The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer's disease.

(e) The ratio of open arm to total arm entries in the elevated plus maze showed a trend towards more open arm entries in J20 animals and a recovery of this in GluA2 G/G /J20 mice (Welch’s ANOVA W (3,29.15) = 2.12, p = 0.12; n’s : WT = 15, GluA2 G/G = 13, J20 = 16, GluA2 G/G /J20 = 14).

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Here, we found J20 mice have a strong trend toward increased open arm entries as a ratio of total arm entries in the EPM, similar to what we have previously observed in this model [ 65 ].

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Mean spike frequency averaged over a 24 h period showed a clear trend towards increased number of spikes in the J20 and Gria2 G/G /J20 mice, though this was not statistically significant (ANOVA; F (3,15) = 2.9 p = 0.07; Fig. 3 b).

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