Compared with age-matched children without CPP, GnRH therapy showed a trend toward longer PFS, though not statistically significant ( p = 0.10).
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While patients with SpA showed a trend toward better outcomes compared to RA and PsA, our analysis suggests this may be partly mediated by younger age and specific engagement patterns rather than diagnosis alone.
While [ 177 Lu]Lu-FAP-2286 alone was sufficient to significantly inhibit tumor growth, the combination regimen showed a trend toward improved tumor growth control under the experimental conditions evaluated.
Meanwhile, while the numbers of defective HIV DNA (3′ deletions/hypermutations and 5′ deletions) detected with the IPDA showed a trend of a decrease over time in the 2 groups with total HIV DNA decrease, they remained stable or even increased in the 2 groups with an increase in total HIV DNA ( Figure 2 B ).
The WM group showed a more significant decline in LYM 1–2 weeks after admission, reaching its lowest level at day 12, whereas the LYM count of the TJQW + WM group did not decrease, but instead showed a trend of gradual increase and recovery.
With the increase of liquid-solid ratio, the extraction efficiency showed a trend of first increasing and then decreasing, and reached the highest when the liquid–solid ratio was 20 mL/g ( Fig. 2 C).
By comparing the concentration of different metabolites, it was found that among the 12 different metabolites screened, six of the differential metabolites (LysoPE(22:4(7Z,10Z,13Z,16Z)/0:0), LysoPC(0:0/20:4(5Z,8Z,11Z,14Z), LysoPC(20:3(8Z,11Z,14Z)/0:0), 1- O -Hexadecyl- sn -glycero-3-phosphocholine, LysoPC(p-18:0/0:0), SM(d18:1/16:0)) showed an overall tendency to return to normal, with significant callbacks in the QF group ( P < 0.05), HX group and WJ group also showed a trend of correction.
Cytokine and chemokine changes in circulating blood Overall, cytokines and chemokines showed a trend of increase on both days 1 and 4 post-irradiation, especially on day 4 after high-dose irradiation (15 Gy and 20 Gy) at relative low dose rate (10 Gy/s) (Fig. 8 A).
In advanced-stage disease (ARCO IIIB/IV), the combined-treatment group showed a trend toward improved hip survival; however, this comparison was underpowered due to limited sample size (Fig. 5 D).
The standard-intensity group showed a trend toward increased risk, but this did not reach statistical significance (HR = 3.876, 95% CI: 0.846–17.758, P = 0.081).
After a total of 6h, these differences decreased, and the cell lengths showed a trend towards convergence within each cell morphology (Fig. 2 ).
While there was no significant difference in the overall response rate ( p = 0.09), erlotinib showed a trend toward better results (54.1% ORR vs. 34.3% for GC).
Concentric flexion strength increased significantly from the follicular to the luteal phase (+7.4%), and ankle ROM showed a trend toward improvement, with the highest values observed in the luteal phase (+3.8%).
Second-phase duration showed a trend toward reduced SOE with increasing duration, but no statistical significance for both onset [β = −0.0010, p = .099] and steady-state case [β = −0.0010, p = .092].
This association showed a trend for statistical significance when adjusting only for age at screening and the interaction between age and having sleeping problems (HR = 1.11 [95% CI 0.88–1.38]; p = 0.0638).
24 With regard to foetal and obstetric outcomes, our data showed acceptable foetal livebirth proportions for women with tissue valves, while the absolute risk of pregnancy loss in mechanical valve showed a trend of poorer outcomes, although not statistically confirmed.
Clinical outcomes, assessed through self‐reported data and dermatological indices, showed a trend towards reduced OCD prevalence and improved skin condition, though findings from randomised controlled trials were inconsistent.
Although this analysis is exploratory and hypothesis‐generating, the swimmer plot in our study showed a trend toward increased PFS in patients with local recurrence and a lower number of recurrent lesions compared with those with distant recurrence.
Additionally, T cell polarization assays revealed distinct functional outcomes: monocytes from females promoted a higher frequency of Th2 cells, whereas monocytes from males showed a trend toward increased Th17 cell differentiation ( Figure 4G ).
Despite this elevated oxidative metabolism, quantification of mitochondrial ROS using MitoSOX red fluorescence showed a trend toward lower basal mROS levels at 24 hours following MPLA exposure, which rebounded by 3 days-post treatment ( Figure 4D ).
With the increase of oxidation degree, the naringin-loaded hydrogels showed a trend of denser cross-linking and smaller pore size.
A trial of cyclosporine at reperfusion in liver transplant showed a trend to less AST release, though not significant.
Moderate dopamine concentration (30 μM) showed a trend toward increased proliferation and higher cell counts.
In contrast, gain-of-function studies demonstrated that ESRP2 re-expression in mesenchymal cells restored epithelial morphology, impaired 3D spheroid formation, and showed a trend toward reduced proliferation ( 30 ).
Although MFN1 showed a trend toward increased expression with GDF15 treatment, these changes did not reach statistical significance.