T3 concentrations were significantly higher in the eggs laid under the poor food condition and the total T3 content also tended to be higher although this did not reach statistical significance (T3 concentration, P = 0.0006.
The negative relationship between proportion of activated (CD38/HLA-DR) CD8 + T cells and CD4 counts did not reach statistical significance ( Figure 7E ), but proportion of activated (CD38/HLA-DR) CD8 + T cells were positively correlated with HIV plasma viral loads among viremic PLWH (r=0.8, p=0.0006; Figure 7F ).
Additionally, three other pairs of traits did not reach statistical significance but showed genetic covariance with Benjamini-Hochberg false discovery rate (fdr) below 0.1, including BMI and MC-FS (covariance = -0.035; p = 6.4e-4), high-density lipoprotein cholesterol (HDL-C) and FC-MS (covariance = -0.058; p = 8.2e-4), and total cholesterol (TC) and FC-MS (covariance = -0.063; p = 5.1e-4).
When the RAR was converted to a quartile variable, participants in the Q2 had a 1.18-fold increased risk of developing osteoarthritis compared to the Q1 (OR = 1.18, 95% CI: 0.89, 1.57, P = 0.2492), but did not reach statistical significance; participants in Q3 had a 1.65-fold increased risk (OR = 1.65, 95% CI: 1.24, 2.20, P = 0.0007), which was statistically significant; and participants in Q4 had a 1.97-fold increased risk (OR = 1.97, 95% CI: 1.42, 2.73, P < 0.0001).
In the non-classical T lymphocyte subset, γδ T cells were increased in decidua compared to PBMC but did not reach statistical significance unless only third trimester animals were compared (two-tailed unpaired t-test, p-value = 0.0008) ( Figure 4A ).
For renal function, the overall difference in eGFR across clusters did not reach statistical significance after FDr adjustment (P FDR = 0.088); post hoc pairwise comparisons indicated that SIDD had lower eGFR than SIRD ( p = 8.49 × 10 −4 ), and SIRD had lower eGFR than MARD ( p = 0.01), while other comparisons were not statistically significant ( Supplementary Table S1 ).
Although the treated groups also exhibited an increase, the change did not reach statistical significance compared with that of the CPZ + Vehicle group ( P = 0.0009) (interaction F (8, 50) = 3.850, P = 0.0014; time F (1.876, 46.91) = 17.61, P < 0.0001; treatment F (4, 25) = 8.022, P = 0.0003; Fig. 2 D).
Kaplan Meier analysis revealed a significantly reduced risk of all-cause mortality, while the reduction in composite kidney outcome showed only a trend and did not reach statistical significance ( P = 0.00095, P = 0.065, respectively).
Another GSDMB SNP rs11078927 (intronic) showed similar findings with asthma but did not reach statistical significance (p = 9.5×10 -4 , z = -3.23) although this SNP was significantly associated with FEV 1 (% Predicted) (p = 8.7×10 -4 , z = -3.33).
Although this difference did not reach statistical significance, a significant main effect of time was observed (F(1, 28) = 15.00, p < 0.001, ηp 2 = 0.349; Figure 6 ), accompanied by a moderate effect size.
Although the association of fetal disease (column 1) and neonatal malformation (column 2) did not reach statistical significance, neonatal disease (column 3) remains statistically significant ( P < .001) with an odds ratio of 1.15.
In the multivariate model for OS, RCB‐III remained an independent adverse prognostic factor (HR: 19.078, 95% CI: 4.127–88.183, p = 0.002), whereas RCB‐I and RCB‐II did not reach statistical significance. For disease‐free survival, univariate analysis showed that pCR was strongly associated with improved DFS (HR: 0.073, 95% CI: 0.028–0.187, p < 0.001).
Although differences in mobility, self-care, and usual activities did not reach statistical significance, the EQ-5D index score was markedly lower in the MD cohort than in the controls (median 0.66 [IQR 0.45–0.94] vs. 1.00 [IQR 0.69–1.00]; p < 0.001, Mann–Whitney U test), indicating a substantial reduction in overall health utility associated with MD. 3.3.
Values did not reach statistical significance, with the exception for CD45R0 (adj p = 0.001) and CD20 (adj p = 0.012), higher in the adjacent liver of non‐dHGP metastases.
NgR1 , Lingo1 and Troy significantly decreased at 28 dpi compared to control animals, while p75 mRNA levels did not reach statistical significance, supporting the duality of this receptor complex ( Figure 4 A, p < 0.001 vs. control; Figure 4 B,D, p < 0.05 vs. control).
In addition, the difference between stage III–IV and stage I–II patients did not reach statistical significance after adjustment ( P = 0.001, Padj = 0.006).
Regarding the LPP, although the context-by-time interaction did not reach statistical significance in the quadratic model, simple slopes analyses indicated that the time effect remained significant in the gain context, b = −0.75, z = −3.93, P < .001, but not in the loss context, b = −0.34, z = −1.78, P = .075, a pattern consistent with the primary linear analysis.
Lipid accumulation in liver Although the difference in hepatic cholesterol between animals fed the control and HF–HS diets did not reach statistical significance, the HF–HS diet elevated hepatic triglyceride levels by 135% ( P < 0.001) at week 2 and 42% ( P < 0.05) at week 4 (Figure 4 A).
However, specific organ affection by systemic emboli did not reach statistical significance between groups, with the exception of pulmonary embolism, associated with Staphylococcal IE ( p = 0.001).
While spearman correlations of ∆ aY with d y (rho = −0.45) and Δ Y (rho = 0.11) did not reach statistical significance, the HCE growth rate of adults Δ A showed a strong, statistically significant correlation with ∆ aY (rho = 0.81, p-value < 0.001).
Significant differences were observed between Grade 2 and Grade 4 in VAS ( p = 0.013), ICOAP-constant pain score ( p = 0.041), ICOAP-total score ( p = 0.047), TUG ( p = 0.025), and KOS-ADLS ( p = 0.055, borderline significance), while quadriceps muscle strength of the affected knee did not reach statistical significance in this comparison ( p < 0.001 indicates strong significance depending on direction) (Table 3 ).
There was an overall trend indicating an increased risk of preeclampsia in women with vitamin D deficiency compared to those with sufficient levels, but the findings did not reach statistical significance p -value<0.001 (OR 1.25, 95% CI 0.89–1.76, I 2 = 86.7%;, random-effect).
Confirmed cases had higher serum lactate dehydrogenase levels than controls but the difference did not reach statistical significance (median 280.0 U/L vs 194.0 U/L, P = 0.001).
For students in the Americas, the effect did not reach statistical significance (SMD = 1.82, 95% CI = −0.24 to 3.88, I2 = 99.3%, P < .001) ( Figure 3F ).
Higher histology stages of 3 and 4 were associated with higher mean biomarker levels, but this difference did not reach statistical significance regarding reported history of schistosomiasis infection, telomerase levels were significantly higher among those with schistosomiasis ( p < 0.001), but no such difference was found in terms of CD44 ( p = 0.768) or NMP22 levels ( p = 0.375).