“did not reach statistical significance”

29 Smoking, a well-recognized associated factor for heart disease, showed a trend toward higher prevalence of heart disease, however, this association did not reach statistical significance in our analysis.

Measurement of NF-κB activity in SF3B1 WT and SF3B1 K700E cell lines showed a trend towards an increase of the active p65 form and of the ratio between phosphorylated p65 and total p65 in SF3B1 K700E samples, although they did not reach statistical significance ( Fig 5D and E ).

However, the adjusted model showed a trend towards improved survival in patients using anticoagulants, though this did not reach statistical significance.

Although the c-MET IHC distribution pattern ( p = 0.068) and initial brain metastasis ( p = 0.061) showed a trend, the findings did not reach statistical significance.

U50,488H, MOM-SalB, and 42B induced significant KOR phosphorylation at T363, whereas nalfurafine, even at 30 μg/kg, showed a trend of increase, but did not reach statistical significance.

Although there was a decreasing trend in overall appropriateness over the monitoring time ( Figure 6 ), this trend did not reach statistical significance. 4.

Consistently, LPC 18:2 markedly increased Il17a and Il17f mRNA expression and showed a trend toward higher Rorc levels, although the latter did not reach statistical significance ( Fig. 5 E ) .

An increasing trend was observed in the number of junctions and nodes and the total length of the network, although it did not reach statistical significance.

A recent observational study on acetylsalicylic acid use and iFOBT performance showed a trend towards an increase in sensitivity (from 51.2 to 66.7%) without loss of specificity in acetylsalicylic acid or NSAID users, but the difference did not reach statistical significance, likely due to a relatively low number of acetylsalicylic acid/NSAID users [ 20 ].

The proliferative function showed a decreasing trend in mid-old cells, but did not reach statistical significance, while old cells exhibited decreased functional indices and proliferation capacity, along with a significant upregulation of inflammatory response (Fig. 1e and Supplementary Fig. 3b ).

It is of note that, among the MASLD cohort, there was an overall trend of consuming more refined grains (refined wheat: 0.69 ± 0.99 vs 0.66 ± 0.39 g/kg/d; refined rice: 0.19 ± 0.02 vs 0.13 ± 0.11 g/kg/d) compared with whole grains (wholegrain wheat: 0.23 ± 0.3 vs 0.31 ± 0.34 g/kg/d; wholegrain rice: 0.04 ± 0.12 vs 0.03 ± 0.05 g/kg/d), but the differences did not reach statistical significance.

Although rh KAI1 treatment showed a trend toward increased muscle mass, these changes did not reach statistical significance when assessed by gross weight measurement.

A higher LMR (≥ 3.0) showed a positive trend but did not reach statistical significance in adjusted models.

Although NCD status showed a positive trend, it did not reach statistical significance after adjustment.

Two other studies [ 23 , 24 ] showed a trend towards quicker coverage for DAP; however, they did not reach statistical significance.

While both mMRC score ≥2 and radiological progression showed a trend toward increased mortality risk, these associations did not reach statistical significance as shown in Table 4 .

The pertuzumab-alone group showed a trend toward an increased apoptotic cell population but did not reach statistical significance.

Notably, some clinicopathological factors showed a trend toward differences between molecular subtypes, although they did not reach statistical significance.

While our study did not reach statistical significance, it did reveal a notable trend indicating that longer LOS is associated with poorer radiological outcomes.

The deletion of iscR showed a trend to attenuate the bacterial virulence; however, the difference did not reach statistical significance.

For the 1.0-mm, only the 1.65-mm and 5-mm depths were available; the increase in RMS from 24.1 ± 2.5 μm to 42.7 ± 13.8 μm showed a trend towards higher values at 5 mm but did not reach statistical significance ( p ≈ 0.070).

The funnel plot ( Figure 3 ) and Egger’s test revealed no evidence of small-study effects or publication bias across all subgroups, with the exception of the DM subgroup, in which a weak trend towards small-study effects was noted; however, this did not reach statistical significance ( p = 0.0746).

QoL outcomes showed a positive trend favoring TCM combination therapy (SMD: 0.82, 95% CI: -0.17 to 1.81), although this did not reach statistical significance.

Kaplan–Meier survival curves ( Figure 9 ) showed a trend toward improved survival in the High/Medium AHR group; however, the difference did not reach statistical significance (log-rank p = 0.276).

Stratification by age groups (Q1 < 40 years; 40 ≤ Q2 < 59 years; Q3 ≥ 59 years) showed a trend of enhanced potential association between LAP and depression in the elderly population (Q3 group), although the interaction did not reach statistical significance (P for interaction = 0.068).