We observed a highly significant nonlinear association of urinary 8-oxoGuo with serum ferritin ( P < 0.0001) and higher 8-oxoGuo concentrations for respirable iron >1,000 μg/m 3 compared to ≤57 μg/m 3 .
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However, there was a highly significant 20 fold increase (P = 0.0001) from 5 to 7 dpi (4,291±1,172 ng/ml).
The overall effect was highly significant ( Z = 9.00, p < 0.0001), confirming that elevated IAP is consistently associated with adverse clinical outcomes.
The size differences between the colonoids treated with tofacitinib and budesonide were highly significant ( P = 0.0001) for all donors at both 2 and 20% oxygen (Fig. 3 a-b).
Doxy-induction during differentiation led to a highly significant reduction of the relative amount of MAP2-positive neurons after 30 days in a dose-dependent manner (n = 3, Tukey's multiple comparisons test, p < 0.0001).
The combination of PZQ and ARA resulted in a highly significant ( P < 0.0001) increase in cure rates (78%) compared with 20% for PZQ alone but not egg reduction rates ( Table 1 ).
Results: There was a close correlation between the results obtained by both the techniques, with highly significant concordance ( P < 0.0001).
MVD was positively related to HIF-1α expression in BRCA1-2 carriers (r = 0.521, p = 0.006), and, in particular, we observed a highly significant correlation in the familial group (r = 0.421, p<0.0001).
The ability for these two themes to distinguish two groups within the data was further supported by the nonparametric multivariate inference test as it indicated a highly significant difference between those coding units coded with either theme (ANOVA test statistic = 13, df = 8, df2 = 927, p < 0.0001).
The highly significant differences in plasma progesterone levels between the follicular and premenstrual phases were equally strong for both groups (p < 0.0001).
Figure 4 shows a bar graph of the average A , ε m a x , ε ∞ , τ r of the 4 cell lines and indicates the level of significance: where p > 0.05 is not significant (ns), 0.01 < p < 0.05 is significant (*), 0.001 < p < 0.01 is very significant (**), 0.0001 < p < 0.001 is extremely significant (***) and p < 0.0001 is extremely significant (****), raw values can be found in Table S1 .
Pro; OR: 1.12, 95% CI: 0.90-1.75), a recent observational cohort study showed a highly significant association between the R72 variant (G allele) and PCa risk (OR: 7.937; 95% CI: 5.37-11.0, p<0.0001) in a Caucasian population, but no statistically significant enrichment of the R72 variant in patients with higher Gleason score disease (≥8) [ 29 , 30 ].
It is a nonparametric test that compares two unpaired sets of data significantly different when the p value is less than 0.05 (**** extremely significant P < 0.0001, *** extremely significant 0.0001 < P < 0.001, ** very significant 0.001 < P < 0.01, * significant 0.0.1 < P < 0.05 and ns not significant ≥ 0.05).
Together, these results depicted that the obtained linear model was highly significant ( p -value < 0.0001) and a lack of fit showed no significance ( p -value > 0.05).
When all datasets were combined, we found a highly significant association of younger age at diagnosis with increased CIN70 scores (p < 0.0001).
However, even if the strict Bonferroni correction had been applied for the 3 variables, all the relevant p -values would still have been highly significant as they are mostly p < 0.0001.
While no significant association was observed between ICANS severity and PFS, a direct and highly significant correlation between ICANS grade and OS was seen ( P < 0001, Fig. 1 C, D).
The interaction terms for birth year and area of residence (rural/urban) aged 10–12 years were highly significant for both men and women (p<0.0001).
This represents a highly significant overlap (odds ratio (OR) = 10.45, p < 0.0001, and OR = 18.74, p < 0.0001, respectively; Figure 2 ) which could explain some of the synergistic/additive effects of LMP1 and LMP2A observed in mouse B cells described above.
A concomitant positivity of NPT and nasal IgE test to Alternaria was observed in about 70% of patients, while positivity of SPT and NPT was observed in 27% of patients, this difference being highly significant (p < 0.0001).
There was a highly significant concordance between the counts obtained by the HHAC and those by microscopy for mf densities of >5,000 (p<0.0001, r c = 0.97) or >30,000 per ml (p<0.0001, r c = 0.90).
The log-rank test indicated a highly significant difference ( p < 0.0001) when the PrC-210 survival curves were compared to their respective vehicle-treated groups (i.e., fasted or fed).
This analysis revealed that samples of genotype SBb display significantly lower relative amounts of SiOR89 (by 50%) and marginally significant for SiOR88 (by 37%), as compared with SBB samples from either monogyne or polygyne colonies ( fig. 1 c ; P < 0.0001 and P = 0.07, respectively, Tukey post hoc tests following a mixed effects model analysis).
In contrast, the regression was significant (ANOVA: F 1,198 = 113.3754, P< 0.0001) but the Lack-of-Fit was also highly significant (ANOVA: F 8,190 = 22.9589, P< 0.0001) for the Explicit-Shaping bees over the entire set of covered trials (trials 11–20).
Both the environmental variation and G × E interaction were highly significant ( P < 0.0001) (Additional file 2 ).