Excerpts

The difference between the cumulative growth in the number of PVCs in the control and riluzole groups was highly significant, at p<0.00002.

In agreement, t tests between viruses exhibiting high or low transmission and titers from NW specimens generally did not reach statistical significance in RDT experiments, but did in DCT experiments, notably for mean peak NW titer (RS-p = 2.05e-5, with mean titers of 5.76 and 6.93 log 10 EID 50 /ml for viruses exhibiting ≤50% or >50% transmissibility in a DCT setting, respectively) (Fig. 2A–C , Supplementary Table 2 ).

The bin spanning R 2 = 0.98–1.00 — centered on Rc—exhibits a highly significant dip test (p = 2.1 × 10 −5 ; GMM-BIC: two components), directly capturing the symmetry-breaking transition at the bifurcation point.

The difference between stimuli remained highly significant ( F (1,43) = 23.69, p = 2·10 −5 , η 2 = 0.137, η p 2 = 0.355), in accordance with vestibular enhancement.

One SNP (GGaluGA348872), located at 1.87 Mb on GGZ, had highly significant association with IMF Br (p = 2.14 × 10 -5 ) and is located 122.3 Kb upstream of the kinesin heavy chain member 2A ( KIF2A ) gene.

This enrichment of previously described vaccine candidates in our Vacceed set was highly significant (one-tailed Fisher’s Exact Test – P = 2.2 × 10 −5 ).

In this model (adjusted R 2 = 0.73), sample size had no significant effect on α ( β = −1.2e-04, p -value = 0.48), whereas IGRs showed a highly significant positive shift ( β = 0.137, p -value = 2.2e-05).

Post-Hoc analysis by Pairwise T-Test with Bonferroni-adjustment showed that there was a highly significant reduction in the ABZ and ABZ/BTZ-treated group as compared to the control (p = 2.2e-05 and p = 1.3e-06, Figure 8B ).

A highly significant ( p = 2.2 × 10 −5 ) OPLS model could be built for the classification of samples by production year (model 8).

A role for cis -regulatory elements in methylation fidelity was also demonstrated by highly significant (p<2.2×10 −5 ) enrichment of transcription factor binding sites in CGI probe loci showing heritably high (118 elements) and low (47 elements) methylation, and also in loci demonstrating stochastic hyper-(30 elements) and hypo-(31 elements) methylation.

This SNP remained highly significant upon conditioning on the previous RA risk variant (rs394581, P =2.2 × 10 −5 ) or on a SNP previously associated with celiac disease and type I diabetes (rs1738074, P =1.7 × 10 −4 ).

Even though sample sizes in the East Asian cohorts are small, we observed that 62% of the signals have supportive evidence in East Asian ancestry-only analysis, with the same direction of effect, and 20% of these signals are also nominally significant (binomial test p = 2.27 × 10 −5 , 95% confidence interval [CI] = 7%–100%) ( STAR Methods ).

While One‐way ANOVA tests indicated minor statistical variations among the samples within the same channel (p = 0.0132 for the 1.0 mm channel; p = 0.0035 for the 1.6 mm channel), these maximum deviations (∼0.27 mm/s) were negligible compared to the highly significant performance shifts induced by variations in the environmental geometry (an absolute speed difference ranging from 1.8 to 2.3 mm/s, p = 2.27 × 10 −5 when comparing the pooled sample data between the two channels).

Expression of GABA-related genes positively correlates with viral load The effect of DWV load on GABA-related gene expression was highly significant in GR bees (GLM, MB DWV log 10 ; β est.=0.473, s.e.=0.108; t =4.365, P =2.28×10 −5 ) while this was not the case for BR bees (GLM, DWVlog 10 ; β est.=−0.248, s.e.=0.134; t =−1.849, P =0.067).

Chlorophyll a is also showing an increasing trend over time (slope = 0.12, P = 0.000023).

For CS- tones, a highly significant increase in SSA occurred after conditioning ( Fig 4F , 16%, F(1,1801) = 18, P = 2.3*10 −5 ).

We employed standard ANOVA F-tests [ 59 ] to evaluate the significance of the interaction term (reflecting varying slope by treatment group) and found that the evidence did not support inclusion of the interaction term (P = 0.93) when comparing these two models, but when comparing the simpler model to the trivial model that ignores treatment group (adjusted R 2 = 0.75), the ANOVA F-test P-value is highly significant (P = 2.3e -5 ), supporting the inclusion of group-specific intercepts, but not group-specific slopes, in the final model.

We observed highly significant effects in men (effect size or ES=(M TLS −M MLS )/SD pooled =1.15, p=2.3×10 −5 ) and women (ES=1.25, p=8.2×10 −4 ) in the expected direction corresponding to a three times higher consumption of game intake in those with a traditional lifestyle.

When testing the same networks with the top 900 and 850 strongest connections retained, E glob remained highly significant ( p = 2.31 × 10 −5 for 900 and p = 3.07 × 10 −5 for 850 links).

This increase of GSH plasma concentration was highly significant already after 1 h of preparation delay (paired Student’s t -test p -value = 2.34 × 10 −5 , Figure 1 A, left panel).

Nevertheless, the correlation between genetic diversity and geographic distance from Asia remained highly significant after controlling for the number of infections [generalized linear models (GLM), P < 2.37 × 10 −5 ].

The analysis demonstrated a highly significant increased effect size when stimulation was applied to subcortical strokes versus the mixed strokes ( p = 2.45598e−05, two-tailed Mann–Whitney U -test.) When sub-analyzed within the context of type of stimulation technique, this significant finding was reproducible for both rTMS and tDCS articles (rTMS p = 0.01115294 and tDCS p = 0.01428572, Mann–Whitney two-tailed U -test).

The log-rank test showed a highly significant difference in MFS between patients with low (⩽0.81, n =62, 26.6%) and high (>0.81, n =171, 73.4%) ATM protein levels ( P =0.000025; Figure 1B ).

The coastal southern part of Cameroon had the lowest Bd burden with a highly significant decrease of cases over time (odds = 0.4, P -value = 2.5 × 10 –5 , Table 1 ).

A linear model of incidence by commune on both IDH and Amerindian ancestry showed that HDI remained highly significant (p < 2.55e−05).