Similarly, Ser→Ala substitution at position 120 also showed a trend, albeit not statistically significant, towards decline (Fig. 3L ).
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In the literature
This is crucial because neoadjuvant pembrolizumab plus chemotherapy showed a trend toward greater benefits in the Asian subgroup of the KEYNOTE-522 trial population in terms of EFS and pCR rates [ 12 ].
This work extends a proof-of-concept study using part of the same cohort, where we showed a trend towards an association with RAS mutations 36 .
Other mutations (FaSdhC1‐H144Y, FaSdhD‐H122Y, FaSdhD‐D133N, FaSdhD‐E166K) also showed a trend of enhanced virulence accompanied by reduced sporulation.
It did not improve MMSE scores (SMD -0.21[-0.33, -0.08]), largely driven by one large secondary analysis, but showed a trend towards reduced cognitive deterioration (RR 0.89[0.73,1.09]) and improved mood (SMD -0.16 [-0.40,0.08]).
Although neither of the two U.S.-based studies demonstrated statistical significance, both showed a trend toward longer RFS in patients with CIS at TURB compared with those without.
However, patients with intermediate imaging–clinical discordance (equation 13–15) showed a trend favoring EVT alone, suggesting that a simple profile-based approach may help inform rapid, individualized bridging decisions when only limited information is available.
Although female mice in the metestrus‐diestrous stage showed a trend for increased glycaemic variability compared to proestrus‐estrous, this was not significant for any measures of variability.
There was a chance imbalance in baseline imaging characteristics: patients subsequently treated with ARG-007 showed a trend for larger baseline ischemic cores and more severe ischemic injury (greater net-water-uptake) prior to randomisation.
No factors were significantly associated to inadequate anticoagulation management in univariate and multivariate analyses, although peripheral artery disease (OR 2.02, 95% CI 0.32-21.86, p=0.46) and higher bleeding risk procedures (OR 1.67 per level, 95% CI 0.75-4.28, p=0,21) showed a trend toward increased risk.
Similarly, in this study, IAR showed a trend toward a negative correlation with VRR in RAS-mutated nodules, possibly due to protein denaturation making the ablation zone less absorbable ( 32 ).
Although various cytokines, including IL6, IL1B , and TNF , showed a trend toward upregulation in submerged HNEC, none of these changes were significant (Figure S10 ).
The influence of the K 2 FeO 4 /sludge ratio was relatively weak but still showed a trend of slight improvement with increasing ratio.
Fab′ installation showed a trend toward reduced lung accumulation, possibly due to the decreased cationic charges following Fab′ attachment.
Semiquantitative findings showed a trend for increased low-frequency (delta and theta) and high-frequency (beta and gamma) power, as well as left frontal alpha asymmetry, in depressed patients compared to healthy controls.
Notably, when comparing COPD patients to healthy controls, PILRA expression was significantly downregulated in macrophages, whereas IL1RN showed a trend toward upregulation in dendritic cells, monocytes, and neutrophils.
Consistent with an increased susceptibility to infection, female flies showed a trend toward higher pathogen loads compared to male flies ( Fig. 1d ).
The SOD activity of the bryophytes showed a trend of first increasing and then decreasing with increasing exogenous Cd concentration (Fig. 2 C).
Regarding other clinical strata (such as age, gender, and baseline comorbidities), exploratory Subgroup analysis indicated that elevated ACAG levels showed a trend of being associated with a higher risk of death in most clinical subgroups, with particularly pronounced effects observed in younger patients (≤ 60 years), individuals with higher BMI (≥ 25), males, and patients without specific comorbidities such as AKI, CKD, HF, MI, or COPD.
Notably, mice receiving high-dose SSG showed a trend of body weight loss toward the end of treatment.
Glut2 showed a trend toward increased expression.
TEN was associated with significantly lower risks of infection, multiple organ failure, and mortality, and showed a trend toward reduced need for surgical intervention.
27 Moreover, greater brain BOLD signals has been reported for true memories compared to false ones in the visual occipital regions (BA18 and BA19), as well as in the posterior portion of the hippocampal gyrus (BA36), which also showed a trend-level activation in the present study.
Age was significantly associated with increased experiences of interpersonal conflict, while Hispanic ethnicity showed a trend toward higher levels of interpersonal conflict, indicating a need for further investigation.
Frontline HSCT showed a trend toward better OS and EFS, but differences weren't statistically significant.