In contrast, potassium calcium-activated channel subfamily M alpha 1 ( KCNMA1 ), another gene associated with EDHF-mediated responses, showed a trend toward increased expression in GDM HUVECs compared to NG, both under basal conditions ( p = 0.1195) and after insulin stimulation ( p = 0.0548) ( Figure 6 F), indicating a possible compensatory upregulation of the EDHF pathway in GDM. 3.
combination therapy) showed a trend toward improved outcomes after combination therapy (HR: 0.21, 95% CI: 0.03–1.50, p=0.12), but that did not reach statistical significance.
In the 3 liver lesions that we isolated, VIM transcripts were significantly up-regulated ( P < 0.05 ), ZEB1 and ZEB2 transcript levels showed a trend to increase ( P < 0.12 and P < 0.25, respectively) (Fig. 3i ).
It also showed a trend toward greater improvement in the GCS scores ( p = 0.12).
However, subjects with combined obesity and UDP showed a trend toward lower exercise efficiency (p=0.12). 3.4.
However, with the 5% and 50% cutoff values, the T-PD-L1 (+) group showed a trend of disadvantage in survival over the T-PD-L1 (−) group (p=0.12 and p=0.11).
Results showed a trend of higher STMN1 expression in poor responders compared to good responders ( p = 0.12) in the ITT population (Fig. 1 A).
The current density of p.I1498M showed a 59% reduction, whereas the other variants did not show statistically significant modifications (although p.R1636Q showed a trend towards reduction, P = 0.12).
No notable differences were observed, but BMI in males showed a trend of increasing with age (p=0.12).
Differences between groups were observed, as MSCs from COPD patients secreted significantly higher amounts of IL-6 and showed a trend towards higher IL-8 secretion (p=0.12) ( figure 3b ).
TGV showed a trend-level effect for the shorter-than-average sleepers ( P = 0.12).
Although the HIGH group showed a trend toward a higher CI post-ROSC, the differences did not reach statistical significance ( p = 0.12).
However, consistent with our observations after a single injury, SOCS3 MscKO muscles contained a higher proportion of fibers with a single central nucleus after two sequential injuries ( Fig 4I ; ** P < 0.01) compared to muscles from control mice which showed a trend towards a higher proportion of fibers with more than two centralised nuclei ( Fig 4I ; P = 0.12).
Single-sample gene set enrichment analysis (ssGSEA) analysis revealed an inverse correlation between CLDN18 expression and CD8 + T cells ( P = 0.012), while IHC showed a trend toward negative correlation between CLDN18.2 expression and CD8 + TILs density ( P = 0.12).
Analysis of dependency of BIS-reduction on daytime showed a trend for HGSHS-5 (BIS total intervention) with 88.8 at noon vs. 90.5 in the morning and evening ( p = 0.12).
Subgroup analyses showed a trend for the reduction in triglycerides in the EG to be larger at longer-term follow-up (i.e., 6–12 months; MD −0.16; 95% CI −0.37 to 0.04; p = 0.12; I 2 = 0%) than at 3 months (MD −0.06; 95% CI −0.27 to 0.15; p = 0.55; I 2 = 0%), but both effects were not significant ( Figure 5 ). 3.4.4.
2.7% of placebo (HR 0.61, 95% CI 0.38-0.99, P = 0.04), while nonfatal MI showed a trend toward reduction (2.9% vs. 3.9%, HR 0.74, 95% CI 0.51-1.08, P = 0.12).
Although not statistically significant, patients treated with ICIs showed a trend toward better prognosis (P=0.12) than those not treated with ICIs [18.4 months (95% CI: 8.2–28.6) vs. 7.7 months (95% CI: 0–17.7)] ( Figure 2B ).
When later events were included, both the REMoDL-B and LLMPP data showed similar results (OS HR = 2.11, 95% CI = 1.115–3.993; p = .019 and HR = 2.17, 95% CI = 1.109–4.242; p = .02; supplemental Figure 3 A,B, respectively), while the HMRN cohort showed a trend for reduced survival in the high-risk group, (HR = 1.39, 95% CI = 0.917–2.106; p = .12; supplemental Figure 3 C); and we have reasoned that the performance of the discriminator may reflect the number of non-lymphoma–related deaths in this population-based cohort.
In IPF, individuals in the lowest PCSK6 tertile showed a trend toward better survival (log-rank p = 0.12).
Among DLBCL cases, non‐GCB subtypes showed a trend toward greater SPSM diversity and shorter survival ( p = 0.12), though this difference was not statistically significant.
In contrast, in primary PCa, the Wnt pathway showed a trend towards increased activity (p = 0.12), and median FOXO activity was only slightly lower than in healthy tissue (p = 0.12) indicating that PI3K pathway activity was restricted to a subgroup of PCa.
Multivariate correlation analysis yielded no statistically significant results when comparing individual comorbidities to death (Figure 7 ) but showed a trend towards diabetes modestly decreasing survival (Pearson r=0.16; p=0.12).
Only the treated male mice showed a trend ( p = 0.12) to improved performance as indicated by an increase in spontaneous alteration rate.
(e) The ratio of open arm to total arm entries in the elevated plus maze showed a trend towards more open arm entries in J20 animals and a recovery of this in GluA2 G/G /J20 mice (Welch’s ANOVA W (3,29.15) = 2.12, p = 0.12; n’s : WT = 15, GluA2 G/G = 13, J20 = 16, GluA2 G/G /J20 = 14).