“a marked trend”

There is a marked trend to larger partnerships in primary care practices and more flexible working practices.

Nevertheless, there is a marked trend towards an increasing incidence of early onset CRC (less than 50 years) which has, unfortunately, obscured the positive outcome shown by the group of more than 50 years of age, which has shown a decrease in its incidence rates ( 1 ).

( 9 ) found a marked trend toward antimicrobial drug resistance among Mexican isolates.

The heatmap showed that eight of the overlapping and differentially changed metabolites have a marked trend of “high–low–high” or “low–high–low”, such as 11-dehydrocorticosterone, 9,10-EpOME, 12,13-EpOME, rhapontigenin, Glu-Thr, and phytosphingosine, which were deemed as key serum metabolites in SW033291-ameliorated T2DM.

46 , 47 Regimens combining VEGFR‐TKIs and ICIs for the treatment of mRCC did not show a marked trend toward an increased frequency of proteinuria with the addition of ICIs (Table 2 ).

Indeed, a marked trend exists in the development of region/population-specific small-area deprivation indexes for health research.

The fetal mortality ratio during the study period was 0.96%, with the highest rate in 2003 (13.7 per 1,000 births) and the lowest in 2016 (6.1 per 1,000 births), without showing a marked trend.

Lymphoma incidence showed a marked trend towards lower rates with increasing deprivation, entirely due to Hodgkin lymphoma (HL).

The results of this study, with no increase in incidence of cervical cancer with estimated arsenic concentration, but with a marked trend to a higher grade (poorly differentiated) at higher arsenic concentrations, cannot offer insight into mechanisms, but only demonstrate that arsenic does affect the disease process.

There is a marked trend to spontaneous improvement of the acetabulum after reduction, even in patients aged over 18 months and therefore simultaneous pelvic osteotomy is not always necessary.

PPL-101 (0.3–3.0 mg/kg; Figure 7 ) showed a marked trend to reduce operant responding for morphine.

In a multivariate model for MFS, the adherence showed a marked trend toward a significant prognostic factor (adjusted hazard ratio: 2.464; 95% CI: 0.876–6.932).

Similarly, AphPHYA-B1-GFP driven by the ApuPHYA promoter ( Pro ApuPHYA-B2 ::AphPHYA-B1-GFP ) showed a marked trend toward increased submergence-induced protein accumulation compared to Pro AphPHYA-B1 ::AphPHYA-B1-GFP (Fig. 5k and Supplementary Fig. 5b, c ).

Arginine had a marked trend towards a significant sex interaction with OS ( p interaction = 0.07), and a significant sex interaction for RFS ( p interaction = 0.04) ( Table S13 ).

Furthermore, a marked trend of increased Smad7 expression was found in HFD-P compared to CT-P mice ( Figure 7 E).

Even though our previous study, where we administered 5 mg/kg BW resveratrol in combination with equal amounts of quercetin and catechin, demonstrated reduced tumor growth and metastasis [ 26 , 34 ], in this study we found resveratrol alone induced a marked trend of increase in tumor growth, especially by the lower concentrations; thus, indicating a deleterious effect of resveratrol on breast cancer progression.

As a final note on insulin secretion, we observed a marked trend toward lower secretion in the DJ 3-OMG group.

Furthermore, the consistent presence of calcium oxalate in the analyzed stones corroborates the urine metabolic data, emphasizing a marked trend towards calcium oxalate supersaturation [ 4 , 13 , 43 ].

However, this was not observed when compared to the tumors treated with PBT+αPD1, despite a marked trend.

On the other hand, there was a marked trend among patients with low circulating CXCL14 levels to have worse outcomes (composite outcome and ACM) when compared with those with higher circulating CXCL14 levels ( Figure 5 and Table 3 ).

Of all the predictors in the selected models for both δ 13 C and δ 15 N, only population density and July average temperature showed a marked trend over the study period and are therefore driving some of the temporal trends in δ 13 C and δ 15 N. 4 DISCUSSION In this study, we sampled the serum of Svalbard reindeer between 1995 and 2012 to identify how the winter diets of a High Arctic herbivore have changed in response to long‐term climate trends and interannual variation, mostly depicted by the “normalization” of ROS events, increased summer temperatures and increased population density.

Introduction In the contemporary global landscape, there is a marked trend toward an aging population.

Between 2014 and 2017, rice of European origin showed a marked trend for certain pesticides that exceeded MRLs, such as in the case of isoprothiolane or carbendazim.

Compared with the 2010 measurement by Warner et al.,(2013)—when the water table stood at about 12.00 m 37 with a mean electrical conductivity of 2 376 μS/cm and mean TDS of 1 751 mg/L—the 2022 survey reveals a marked trend toward both drawdown and salinization: the average depth has increased to 19.39 m, mean EC has risen to 4 590 μS/cm (an increase of 93%), and mean TDS has climbed to 4.31 g/L (an increase of 146%).

Hence, control flies had a marked trend to end in positive optomotor positions, whereas SoxD-RNAi flies showed no preference (Fig. 5C ).