Excerpts

The results indicated that the pericarp browning index showed an extremely significant positive correlation with the expression of LOX2 (r = 0.95, p -value = 2.58 × 10 −5 ) and rotting rate (r = 0.95, p -value = 3.79 × 10 −5 ) and a high positive correlation with the MDA content (r = 0.92, p -value = 1.58 × 10 −4 ), GR activity (r = 0.91, p -value = 2.51 × 10 −4 ), the expression of PAL1 (r = 0.85, p -value = 1.80 × 10 −3 ), JAZ (r = 0.84, p -value = 2.47 × 10 −3 ) and PR-1 (r = 0.81, p -value = 4.23 × 10 −3 ).

The main effects of qDH3 , qDH6 , and qDH7 were highly significant (3.8 × 10 −15 < p < 2.6 × 10 −5 ) in both 2016 and 2017.

As expected, the LAMP analysis revealed highly significant evidences for both linkage (LOD = 5.19, p = 2.6×10 −5 ) and association (LOD = 45.88, p = 7.2×10 −48 ), and both the evidences are mapped to the HLA-Cw6 locus.

The correlation with OS was highly significant: HR = 2.2 (1.51–3.21) with 95% CI (log-rank p -value = 2.6E−05).

Pentapeptide-sharing was found to be highly significant between schizophrenia-related proteins and the hemagglutinin precursor (χ2 (1) = 17.723, p = .000026, two-sided).

3e ) the slope of the regression line was highly significant (F 1,1082 = 17.83, r = 0.179, p = 2.6 × 10 −5 ), as was the increase of the post-training slope relative to the pre-training one (F-test, F 1,2288 = 15.31, p = 0.0001).

14 , a SNP at the PIDD1 gene locus reached suggestive significance 14 ( P = 7 × 10 −7 ), and our lead novel variants at SSBP3 and THSD7A were at least nominally significant ( P = 2.61 × 10 −5 and P = 0.025, respectively).

Its first component was found to have a highly significant correlation ( r = 0.77, p = 2.62 * 10 −5 ), as well as a steep relationship to PMA (slope a = 0.88), suggesting that global properties of the connectivity might also reveal robust developmental correlations.

The inter-annual variability of CO 2 fluxes We found the increasing net carbon uptake was most likely driven primarily by a positive trend seen in the photosynthesis ( Fig. 3 a; and 6 a (R 2 adj = 0.97, p value= 2.62e-05)) and a stable R h ( Fig. 3 b).

Of all 1540 possible gene pairs, we found that a total of 226 pairs were significantly enriched beyond what would be expected by chance (hypergeometric test, Benjamini-Hochberg–adjusted, P < 0.05), with highly significant pairs such as Cdkn2a + Pten (co-occurrence rate = 7/10 = 70%; hypergeometric test, P = 2.63 × 10 −5 ), Cdkn2a + Rasa1 (co-occurrence rate = 6/9 = 67%; P = 7.96 × 10 −5 ), Arid2 + Cdkn1b (co-occurrence rate = 11/17 = 65%; P = 9.13 × 10 −5 ), and B2m + Kansl1 (co-occurrence rate = 11/18 = 61%; P = 3.6 × 10 −4 ; Fig. 5 , B and C, and table S13).

In contrast, a higher minor allele frequency (15.6%) of the p.Leu1007fsX1008 (rs2066847) frameshift mutation was seen in patients with aggressive disease, compared to 8.2% in patients with mild disease which was highly significant (p = 2.63x10 -5 , Table 2 ).

Highly significant differences in plant growth (PRA29) were observed when flm-3 was complemented by either of the QTL alleles ( p = 2.638e−05).

The correlation between ALDH5A1 and beta-alanine was highly significant ( r = –0.24; p = 2.7 × 10 -5 ).

Chloramphenicol resistance has been observed in other isolates in this setting to decrease, and in line with this we observed 41/195 (21%) isolates resistant to chloramphenicol with a decreasing trend, from 2/7 (28.6%) in 2012 to 3/39 (7.7%) in 2020 (−30.5% change per year; p = 0.000027; Fig. 5d ).

As shown in Fig 5 , a highly significant correlation between LV active force σ and the Seattle 5-year score was found (R = 0.77, p = 2.7x10 -5 ).

Methods Ligand binding site similarity between COMT and InhA Previously, the SOIPPA algorithm had revealed a highly significant similarity (p-value = 2.7e-5) between the NAD binding site of the Rossmann fold and SAM binding site of the SAM methyltransferases [11] .

The idh2 ∆ single mutant was 2.5-fold more resistant to fluconazole (IC50 = 59.4 ± 1.1 μg/mL) than wild-type BG14 (IC50 = 24.1 ± 0.9 μg/mL) and the difference was highly significant ( P = 2.8E-5, n = 3, Student’s t -test).

NPA difference in peak ChBF increase with NTS stimulation was highly significant ( p = 0.028 × 10 3 ; Figures 6 , 8 ).

The tumor-subtype and stage-dependent expression of JUN was highly significant when comparing healthy and primary ( p = 2.8e-05), primary and metastatic CRPC ( p = 2.6e-43) and primary and metastatic NEPC ( p = 5.3e-04) (Supplementary Fig. 1g), suggesting JUN as a potential marker of progressive subtypes of PCa.

A highly significant relationship was observed between the RS and the likelihood of DM whether the RS was treated as a continuous (Wald test; HR = 2.76, Scaled HR; 5.65; p = 2.8 × 10 −5 ), or a binary (log-rank test: HR = 8.25; p = 8.0 × 10 −4 ) variable (Figure 1A ).

However, at 35 °C, all three segments had highly significant effects (one-way ANOVAs, p values ≤ 2.8 × 10 −5 ; Fig. 2f ).

Yet our GRS that was based on known European and Asian POAG SNPs showed a significant trend ( P = 2.81 × 10 −5 ) and a twofold increase in POAG risk comparing extreme risk groups.

hsCRP For hsCRP, strong association signals were detected in the previously described CRP gene (rs1205, p = 8.20×10 −30 ) and in the 3′ of APOC-I ( Apolipoprotein C-I ) gene (rs4420638, p = 7.12×10 −11 ) ( Figure 3C and 3D and Table 2 ), a well known determinant of serum hsCRP that did not reach statistical significance (p = 2.85×10 −5 ) in our initial scan (Stage 1) [25] .

Consistently, a drop in dispersion test showed a highly significant decrease of dispersion upon incorporation of mean intraoperative dBP, liquid balance of length of surgery into the regression formula (F statistic 8.3912, p = 0.000028737), while the addition of mean intraoperative MAP had no further significant effect (F statistic 2.989612, p = 0.085425).

Histopathological findings across MVI cohort A highly significant association was observed between microvascular inflammation and C4d positivity (p=0.000029).