Excerpts

When the imbalances observed in our samples at the SNPs rs6983267 , rs961253 , rs3802842 , rs10411210 , rs4444235 , rs4779584 , and rs9929218 were combined with those published previously [19] , [35] , we observed a highly significant relative loss of the non-risk T allele of rs6983267 (p-value = 2.94×10 −5 ).

However, the KNN classifier trained on the exonic subset of features showed no statistically significant difference in BCR-free survival using a log-rank test ( p < 0.08) whereas the difference was highly significant for the non-exonic KNN classifier ( p < 0.00003).

Compared with population data, enrichment of SIX1 loss-of-function variants was highly significant (p=0.00003).

In particular, CM-CF showed highly significant differences compared with U-CF ( P value = 0.00003), indicating a positive effect of the combination of mercerization and coating on CF stiffness.

Three significant loci were identified by this analysis ( P < 0.000002), along with a fourth marginally significant ( P < 0.00003).

This difference is highly significant ( P = 0.00003), calculated using a χ 2 test. 10 Financial disclosures are summarized in Table 1 .

Nonetheless, the difference in tumor growth between +dox and -dox was highly significant ( p = 0.00003).

FI was the most highly significant factor between patient groups with a good and poor outcome ( P =0.00003, independent groups t -test, t =−4.38, df 98).

Symptom prevalence The most frequently reported symptom among patients with uterine isthmocele was AUB, observed in 45 cases (78%), which showed a highly significant association (p = 0.00003).

Compared to the untreated control, both treatment protocols resulted in a highly significant reduction in viable cell counts (t-test, t (5) = 14.30, p = 0.00003, ***), corresponding to a ~ 4 log10 reduction (Figs. 6 and 7 ).

Furthermore, we also confirmed there was a highly significant correlation between MM and GS in this module (Cor = 0.47, p =3 e − 05) ( Figure 3(d) ).

When we compare SO 2 values with HbO 2 double peaks the difference was highly significant ( P = 0.00003).

We reported co-occurring mutations in TP53 and PTEN , and in PIK3CA and TP53 , and a highly significant enrichment for trios of co-occurring mutations in TP53, PIK3CA , and PTEN (n = 3/30; P = .00003) as compared with TCGA (The Cancer Genome Atlas) breast cancer exome sequence data.

Regarding the comparison of IGRA results in disseminated versus other forms of tuberculosis, a previous multicenter study using data from collaborators from mainly high-income European countries found that in children with microbiologically confirmed tuberculosis IGRA sensitivity, when results were pooled for different versions of IGRAs ,was 70% (56/79) in those with disseminated versus 89% (283/315) in those with pulmonary tuberculosis, which we calculated was a statistically highly significant difference ( p = 0.00003).

In all cases, there was a clear bias of propagation in one orientation, which was highly significant ( P < 3 * 10 −5 ; 12 retinas aged P4–6; data not illustrated).

Consistent with this, regression of second component dopamine responses to cues (0.2–0.6 s after the cue onset) onto value estimates of the superior model was highly significant ( Figure 4B , right, R 2 = 0.93, p=0.00003).

The dust sheet test 2–3 h showed the highest correlation with the reference method with the data points scattered closely around the regression line and the slope being highly significant ( p = 0.00003).

For the multitalker babble noise (20T), we find that with the exception of SCNR all intelligibility improvements caused by the schemes compared with NoPre are highly significant ( p < .00003).

This highly significant enrichment of S-aromatic motifs within the low-reactivity group (p-value = 3 × 10 −5 ), allows us to conclude that the involved methionines exhibit a much lower reactivity than their non-interacting counterparts.

Highly significant differences were seen in plasmacytoid DCs (pDCs) (mock primed: 56.4±1.6; ArmΔGPC primed: 30.2±1.7, p = 0.00003), macrophages/monocytes (mock primed: 11.4±1.6; ArmΔGPC primed: 2.1±0.6, p = 0.0017) and FRCs (mock primed: 9.0±0.4; ArmΔGPC primed: 1.7±0.3, p = 0.000007) from primed and mock primed Cl13 infected mice ( Fig. 6A ).

Under this null model, there was a highly significant increase in the proportion of missense mutations on the ligand-binding interface (Fig. 3e , expected = 43%, observed = 64%, p = 3e −5 , n = 107, two-tailed binomial test, Supplementary Note 10 ).

Association analysis in Hanoverian stallions In 216 Hanoverian stallions, a nominally significant association with de-regressed EBV-PAT was found for the NOTCH1 variant g.37455302G>A ( P = 0.00003) using a model fitting the genotypes.

The difference in the GPi cell firing frequency across the groups was highly significant ( figure 2 C p=0.00003).

filters F3+F4; 365 SNPs in 396) (Table 3 ), a highly significant difference was found in the final number of SNPs recovered with call rates ≥ 95%, (Chi-square Pearson = 17.40; p = 0.00003).

There were highly significant differences between the mean PRS in affected women at baseline compared to unaffected women in each cohort as well as the combined set (p=3x10 −5 , 1x10 −6 , and1x10 −10 , respectively).