The addition of pembrolizumab was associated with a favorable trend toward improved event-free survival versus placebo plus CRT, but the difference did not reach statistical significance in the ITT population (the 24-month event-free survival rate was 63.2% for the pembrolizumab arm versus 56.2% in the placebo arm). 62 Currently, several clinical trials are exploring the role of different ICIs in LACC setting ( Table 1 ).
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While a direct comparison between isotype and anti-IFNγ treated mice inoculated with BCG prior to viral challenge did not reach statistical significance, animals treated with anti-IFNγ showed a clear trend towards more severe disease and higher viral loads (Fig. 2F, G ).
a positive trendgold
The association with contraceptive use showed a positive trend but did not reach statistical significance after adjustment (adjusted OR = 3.22, 95% CI: 0.94–11.04, p = 0.063) (Table 8 ). 3.10.
This did not reach statistical significance (p=0.29, χ 2 1.117) but showed an important trend, given the rarity of moderate, severe or catastrophic adverse incidents.
The cCMV group also showed a trend toward more specific clonotypes than the aCMV group, but this did not reach statistical significance (P = 0.086).
Only elderly women showed a trend towards better QOL in urban areas,s but the difference between urban and rural mean scores of SF-12 did not reach statistical significance.
a marginal trendgold
Authoritative parenting showed a marginal trend toward a lower episode rate, though this did not reach statistical significance (RR = 0.90, 95% CI 0.80–1.01, p = 0.065).
In Group I, GAL showed a trend to lower activity and lyso‐Gb3 to higher levels in women with the mutated X‐chromosome active compared to those with the mutated X‐chromosome inactive, however, differences did not reach statistical significance (Figures 2 and 4a,b ).
a positive trendgold
Among participants without diabetes, there was a positive trend of association between sarcopenia with lower fasting insulin, but this did not reach statistical significance, possibly due to the relatively large standard deviation ( p = 0.055).
Among patients with known CAD, the difference in MACE rates between patients with elevated PWV and those with non-elevated PWV showed a trend toward significance, but it did not reach statistical significance (p = 0.053).
Weight Our pooled studies at endpoints showed a trend towards higher weight with lifestyle interventions plus metformin; however, this did not reach statistical significance (SMD = 0.12, 95% CI [-0.03, 0.27], P = 0.11).
Compared to Q10, Q-Der consistently showed a trend toward better protection against oxidative stress markers such as mitochondrial superoxide, although this trend did not reach statistical significance.
Swallowing dysfunction showed a trend toward higher malnutrition risk (RRR = 4.07), though this did not reach statistical significance ( p = 0.070).
Similarly, there was an observed trend indicating that patients with PA with posttreatment PRA levels between 1 and 2 ng/mL per hour had a lower incidence of MACE compared with those with PRA levels either <1 ng/mL per hour or >2 ng/mL per hour; however, this trend also did not reach statistical significance.
A decreasing trend was observed in %PMI loss in the group with anastomotic stenosis; however, this did not reach statistical significance (Figure S1B ; p = 0.259).
In contrast, CD86 expression showed a decreasing trend but did not reach statistical significance ( Fig. 5 D).
PASE did not reach statistical significance, but we found an Odds Ratio of 0.51 95% CI 0.25–1.03 p value 0.062 ( Table 4 ), this founding may underline an interesting trend. 4.
Although performance scores showed a trend towards improvement, this difference did not reach statistical significance, suggesting that both methods provided comparable levels of perceived task accomplishment and indicating that the reduction in workload did not compromise planning quality.
Although AT2 cells showed a decreasing trend in In-F, the difference did not reach statistical significance, and AT1 cells did not show a consistent reduction in spatial abundance.
Patients with FIGO stage IB2 to IIA2 disease who underwent ORH showed a trend for e better PFS compared to MIRH patients (90.5% vs 60.0%), although this did not reach statistical significance ( P = .107) (Fig. 2 E).
They showed a trend for a higher miscarriage rate in the high SDF group, but it did not reach statistical significance.
Although the difference did not reach statistical significance, a favorable trend toward improved wound closure was observed in the GPP@VP NIR group.
For EPM, however, the time spent in open arms showed a trend to decrease in the DCP-treated mice compared with controls, but it did not reach statistical significance ( Fig. 1D ).
6-methyl-5-heptan-2-one and geranylacetate showed a trend toward increased responses in starved flies but did not reach statistical significance (data not shown).
a positive trendgold
The correlation between D13 and state anxiety showed a positive trend but did not reach statistical significance ( p = 0.052) (Table 3 ).