The difference between men and women in the proportions of cavus (men 31.6%, women 29.0%) and planus (men 29.0%, women 24.3%) foot posture did not reach statistical significance, yet the difference in proportions of foot function did ( P < 0.0001).
In the subgroup with low or intermediate risk of recurrence the differences in the recurrence-free survival did not reach statistical significance (p = 0.36), however, in high-risk cases there were highly significant differences among the surgical groups (p <0.0001, Figure 2 ).
In addition, in an in vivo experiment including the treatment of non-targeting PG CAR-IL15 T cells, no significant body weight loss was seen in the mice of this group, although we indeed observed a trend toward slower tumor growth in those treated mice from Day 18 after treatment, which did not reach statistical significance (mean tumor volume on Day 21: 39.5 vs 454.1 or 301.7 mm 3 for H9 CAR-IL15 vs UN-T or PG CAR-IL15, p < 0.0001; Figure S4F ); this observation is possibly explained by the fact that IL-15 itself produced from non-activated CAR-T cells may induce the antitumor activity when it accumulates to a certain level, which is consistent with previous studies showing that IL-15 has modest anticancer activity as a single agent ( 24 ).
Lower PlGF MoM and higher MAP MoM were also found in LO-PE pregnancies, however the difference in PlGF MoM did not reach statistical significance (MAP –1.05 MoM, p<0.0001; PlGF –0.90, p = 0.024).
At wave 2, all three scales were positively correlated; however, the correlation between neighborhood social ties and neighborhood safety was low in magnitude (0.031) and did not reach statistical significance (both other correlations were significant at the p < .0001 level).
While the improvement within the SOD group was highly significant (p < 0.0001), the between-group difference (~11%) did not reach statistical significance (p = 0.089), possibly due to limited power and smaller-than-anticipated effect size [ 7 ].
While differences in individual proteins did not reach statistical significance, overall, a greater number of proteins were elevated in the higher diversity group relative to the lower diversity group (Fisher’s exact test, P < 0.0001).
Although DOX-treated animals exhibited a downward trend in body weight over time, vitamin D-treated groups showed a partial attenuation of this pattern; however, these differences did not reach statistical significance ( Figure 1 ). 3.2. 99 mTc-PYP Uptake in Liver Hepatic 99 mTc-PYP uptake differed significantly among the experimental groups (F(5,36) = 57.97, p < 0.0001, R 2 = 0.8895).
All CA mutants showed impaired transduction efficiencies in CD4 + T cells, in which CypA is an LV promoting factor, despite similar infectivity as the wild-type (WT) vector in 293T cells ( Supplementary Table S1 ) ( Figure 6a , white bars, mutants versus WT, P < 0.0001 for all except A92E which did not reach statistical significance).
In our study, internal adenomyosis was more frequent but did not reach statistical significance, with a disrupted and ill-defined junction zone, characteristic especially of internal adenomyosis ( p = 0.0001).
Although the primary analysis did not reach statistical significance, the update analysis showed an OS benefit of apalutamide (median OS not reached v 52.2 mos; HR 0.65; 95% CI 0.53–0.79; p < 0.0001) despite crossover that was allowed in the study [ 209 ].
Furthermore, treatment with perampanel caused a significantly decreased cell viability only in NCH620, while the reduction observed for NCH645 did not reach statistical significance (NCH620 32.4%, p < 0.0001; NCH645 12.3%, p = 0.135; Figure 2 ). 3.2.
Meta‐Analysis of Butyric Acid Concentration in Patients With Periodontitis Meta‐analysis indicated an overall decreasing trend in butyrate levels in GCF or saliva from patients with periodontitis; however, the difference did not reach statistical significance (SMD = −1.58, 95% CI: −6.53 to 3.36) and heterogeneity was substantial ( I 2 = 90.9%, p < 0.0001; Figure 3 A).
The use of mifepristone showed a reduction in the use of oxytocin (RR = 0.84; 95% CI: 0.70–1.01), although this difference did not reach statistical significance ( p = 0.065), and a highly significant reduction in prostaglandin use (42.7% vs. 78.9%; RR = 0.54; 95% CI: 0.48–0.60; p < 0.0001), with no significant difference in cesarean section rate (18.9% vs. 23.6%; RR = 0.80; 95% CI: 0.63–1.01; p = 0.068).
Although the changes between individual phases (T1 through T5) did not reach statistical significance, the main effect of experimental phase was highly significant ( p < 0.0001).
Weak negative and positive trends were observed between “Junk food” (rho = −0.19, p = 0.003) ( Figure 4 D) and “Beans” (rho = 0.17, p = 0.008) ( Figure 4 E), respectively, and EPA levels, although their p values did not reach statistical significance using the cutoff point of p = 0.00016.
It is not unexpected that race did not reach statistical significance in the stratified analysis, even though it was a strong predictor in the non-stratified model ( Table 1A , p = 0.0002).
MR associations between genetically proxied GP6 and overall stroke risk and ischemic stroke risk showed the same direction as cardioembolic stroke but did not reach statistical significance after multiple testing correction (OR wald ratio , 1.63 [95% CI, 1.25–2.13]; P =3.7×10 −4 ; FDR=0.22; Figure 2 ; Table S3 ).
were elevated in participants receiving SCF compared to placebo, but this did not reach statistical significance after correcting for multiple comparisons ( p = 0.0004, FDR q = 0.073, ANCOMBC).
GFP lo cells appeared reduced in gata2a um27/+ embryos at 56 hpf, however, this did not reach statistical significance when compared to WT ( Figure 2H ), nonetheless, Pearson’s correlation again suggested a contributing effect across genotypes (Pearson r = − 0.55, p = 0.0004).
While the moderator analysis did not reach statistical significance, subgroup analysis showed a significant difference in occlusion rates between FD and coiling (χ 2 = 12.59, p = 0.0004).
These findings reflect acute acid–base disturbances triggered by the rapid volume shift, even though the overall group comparisons did not reach statistical significance. Due to hemodilution, the blood lactate concentration in the ANH group increased markedly at the T 1 time point ( p < 0.0004), likely due to hypoperfusion-induced anaerobic metabolism, and remained elevated at the T 2 time point compared to the control ( p = 0.0018) and sham ( p = 0.0157) groups ( Figure 2 D).
Although the CGGGG indel did not reach statistical significance independently in all three cohorts, the combined analysis revealed a clear association signal between the CGGGG indel and MS (p = 0.0005), with the longer allele (4×CGGGG) as the risk allele.
IL-6 Receptor sIL6R showed a suggestive modest negative effect on COVID-19 outcomes (ORs ranging 0.94 to 0.97) ( Figure 4 ), but these did not reach statistical significance, except for COVID-19 infection, i.e., HGI_ALL_C2 ( p = 0.0005). 3.3.
MaAsLin2 analysis revealed a higher relative abundance of Eggerthella in the cranberry group at week 6, although this association did not reach statistical significance after multiple testing correction ( p = 0.00052, q = 0.0976).