Excerpts

Statistical findings reinforced this approach: A one-way ANOVA on mean percent change in Cp showed a strong group effect [F(2,36) = 50.42, p < 0.0001)], with post hoc Tukey HSD tests revealing no significant difference between Non-Responders and Placebo (mean difference = 0.25%, p = 0.998), but large, highly significant differences between Responders and Placebo (mean difference = 35.74%, p < 0.0001) and Responders and Non-Responders (mean difference = 35.49%, p < 0.0001).

Statistical analysis confirmed the highly significant superiority of CINPs (∗∗∗∗ p < 0.0001).

The regression model of PHWE-PTXP yield was extremely significant ( P < 0.0001), the correlation coefficient ( R 2 ) was 0.9696 and the lack of fit had no significant effect ( P > 0.05).

Tests for interaction with time and birth cohort were highly significant (p values<0.0001), both in models where birth cohorts were included as indicator variables and as one ordinal variable, indicating that the decrease in total cholesterol became significantly steeper the older the birth cohort.

Two-way ANOVA showed highly significant effects of treatment, cell death state, and their interaction (F (15,48) = 1810.36, p < 0.0001), confirming that treatment-dependent differences varied strongly across states.

For the five oceans under investigation a significant trend was found (p<0.0001, significance level of 0.05).

There was a highly significant effect of suggestion ( F 2,312 = 585.8; p < .0001), a marginally significant effect of hypnosis ( F 1,312 = 3.6; p = .060) and no significant effect of group ( F 1,312 = 2.6; p = .11).

The overall multivariate log-rank test was highly significant (chi-squared = 71.16, p < 0.0001), confirming significant differences in conversion-free survival across dose groups.

The analysis revealed a highly significant main effect of binarization method (F(1.776, 115.4) = 1689, p < 0.0001).

The overall effect of the model was highly significant ( p < 0.0001), indicating that NH 4 + , K + , NO 3 − , BAP, and NAA significantly affected growth.

The analysis revealed highly significant effects ( p < 0.0001) for environment, replicates within environments, lines (genotypes), and the genotype-by-environment interaction.

MVD was positively related to HIF-1α expression in BRCA1-2 carriers (r = 0.521, p = 0.006), and, in particular, we observed a highly significant correlation in the familial group (r = 0.421, p<0.0001).

The ANOVA analysis shows that there is a highly significant influence of the coffee variety ( p < 0.0001) and the raw material ( p < 0.0001) on methanol concentration.

Both the model based on Ad26.COV2.S and the model based on all vaccine candidates have highly significant slopes ( p < 0.0001) in the nose.

The analysis of extracts spiked with known concentrations of the compound ( Figure 3 c) showed a highly significant correlation between P5C concentration in samples and its estimation ( p < 0.0001 in a Pearson two-tailed test) and allowed us to evaluate the recovery (about 85%) and to estimate the detection limit of the method (about 20–30 nmol g −1 FW under the experimental condition used).

The diminution seen was highly significant ( p < 0.0001) as determined by paired Wilcoxon signed-rank sum test.

P values were represented as asterisks; p values of <0.05 were considered statistically significant: 0.01–0.05, significant (*); 0.01–0.001, very significant (**); 0.001–0.0001, highly significant (***); p<0.0001, extremely significant (****).

Assessment of daily compliance by MEMS The difference in the percentage of days with the correct number of doses taken between the groups was highly significant in favor of the betaxolol group (84.4% vs 64.0%, p < 0.0001).

Both groups showed highly significant intra-group improvement from preoperative values (paired t-test, p<0.0001).

The difference between the microbiome profiles of these groups was highly significant ( p = 0.0001, F = 13.75) ( Fig 5B ).

This quantitative analysis revealed highly significant overall differences between groups and sample areas (Group: F (1,40) = 38.89; p < 0.0001; Area: F (3,40) = 7.9; p = 0.0003; Interaction: F (3,40) = 3.2; p = 0.0332).

A statistically highly significant correlation was found between changes in 99m Tc-Annexin V tumor uptake and clinical response (r 2 = 0.62; P < 0.0001).

There was a small (median differences = 0.01-0.04) but highly significant increase of DNA methylation in females compared to males in FBXL5 and CACYBP (p < 1.00E-04) and a trend towards significance for SCMH1 (p = 0.07), in the diabetes study where samples of both sexes were included [ 27 ] (Figure 6 ).

Overall, there was a small, but highly significant relationship between genetic and geographic distance (Spearman correlation coefficient ρ = 0.226, p <0.0001).

There were highly significant differences ( P < 0.0001) among all groups regarding almost all postoperative ocular aberration components.