Excerpts

To lend further support to the relationship between hepatic inflammation and TG levels in the liver, there were highly significant positive correlations between hepatic TG levels and TNFα (P < 0.00001), MCP1 (P = 0.0001), IL6 (P < 0.001) and IL1β (P < 0.00001) protein levels.

3.2 Response to ETI therapy initiation Effects of ETI therapy assessed with averaged CFAbd-day2day © responses revealed a highly significant decrease in the median total score ( p = 0.00001).

The highly significant P-value (P < 0.00001) in our study suggests a non-random occurrence, further emphasizing the condition’s strong presence in the population under investigation.

Age showed a trend for association with individuals with both diseases (p = 0.00001; OR = 3.6, 95% C.I. 0.9-10.7) and chronic periodontitis alone (p = 0.002; OR = 3.0; 95% C.I. 0.8-10.52), suggesting that the difference in the distribution of BRINP3 alleles between healthy and individuals affected by peri-implantitis is confounded by the difference in the age of both groups (healthy individuals were on average 8 years younger than the affected individuals; Table 1 ).

For example, witnessing violence toward siblings on the MACE showed a highly significant association with DES scores (β = 2.02, t = 4.75 p < 10 -5 ), whereas witnessing interparental violence did not (β = 0.60, t = 1.44, p = 0.15) and experiencing physical abuse had only a marginal association (β = 0.85, t = 1.83, p < 0.07).

After purification procedures and molecular analyses, the biological activity of this recombinant glucagon was examined using in vivo assays and showed a highly significant (p < 0.00001) and prolonged effect on glucose levels when compared with the standard glucagon.

Future habitat suitability variation Pearson’s correlation coefficients between the habitat suitability maps generated for the different timeframes (2041-2060 and 2061-2080) and future climate scenarios were all higher than 0.999 for the ALP models and between 0.991 and 0.999 for APE; all the correlations were highly significant after Dutilleul's correction for spatial autocorrelation (p < 1×10 −5 ).

This difference in means is highly significant ( P <0.00001).

This superiority of RBZ and RBZ + Laser compared to laser treatment in terms of a positive effect on BCVA were highly significant (WMD = 5.65, 95% CI, 4.44–6.87, P<0.00001 and WMD = 5.02, 95% CI, 3.83–6.20, P<0.00001, respectively), with no heterogeneity identified ( Fig. 2A and 2B ).

A highly significant positive correlation was found between the weight of male newborns and their mother’s weight ( r = 0.389; P = 0.00001), while no significant correlation ( r = 0.180; P = 0.0871) was found between the weight of female newborns and the weight of their mothers (Figure 1 ).

Correlation analysis across six independent bulk transcriptomic cohorts (TCGA-PAAD, ICGC-PAAD-CAseq, GSE85916 , GSE79668 , GSE71729 , and EMTAB6134) demonstrated a highly significant positive association between THBS2+ CAF signature scores and T-cell exclusion scores (all p < 1 × 10−5), indicating that tumors with high THBS2+ CAF infiltration exhibit restricted T cell access to tumor nests ( Fig. 4 B).

To confirm that the reported effects are not isolated and support the structure of the comparisons shown, we ran Friedman tests as non‐parametric omnibus tests which yielded highly significant results (alpha band, p < 0.00001 , χ 2 = 115.93 , Kendall's W = 0.68 ; gamma band p < 0.00001 , χ 2 = 120.6 , Kendall's W = 0.7 ).

Highly significant inter-study heterogeneity was noted (I 2 = 85%; χ2 p= 0.00001).

These models showed that indeed there are highly significant differences ( p < 0.00001) in infection rates between some populations for all three pathogens tested ( Data S2 ).

For sedentary individuals, the results show highly significant differences between the four conditions [ χ ( 3 ) 2 = 25.15, p = 0.00001].

There is a highly significant correlation of the expression levels of individual ta-TRIM s as determined from EST and from RNA-Seq data (Pearson correlation test, P < 0.00001), confirming that the variation observed among ta-TRIM s is not an artifact of the mapping algorithm or the selected parameters.

But the actual percentage of double-positive bipartite synapses was much lower, only 4.8 ± 1.8%, and the difference was highly significant (p < 10 -5 , two-tailed t -test).

2011 ), which is highly significant (permutation P < 1 × 10 −5 ) ( Fig. 3 B).

While the difference in colony size ratio between 0 and 125 μM EDTA for PY79 is significant by a two-tail t -test ( p < 0.02), the difference between these concentrations for σD ::tet is highly significant ( p < 0.00001).

We found a highly significant ( P <1e−5 through a permutation test) correlation between model predictions and high-throughput data ( Figure 4B ; see Supplementary information ).

There was no significant difference in MM96L when siNF1 was compared with miR-514a, whereas in MM253, particularly at higher drug dosage (10-100nM), the differences between siNF1 and miR-514a, were highly significant ( p < 0.00001) (Figure 5a ), indicating that the mode of BRAFi resistance was different, possibly due to other targeted genes of miR-514a.

In both residue-level and protein-level assessments the improvement in performance of aaRNA over the alternative methods was highly significant ( P -values <10 −5 and <10 −10 , respectively).

When 29 studies containing 4,390 patients who had received radical surgery (I–III) were considered, highly significant heterogeneity was detected ( χ 2 =92.48, P <0.00001; I 2 =70%).

The power of the TCI to predict the membership of individuals in a particular rsFC group (i.e., squared multiple regression R 2 ) was strong and highly significant for group 1 (R 2 = 52%, F = 79.42, p < 1E−5, RMSE 0.11), group 3 (R 2 = 67%, F = 142.9, p < 1E−5, RMSE = 0.07), group 4 (R 2 = 35%, f = 51.2, p < 1E−5, RMSE 0.17), and group 5 (R 2 = 46%, F = 7 l.9, p < 1E−5, RMSE 0.14).

Loci harboring marginally significant evidence for association at P <10 −5 were examined for independent signals via regression analyses in PLINK. 16 A term was added to the regression model including the lead SNP as a covariate, and SNPs within the same candidate gene, or ±200 kb if the candidate gene region was <200 kb, were evaluated for maintaining array-wide significance.