“a clear trend”

Interestingly, we did observe a divergent effect of infection complexity on the risk of severe malaria among children <5 years of age, who had a relatively negligible risk of severe disease with a more complex infection (≥3 identified haplotypes), compared to adults and children ≥5 years of age, who had a clear trend ( p = 0.07) towards a reduced risk of severe disease with more complex infections.

However, the authors found that beyond 1 month (OR 3.46 for abstinence in HE group compared with control), a growing number of patients in both groups relapsed, the overall significant differences between HE and control persisted until 6 months (OR 2.59) and retained a clear trend until 12 months (OR 1.66, p = 0.07) [48] .

Patients with ATTR-CA had similar LVEF but a clear trend for larger LV mass index (157.1±60.6 g/m 2 vs. 121.0±39.5 g/m 2 , p = 0.07) and a larger proportions of ATTR-CA patients had IVS thickness >13 mm (57.1% vs 13.1%, p = 0.02) as compared to HF patients with no ATTR-CA.

In this study, we observed a clear trend towards higher peroxynitrite production (+25%, p = 0.07).

However, there was a clear trend for mIPSC frequency to be greater in SSADH −/− mice compared to WTs (P = 0.07), that was reflected in the significantly different distribution of inter-IPSC intervals between genotypes (P<0.001) ( Fig. 2C ).

We did not find significant differences in the mRNA expression of PDHA1 or GCK in the islets of controls vs T2D donors, although we saw a clear trend of reduced GCK mRNA expression in T2D islets (p = 0.07) which agrees with previous findings regarding the reduced GCK mRNA in a larger cohort of T2D islets 30 .

Vascular surgery was performed in 12% in the historical cohort and 2% in the current technique cohort, which indicated a clear trend, albeit it did not reach significance ( p = 0.07).

Additionally, Cdkl5 +/− female mice showed a deficit in locomotor habituation during the 15 min of the open field testing session, with a clear trend toward improvement (p = 0.07) following GT treatment.

There was a clear trend evident that MitoGamide treatment impacted the prolongation of deceleration time observed in vehicle-treated Akita mice ( P = 0.07, Fig. 1e ).

Although there was a clear trend in the data, the difference was insignificant (p = 0.07; Student’s t-test).

All three genetic models amongst NIA (p≤ 0.04) and the dominant model of AFA (p< 0.01) reached the required statistical significance to confirm association with CAD., On the other hand dominant model amongst AA and allelic model amongst AFA could not reach the desired statistical significance but managed to show a clear trend of association with CAD (p = 0.07 for each).

In compatible, a clear trend of reduction in transition times normalised to the self-control ( P = 0.0708, Fig. 3 C) was observed in the UMB group (0.4574 ± 0.1173, n = 11) compared to that in the control group (0.8931 ± 0.1690, n = 9).

These responders demonstrated a clear trend toward longer OS compared with the non-responders (36.7 vs. 21.5 months, p = 0.071).

Consistent with our initial findings, BA59 again significantly ameliorated experimental disease and showed a clear trend toward overall clinical improvement (AUC = 30.73 ± 15.27, n = 22 vs. 38.95 ± 14.21, n = 22, p = 0.0713) (Fig. 3 B), whereas BA26 remained ineffective even at the higher dose (Figure S12).

While not reaching statistical significance, there was a clear trend towards reduced corneal opacity in all MSC treatment groups versus PBS-treated control mice (PBS v allo-MSC (D−1, D+1): p = 0.0717; PBS v allo-MSC (D−1): p = 0.0699; PBS v allo-MSC (D+1): p = 0.0641) (Fig. 2 b).

Differences in terms of overall survival between AML‐MRC ASXL1+ versus ASXL1− patients were found only in de novo AML‐MRC patients with intermediate‐risk karyotype (excluding MDS and MDS/MPN history and adverse‐risk karyotype), having ASXL1 + patients a worst outcome with a clear trend toward statistical association than ASXL1 −, HR = 2.9 P = .072 (Figure 3B ).

Regarding appropriate therapy, there was a clear trend toward statistical significance in both TTA and the Kaplan–Meier analysis, favouring the intervention group (log-rank P = 0.072) (Figure 2 ).

Similarly, the ITT analysis using the last observation carried forward method showed a clear trend towards greater mucosal recession in the CONVEX group compared to the CONCAVE group at the 3‐year follow‐up (OR: 4.8, 95% CI: 0.8–27.4, p = 0.072) (Table S2 ).

We also observed a clear trend towards longer PFS in patients with surgically free disease as compared to those with non-surgically free ( p <0.0721) ( Table 3 ).

Postoperative abdominal bulging occurred in six patients in total (9.7%): six patients (16.2%) in the control group and zero patients in the plication group, with a clear trend toward a statistically significant difference ( p = 0.0727) at comparative tests.

Though there was a clear trend for visual field defects in migraine patients, it failed to reach statistical significance (Fisher’s exact P value = 0.073).

In our study, patients treated with anti-CD20 showed a clear trend to increased risk of hospitalisation by COVID-19, which did not reach statistical significance probably due to sample size (OR 4.84, 95% CI 0.86 to 27.24, p=0.073).

For cardiovascular mortality, no single predictor reached P < .05; however, trials requiring NYHA III–IV at entry showed a clear trend towards higher CV death rates (β = +.064; P = .073; Δ R 2 = .143).

No change was detected concerning relational warmth but in regard to parent–child conflicts a clear trend was found, favoring the SPARE-condition with a group x time-effect close to significance (p = 0.073) and a significant within-group decrease of conflicts from baseline to 12-weeks follow-up.

Conducting the appropriate McNemar’s test with Edward’s continuity correction for paired nominal data to analyze the discordant pairs for both treatments demonstrates a significant change (worsening) in the use of laxatives from baseline to the end of treatment for OXN ( p =0.004) and a clear trend of improvement for TAP ( p =0.073).