Integrated analysis of sex differences in human dendritic cell, monocyte, and natural killer cell subsets.

First, the sample size is modest, and larger cohorts could refine statistical power, particularly for DCs where trends approached but did not reach significance.

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Additionally, T cell polarization assays revealed distinct functional outcomes: monocytes from females promoted a higher frequency of Th2 cells, whereas monocytes from males showed a trend toward increased Th17 cell differentiation ( Figure 4G ).

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