“a marked trend”

Between 2014 and 2017, rice of European origin showed a marked trend for certain pesticides that exceeded MRLs, such as in the case of isoprothiolane or carbendazim.

We noted a marked trend toward increased abundance of M‐MDSCs following progression (Fig. 3G ); however, this did not reach statistical significance ( P adj = 0.0537). 3.6 PD‐L1 expression is upregulated on T cells during oleclumab/durvalumab treatment We subsequently performed differential analyses of cell state marker expression levels to investigate inter‐group differences and longitudinal changes in the activation, exhaustion, or terminal differentiation of leukocytes, as well as in the activity of signaling pathways potentially influenced by inhibition of adenosinergic signaling [ 30 ].

In Seychelles, the prevalence of diabetes increased by 50 % in 15 years with half of cases attributable to obesity [ 8 , 9 ], and a marked trend for diabetes to cluster among those of low SES [ 10 ].

Compared with the 2010 measurement by Warner et al.,(2013)—when the water table stood at about 12.00 m 37 with a mean electrical conductivity of 2 376 μS/cm and mean TDS of 1 751 mg/L—the 2022 survey reveals a marked trend toward both drawdown and salinization: the average depth has increased to 19.39 m, mean EC has risen to 4 590 μS/cm (an increase of 93%), and mean TDS has climbed to 4.31 g/L (an increase of 146%).

Hence, control flies had a marked trend to end in positive optomotor positions, whereas SoxD-RNAi flies showed no preference (Fig. 5C ).

In public health, there has been a marked trend toward open data and sharing code—notably during the COVID-19 pandemic (Moorthy et al. 2020 ).

Considering that the RNA viruses have a marked trend to mutate, the possibility that the general population will be forced to be vaccinated every year towards the prevalent circulating variant, as with influenza, is a likely scenario.

Upon metabolomic analysis, 37 metabolites in control, model and paeoniflorin groups had maintained a marked trend of “low-high-low” or “high-low-high,” such as valine, tyrosine, 9,12,15-Octadecatrienoic acid, glutamine, Leukotriene B4, and glutamic acid (Supplementary Figure S1 and Supplementary Tables S1 , S2 ).

A marked trend was seen with increasing levels of both markers of inflammation with higher POP exposure.

Interestingly, in fungi, a marked trend toward hypomethylation is observed for TEs located within 1-kb of expressed genes, rather than segregated in TE-rich regions of the fungal genome [ 69 ].

The changes in climate that have been observed all over the world indicate a marked trend toward higher temperatures accompanied by reduced annual precipitation [ 1 ].

In the past five years, there has been a marked trend to automate these surveillance activities to reduce the cost and possibly improve the performance.

For example, on the one hand we find relationships without either a marked trend or substantial variability among cities (for example, prostate cancer in men).

Despite a marked trend towards decreased O 2 in dead animals, their tumour areas produced phosphorescence lifetime values between 44 and 47 μs, which corresponded to hypoxic tissue with 5–20 μM O 2 .

While the Lactobacillus genus was shown to elicit a slight and statistically non‐significant increase in relative abundance, the Bifidobacterium taxa showed a marked trend of numerical enhancement during the eight weeks of treatment, thus supporting the bifidogenic effect of this specific FOS component.

The results confirmed that there was a marked trend of increasing cell viability and almost no dead cells were detected in all groups.

A marked trend towards improvement in central conduction time was only observed in the subgroup of patients whose CMCT at t 0 showed a marked alteration in CMCT, with values above 140% of the normal limit value (12 milliseconds in EESS and 23.43 in lower limbs) compared to those who preoperatively had a TCC within normal limits ( p = 0.069 in univariate analysis of variance).

Like Cho and colleagues, they noted a marked trend toward diminished acute GVHD in recipients with the AA (low VDR activity) genotype.

Based on this philosophy, we have observed a marked trend shift from laparotomy to laparoscopy in our department, a university teaching hospital.

In addition, the authors found that patients with a history of cerebrovascular disease and hypertension also had a marked trend associated with CAPA [ 65 ].

In addition, patients with a mixed type of IBS could be enrolled if they showed a marked trend of constipation on the symptom severity questionnaire.

In this digital, dynamic and constantly evolving environment there is a marked trend toward an economic system in which customer prioritization may dominate business relationships (Libai et al., 2020 ).

There was a marked trend towards lower expression of HLA-DR and HLA-A, B, and C on mDCs and pDCs of MM patients compared to HDs ( 41 ).

The results showed that the highest temperature and heating rate were nearly identical in every cycle, rather than following a marked trend, signifying the high photothermal stability of Dox@TPAu.

Fatty pig breeds, as Mangalitsa, are characterized by a marked trend for fat accumulation and are usually considered adequate animal models to better understand the fattening processes, obesity and metabolic disorders, the Iberian breed being the most studied one [ 53 , 54 , 55 ].