Barely Significant
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“borderline significance”

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borderline significancep=0.0511.0× alpha
A lack of PLND (HR, 0.401; 95% CI, 0.187 to 0.860; p=0.019), higher FIGO stage (HR, 1.625; 95% CI, 1.045 to 2.527; p=0.031), and LVI (HR, 2.280; 95% CI, 1.134 to 4.583; p=0.021) remained significant in the multivariate analysis, whereas PALN metastasis exhibited borderline significance (HR, 2.297; 95% CI, 0.995 to 5.303; p=0.051) ( Table 3 ).
borderline significancep = 0.0511.0× alpha
Statistical appraisal by means of Egger’s test of regression produced a significant intercept ( β 0 = 2.34, 95% CI: 0.68–4.01, p = 0.008), suggesting funnel plot asymmetry beyond chance, and Begg’s rank correlation test revealed borderline significance (Kendall’s τ = 0.31, p = 0.051), offering supporting evidence for possible publication bias.
borderline significancep = 0.0521.0× alpha
Unexpectedly, although with borderline significance ( p = 0.052), there was lower FREM2 expression in LGG patients who progressed during first-line temozolomide treatment and had an IDH mutation versus patients with IDH -mutant stable/responsive disease; whereas there was no difference in IDH -WT patients ( Figure 6 ).