Barely Significant
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“showed a trend”

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In the literature

19–21 Although the parameters of sperm concentration, total motility, survival rate, and sperm morphology showed a trend of decreasing temporarily in some clinical studies, 19–21 some of these parameters (such as sperm concentration, total motility, etc) may recover with time going by. 14 There were also some clinical studies indicated that bariatric surgery has no significant impact on semen parameters, but the sexu
Importantly, the only notable change in this RCT-only analysis was observed for minor bleeding events (BARC type 1).Whereas de-escalation was associated with a significantly lower risk of BARC 1 bleeding in the overall analysis (previously RR: 0.52, 95% CI: 0.32–0.86), the RCT-restricted analysis still showed a trend toward reduced minor bleeding with de-escalation but this difference was no longer statistically significant (RR: 0.65, 95% CI: 0.28–1.50, p = 0.311).This attenuation of significance is most likely due to the reduced sample size and statistical power after excluding the observational cohorts, rather than a true reversal of effect.Overall, the RCT-only sensitivity analysis confirms the robustness of our primary findings.
In sex-stratified analyses, among women, perceived stress showed a moderate negative correlation with sleep quality, weak negative correlations with age and total cholesterol, and a very low negative correlation trend toward 8-hydroxy-2′-deoxyguanosine; in addition, perceived stress correlated positively (very low) with platelet count and illicit drug use and showed a trend toward a positive correlation with morbidity count.