“a marked trend”

Despite a marked trend towards decreased O 2 in dead animals, their tumour areas produced phosphorescence lifetime values between 44 and 47 μs, which corresponded to hypoxic tissue with 5–20 μM O 2 .

Analysing all timepoints together in an unpaired analysis, there was a marked trend towards higher CXCL1, IL-8, IP-10 and lactoferrin during infection.

The results confirmed that there was a marked trend of increasing cell viability and almost no dead cells were detected in all groups.

A marked trend towards improvement in central conduction time was only observed in the subgroup of patients whose CMCT at t 0 showed a marked alteration in CMCT, with values above 140% of the normal limit value (12 milliseconds in EESS and 23.43 in lower limbs) compared to those who preoperatively had a TCC within normal limits ( p = 0.069 in univariate analysis of variance).

In addition, the authors found that patients with a history of cerebrovascular disease and hypertension also had a marked trend associated with CAPA [ 65 ].

By day 28, the treatment group showed VSC concentrations that were significantly lower than the placebo group ( p < 0.001), and although still higher than the healthy baseline ( p < 0.05), they demonstrated a marked trend toward normalization.

There was a marked trend towards lower expression of HLA-DR and HLA-A, B, and C on mDCs and pDCs of MM patients compared to HDs ( 41 ).

However, in the case of severe diseases, there is a marked trend toward seeking treatment in tertiary, specialized hospitals.

They found a marked trend for the association between the IL-4 -590 C > T polymorphism and PE [ 30 ].

Furthermore, there was a marked trend for PRL, E 2 , IL-1α, IL-2, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, eotaxin, G-CSF, IFN-γ, KC, MCP-1, MIP-1α and RANTES to decrease on day 2 of lactation.

A marked trend was detected, with most neuronal signaling gene profiles overexpressed in fasted pigs relative to controls and underexpressed in immunostimulated pigs relative to controls (Table 3 ).

Total cholesterol showed a marked trend toward a decrease (pooled MDΔ = −0.127 mmol/L; 95%HPD = −0.284; 0.014) and high-density lipoprotein (HDL) cholesterol remained substantially stable (pooled MDΔ = 0.002 mmol/L; 95%HPD = −0.140; 0.147).

There was a marked trend for the association of emotional problems and nail biting (Table 6 ).

Notably, treatment with 60 μM D-cycloserine exhibited a marked trend toward restoring LTP in these interneurons, although statistical significance was not yet achieved—possibly due to the need for higher concentrations or prolonged pre-incubation.

Types of tissue and preparation In recent years, a marked trend toward lamellar keratoplasties has been observed.

Although FEV 1 did not show significant differences, there was a marked trend reduction on top of a significant reduction in D LCO in the COPD-PH group that could explain this difference which directly influences ventilatory capacity and exercise tolerance.

The results showed that the highest temperature and heating rate were nearly identical in every cycle, rather than following a marked trend, signifying the high photothermal stability of Dox@TPAu.

There was a marked trend towards a higher tumour incidence in Limk2-KO mice ( figure 9 F).

During the same period, there has been a marked trend of delays in herders’ arrivals to the Nes clinic.

At present there are three main separated areas in this region, representing isolated clusters, which may confirm that in Poland its occurrence range is rather disjunctive, with a marked trend towards gradual decline in the number of localities 25 , 27 .

The remarkable changes that have occurred in dietary habits throughout past centuries are mostly characterized by a shift towards a sodium-rich diet (i.e., a potassium-to-sodium intake ratio usually < 0.4), and have also been associated with a marked trend towards sodium overload and potassium depletion 17 with significant adverse cardiovascular effects 18 .

A few countries show a marked trend for recording species earlier, namely Japan, the USA, Philippines, and Thailand (THA), whereas countries where alien fishes are consistently recorded later include Haiti, Cambodia (KHM), and Tunisia (TUN) ( Fig. 2 B ).

Despite our efforts to synthesise better-ordered crystal phases, the structural disorder seems to be a marked trend in these cubic systems.

Fatty pig breeds, as Mangalitsa, are characterized by a marked trend for fat accumulation and are usually considered adequate animal models to better understand the fattening processes, obesity and metabolic disorders, the Iberian breed being the most studied one [ 53 , 54 , 55 ].

At high shear rate, there was a marked trend toward reduced thrombogenicity that did not reach statistical significance [19.6% reduction in median thrombus from 8788 (1325) μm 2 /mm to 7066 (2516) μm 2 /mm, P = 0.176] ( Fig. 3A ).