“did not reach statistical significance”

Similarly, the SWOG 9900 trial, published in 2010, showed a trend toward improved OS with neoadjuvant carboplatin–paclitaxel chemotherapy in patients with stage IB-IIIA disease, though these results did not reach statistical significance, as the trial was closed early, due to adjuvant chemotherapy becoming the standard of care while the trial was still in process [ 9 ].

A subgroup analysis of ACS-presenting patients showed a trend toward an increased incidence of the primary composite endpoint in patients randomised to the short DAPT group but did not reach statistical significance (p=0.158).

A decreasing trend in NKT cell migration was observed in the sh-TACC2 group; however, the difference did not reach statistical significance (Supplementary Fig. 8 D).

While the secondary endpoints did not reach statistical significance, but showed a positive trend in favor of the ER2EP pathway ( Figure 2 ).

For mandibular range of motion (ROM), the overall repeated-measures model demonstrated a significant main effect of time (GEE p = 0.008), while the group effect was not significant ( p = 0.554) and the Group×Time interaction showed a trend but did not reach statistical significance ( p = 0.070).

In our study, full-field VEP measurements showed a trend towards attenuation of the VEP signal upon ocular hypertension, yet did not reach statistical significance, perhaps due to limitations in detection.

In women, gait speed-based sarcopenia definitions were weakly significant (OR = 1.98, CI: 0.96–4.09), but most other models did not reach statistical significance.

The complex I activity in Cdkl5 +/− heart mitochondria showed a trend of reduction compared to controls, although it did not reach statistical significance ( Figure 5 D).

The accumulated concentration of exhaled CO showed an increasing trend with increasing ribavirin treatment dosage, though the group differences did not reach statistical significance.

At the same time, the mean values of fasting blood glucose also showed a trend of being higher in the case group than in the control group, but these differences did not reach statistical significance.

Specifically, benralizumab demonstrated a borderline significant reduction in exacerbation risk (rate ratio 0.92; 95% CI: 0.85-1.00), while mepolizumab exhibited a trend toward lower exacerbation risk that did not reach statistical significance (rate ratio 0.90; 95% CI: 0.77-1.06) ( 44 ).

Finally, although phloretin showed a protective trend, its effect on functional recovery, such as grip strength, did not reach statistical significance in the LLC model and was only modestly significant in the C26 model.

In the independent GEO cohort GSE39582 , DMBX1 expression showed a trend toward higher levels in colorectal cancer tissues compared with normal mucosa, although the difference did not reach statistical significance (Wilcoxon rank-sum test, p = 0.083).

In the SMG versus NG comparison, the KEGG oxidative phosphorylation pathway (mmu00190) also showed enrichment (NES = 1.56, p = 0.003), though this did not reach statistical significance after FDR correction (FDR = 0.468), suggesting a possible trend toward increased oxidative metabolism.

GTT of the db/db - mg53 −/− mice showed a trend of reduced glucose tolerance compared with db/db littermates, but the difference did not reach statistical significance.

RT-qPCR results demonstrated that the mRNA expression levels of ACACA and ACLY in the Sj group were significantly higher than those in normal liver tissues ( P < 0.05), and the mRNA expression of all three genes showed a trend of “Sj group > HBV group > normal control group” (though the intergroup differences did not reach statistical significance).

On the other hand, binding of rEgAgB8/2 to macrophages was not observed; the binding index showed a trend to increase in a dose dependent manner, but this trend did not reach statistical significance (Fig. 4a ).

Days since hospitalization showed a positive trend but did not reach statistical significance at this stage ( p = 0.081) ( Supplementary Table S4 ).

They showed a trend for a higher miscarriage rate in the high SDF group, but it did not reach statistical significance.

Although performance scores showed a trend towards improvement, this difference did not reach statistical significance, suggesting that both methods provided comparable levels of perceived task accomplishment and indicating that the reduction in workload did not compromise planning quality.

Only elderly women showed a trend towards better QOL in urban areas,s but the difference between urban and rural mean scores of SF-12 did not reach statistical significance.

Postoperative TSH and preoperative FT3 levels showed a trend toward lower values in the non-survivor group; however, these differences did not reach statistical significance.

The proportion of Type IIb muscle fiber showed a decreasing trend but did not reach statistical significance when compared with the control group.

Despite an average duration of disease of 10 years since the TM attack initially occurred, we found that the drug showed a trend in improving walking speeds in 85% of individuals while receiving D-ER versus 69% while receiving placebo, and met the higher threshold for responder in 33% while receiving D-ER versus only 8% while receiving placebo, although, given the small numbers of participants, this percentage did not reach statistical significance ( p = 0.33).

After 12 h of treatment with 0.2 μM of LLL12, SCCF2 showed a trend towards increased caspase 3/7 activity (data not shown), but this difference did not reach statistical significance until 24 h of treatment.