Excerpts

Because of the large number of samples, the comparisons gave highly significant results, typically with p < 0.00001 after Bonferroni correction. 2.6.4 Simple and complex extensions of spectral statistical parametric mapping (sSPM) In our more recent studies' we have standardized the frequency domain analysis.

An unpaired Student's t -test demonstrated that both combination treatments were significantly different to the appropriate controls, which resulted in an overall highly significant one-way ANOVA test ( P <0.00001).

The patient is assigned the high or low risk of relapse category if the score is ⩾2.41 or <2.41, respectively, with highly significant differences in RFS ( P <10 −5 ) and OS ( P <10 −5 ) between both groups.

Comparing the proportion of stage I PDACs to the national average is highly significant; in 2016, 5.4% of 8,398 PDACs in the SEER database (National Cancer Institute-SEER) were stage I by surgical pathology ( P < .00001, Fisher's exact test). 3 Seven of the nine patients diagnosed with a screen-detected PDAC are alive, with median overall survival to date of 3.84 years.

Given the small sample size, nominally significant CpG-smoking associations were defined as having P < 1x10 −5 and were displayed using a ggplot2 boxplot.

When the blind evaluator rated photos, there was a slightly smaller but still highly significant decrease in score (−1.1) from day 0 to day 360, t(36) = −10.712, p < .00001] with no significant decrease in effect from day 60 to day 360 in most patients as can be shown in Figures 2 – 4 below, with the minority of patients having minimal regression, Figures 5 – 7 .

In the second International Study of Infarct Survival (ISIS-2) in patients with ST segment elevation myocardial infarction (STEMI), the use of aspirin as opposed to placebo was associated with a highly significant reduction in vascular mortality (9.4% versus 11.8%, P < 0.00001) along with significant reduction in rates of reinfarction (1.0% versus 2.0%) and nonfatal stroke (0.3% versus 0.6%) at five weeks. 6 Blockade of the P2Y 12 subtype of adenosine diphosphate (ADP) receptor on platelet cell membranes ( Figure 1 ) has been established as another key mechanism of platelet inhibition.

The STRING (Search Tool for the Retrieval of Interacting Genes/proteins) functional analysis of DAPs during the 8–12 cell-to-morula transition confirmed the highly significant enrichment in the ribosome, spliceosome and RNA transport pathways (p-values < 10 −5 ; see all enriched terms during the 8–12 cell-to-morula transition in Supplementary Table S5 ).

All eligible cases (1,300 cases) Univariate analysis of all cases with complete Mammostrat ® data irrespective of ER status, nodal status or treatment showed a highly significant association between Mammostrat ® score and DRFS (Figure 2b ), between score and RFS (Figure S1D in Additional file 1 ), and between score and OS (all P < 0.00001; Figure S2D in Additional file 1 ).

Logistic regression testing the effect of sequence length on whether or not the query sequence have at least one BlastX hit ( E value 10 -5 ) was highly significant (p-value < 0.00001).

Three studies ( n = 218) evaluated ADAS-Cog as an outcome of hyperbaric oxygen intervention, with considerably significant results for the pooled analysis [MD = −4.53, 95%CI (−5.05, −4.00), I 2 = 50%, p < 0.00001; Figure 3B ].

Highly significant differences were observed between susceptible and resistant UTI groups ( p = 0.00001 and p = 0.000015, respectively), indicating BCG cycles as a key differentiating factor.

With 10, 000 random permutation test, we confirmed such an enrichment of genes with higher expression variability in YRI is highly significant (P<10 −5 ).

Quantitative assays determined using DNS revealed highly significant differences ( P < 0.00001 with Tukey's HSD at 5 %) for cellulolytic activity among the assayed gut bacterial isolates.

Notably, the overall relationship between FM and LBM was positive and highly significant ( r = 0.59; P = 0.00001).

Genome-wide significance was the accepted P < 5 × 10 −8 while marginal significance was P < 1 × 10 −5 .

A highly significant correlation (R 2 = 0.9021, p value < 10E-6) was calculated between the two techniques (Figure 7 ).

Two of these SNPs, rs7948623, rs11230664, are also genome-wide significant GWAS SNPs for pigmentation variation in Africans, while the third, rs3741265, is marginally significant ( p < 10 −5 , Fig. 5 ).

In DHLF-COPD the Mann-Whitney U test showed a highly significant difference in distributions (U = 41246, p = 1.01 × 10 −5 ) and Mood’s Median Test confirmed a significant difference in medians (χ 2 = 15.82, p = 7 × 10 −5 ) comparing control and treatment group while in NHLF no significant correlation could be detected (Fig. 6 A).

The correlation between the ranking of amino acids of Figure 4 A and the one in Figure 5 E was highly significant (ρ = 0.81; p = 1.03 × 10 −5 ), despite the limited number of epitopes with available X-ray structures used to estimate amino acid frequencies in Figure 5 E.

Here, an equivalent time point comparison at 15 min revealed that CBD invoked a highly significant negative shift in Va from a baseline value in control recordings of Kv7.2 wt + Kv7.3 of −29.8 ± 1.25 mV to −35.6 ± 1.36 mV (n = 8; p = 1.06 × 10 −5 ) in CBD ( Figure 5 A).

The OPLS-DA model showed a good fit (R 2 = 0.65), predictivity (Q 2 = 0.55) and a highly significant CV-ANOVA ( p value = 1.1E −5 ).

We mapped the regional presentation score of the most highly represented protein in the neuroblastoma ligandome, NPY (29 MHC Class I peptides detected in 16 neuroblastomas), finding a highly significant concordance between the empirically detected peptides and those regions of the protein expected to be highly presented ( Figure 3E ; p = 0.000011), and find no peptides in the ligandome derived from the signal peptide region (aa 1–28) which is cleaved from the full-length pro-NPY protein.

6 , 7 were significant in our results (Bonferroni corrected p <5.61x10 -6 ), while BSN just missed significance ( p =1.10 x10 -5 ).

Additionally, the Arg460Gly variant independently showed a moderately significant protective association with the heavy smoker phenotype (OR = 0.56; CI = 0.43–0.72; P = 1.1 × 10 −5 ).