a slight, but statistically not significant, increase ( Figure 1 e).

Analysis of DCF fluorescence, which detects many types of ROS, showed a trend towards an increase in Gem- and His-only treated cells and a significant increase ( p < 0.05) in cells treated with a combination of both drugs compared to control ( Figure 3 B).

Less closely aligned with observations of most [ 2 , 14 , 19 ], but not all [ 16 ], of the four previously published studies and of the single case report [ 20 ] examining the issue in patients with higher tumor burdens, our findings suggest only a possible trend towards a tumor sink effect of PSMA-targeted radiopharmaceuticals in the liver.

The ADC also showed an increasing trend from the periphery of WHO 2 lesions to infiltrative oedemas around WHO 3 lesions to vasogenic oedemas around metastases, although showing largely overlapping values.

The comparison between histotypes showed that both the intracellular and vascular fractions tended to be higher in tumours with high cellularity (glioblastoma and metastasis), and quantitative analysis showed a trend toward higher values of the intracellular fraction (fic) within the tumour core with increasing glioma grade.

In particular, a clear trend for the diminution of the primary groups was observed when comparing the healthy and low metastatic tumoral exosomes.

Unlike Japan, it did not show a decreasing trend.

The statistical data obtained in the course of the treatment of various oncological malignancies demonstrated an obvious trend: an increased concentration of Fe in the cell increased the risk of cancer formation from 20 to 200 times [ 92 ].

Quantification of the relative fold-change in nuclei confirmed a highly significant reduction in the number of naïve hBMSCs (0.321 ± 0.029) when treated with conditioned media from hBMSC spheroids incubated with doxorubicin ( Figure 4 c).

For male and female kidney cancer, improvement in survival came in two waves, interrupted by a slow improvement around 1990, followed by a positive trend before the year 2000; the increase was highest in 5-year survival, from over 40% in 2000 to almost 80% towards 2020.

A clear trend between fibrosis grade and spleen response rate was observed for patients achieving a spleen response at Week 24 or at any time during the study, with response rates decreasing with increasing fibrosis grade ( Figure 1 B).

In that study, an EpiSwitch systemic biomarker associated with regulation of the POU2F2 locus provided highly significant binary baseline calls for benefit from treatment with Avelumab in combination with best supportive care (BSC) against the control arm of BSC alone, demonstrating a Hazard Ratio of 0.44.

GWAS-Catalog Lookup We performed a lookup of all nominally significant SNPs and genome-wide significant genes identified from GWAS as described in Section 2.3 in the EMBL-EBI GWAS catalog (summary statistics downloaded on 1 October 2022) [ 30 ] to identify the known associations of SNPs and genes from our study with other phenotypes.

The CCK-BR selective antagonist also slightly increased phosphorylation of downstream AKT in mPSC, but this value did not quite reach statistical significance. 3.2.

In univariate models, HLA mismatching ( p = 0.003) and grade II–IV aGVHD ( p = 0.007) were significantly associated to the risk of cGVHD, while the year of transplant and recipient age showed a marginal trend.

The results showed a trend towards a higher ORR in children than in adults, with 86.59% and 76.32%, respectively, a trend towards a higher ORR in the low morphologic relapse population than in the high morphologic recurrence relapse population, with 85.54% and 74.08%, respectively, and a trend towards a lower incidence of CRS and neurotoxicity in allogeneic T-cells than in autologous T-cells, with 72.00% vs. 88.66% and 41.4% vs. 21.47%, respectively; however, none of these results showed a significant difference because their 95% CIs mostly overlapped. 3.5.

Overall, MYC showed a trend of increased frequency of positive expression in recurrent/metastatic FN RMS, and YBX1 was expressed in all primary and metastatic FN and FP RMS tumor tissue samples examined ( Figure 7 B), suggesting that MYC and YBX1 play a role in both primary and recurrent/metastatic RMS tumors.

BED and DFI also showed a trend with the improvement of DPFS, but neither at univariate analysis nor multivariate analysis did it reach a significant correlation.

Concomitant systemic therapy showed a negative trend with PMFS but was not significant at univariate analysis ( p = 0.07); instead, it had a significant correlation at multivariate analysis ( p = 0.024; HR 2.969; 95%CI 1.157–7.624).