“a clear trend”

Among male patients, two other factors presented a clear trend towards statistically significant effects ( p = 0.06) and deserve further attention.

In P8-9 animals, HFS overall induced a clear trend towards LTD (mean amplitude during last 10 minutes post-HFS recording vs baseline, p = 0.06).

While the difference in cholangitis was not significant in this analysis, there was a clear trend towards lower cholangitis rates in the PTBS group relative to the EBS group ( p = 0.06).

However, upon careful reading, the results of the Italian TSUNAMI RCT were not completely negative, but showed a clear trend towards efficacy ( p = 0.06) of CCP versus standard therapy in the subgroup of patients with milder (and thus earlier) disease.

There was a clear trend ( P = 0.06) toward a higher mean C rs (PEEP wave) of 6.8 ml/cmH 2 O in comparison to C rs (low-flow).

For example, the GVVT did show a medium effect size (η2 = 0.5) with a clear trend towards significance ( p = 0.06) when exploring differences between senior surgeons, residency surgeons and control subjects.

However, there was a clear trend for BEP to increase the level of H4K8ac in round spermatids (fourfold; P = 0.06) ( Fig. 1 A).

A clear trend was observed that BCC appeared in females in younger age compared to males ( p = 0.06) ( Table 1 ).

The analysis showed a clear trend towards increased protein levels GRP78 in neurons of the SNpc; the content of GRP78 increased 1.4 times ( p = 0.06) 3 h after its administration compared with the control ( Figure S4 ).

CCCP treatment indeed induced an increase in the number of autophagosomes in the three groups, and while there was a clear trend towards higher numbers of autophagosomes in hP301L‐expressing cells following CCCP treatment, there was no statistically significant interaction effect ( P = 0.06, Fig EV1 C).

Although a clear trend was apparent for alterations in SV by recovery condition, this did not reach significance ( p = 0.06).

In fecal samples, the median load was ~40,000 copies per ng total DNA in colonized mice without DSS, with a clear trend toward lower copy numbers in DSS-treated colonized mice ( p = 0.06) ( Figure 1 c).

Although it did not reach statistical significance, we could see a clear trend in decreased urotensin concentration in the athletes compared to the control subjects ( p -value = 0.06).

Moreover, comparison between groups showed a clear trend for Arc expression to be lower in Egr1 −/− than in WT mice ( p = 0.06), even if the level of ECS-induced expression in the dentate gyrus of WT mice represented only ∼5% of the initial increase observed at 30 min.

The small sample size together with severe illness in all patients at admission are probably responsible for such data; however, in acute renal failure there was a clear trend towards significance ( p = 0.06), as 2 (18%) and 11 (53%) patients had acute renal failure in survivor and nonsurvivor groups, respectively.

Although MYLK3 did not quite reach significance ( P =0.06), in the TCGA analysis there is a clear trend in the survival curves ( Figure 2A–C ) towards improved survival with increased methylation of MYLK3 in all data sets.

Only the specialized chest radiologist clearly approached the diagnostic performance of the CT model (p = 0.79), while a clear trend was seen for the other, less experienced observer (p = 0.06).

In contrast, FXS participants showed a clear trend towards a lower d’ on the 15° task compared with 90° or 45° tasks (p= 0.06).

Although not statistically significant, there was a clear trend developing toward a higher frequency of pulmonary infection in respiratory involvement subgroups ( p = 0.06) (Table 3 ).

Although a clear trend was observed ( P = 0.06), the difference did not reach statistical significance, presenting an apparent contradiction with the in vitro findings.

At the 22-h time point, a clear trend toward lower expression in the BpV-treated samples compared to control was also observed (0.24 ± 0.05 vs. 1.1 ± 0.28; P = 0.06).

Dunnett’s post hoc testing after ANOVA revealed a significant preventive effect for ectoine and a clear trend for NADA ( p = 0.06). 5-Hydroxyectoine had considerably smaller effects that did not prove to be statistically significant, probably due to the sample size of n = 10. 3.

Similarly, the ItchyQoLTM questionnaire revealed a clear trend of itch reduction after 6 weeks with 80% of subjects (12/15) noting decreased itch ( P = 0.06) which became significant after 12 weeks of bleach baths, with 100% of subjects noting improvements in itch (Fig. 1 e).

In our results, the decrease in the prevalence of insufficient PA was close to significance ( p = 0.06), but a clear trend was observed across all countries.

We found a clear trend between expression in brain and spinal cord in MS patients (p = 0.06, Additional file 1 : Figure S7).