Additionally, the Arg460Gly variant independently showed a moderately significant protective association with the heavy smoker phenotype (OR = 0.56; CI = 0.43–0.72; P = 1.1 × 10 −5 ).
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The OPLS-DA model showed a good fit (R 2 = 0.65), predictivity (Q 2 = 0.55) and a highly significant CV-ANOVA ( p value = 1.1E −5 ).
The Wilcoxon rank-sum pairwise tests confirmed this trend within light settings: the differences between paired control and positive-trained groups were highly significant in all light conditions (G: Z = 4.395, p = 1.107 × 10 −5 , Holm-adjusted p = 2.214 × 10 −5 ; B: Z = 2.904, p = 0.004, Holm-adjusted p = 0.004; G&B: Z = 4.813, p = 1.484 × 10 −6 , Holm-adjusted p = 4.453 × 10 −6 ).
The P -value of the meta-analysis of 3 independent datasets was highly significant (mean OR, 0.4; P =1.11E-05), which indicates that hypercholesterolemia tended to occur in women without adenomyosis.
Finally, a PPI network analysis in the STRING confirmed a highly significant interactions, highlighting the biological interconnectivity of these genes (PPI enrichment p = 1.15e−05) ( Fig. 8I ).
We repeated this analysis removing the 19 known ASD/ID genes ( Supplementary Data 1 ) and observed a reduced but still highly significant signal ( P =1.17 × 10 −5 ) corresponding to an odds ratio of 4.1 (95% CI=2.2–7.0).
Interestingly, when assessing whether the sex of an individual contributes to its methylation level, we found a highly significant sex effect at VM-IAP Rnf157 whereby males are more likely to exhibit higher methylation levels than females (p = 1.20e−5; q = 2.16e−4; Figures 6 G, S5 B, and S5C).
[ 34 ] described significantly lower levels of agalactosylated structures for IgG of the fetus (mean value of 13.1 %) as compared to maternal IgG (mean value of 16.7 %; difference of 3.6 % is statistically highly significant; p = 0.000012; see Table 4 ).
Still, re-analysis of the correlation between BAT volume and LysoPC-acyl C16:1 in discovery population showed that the correlation was still highly significant (p = 1.2 × 10 −5 ) when the BAT negative subject is included.
Assuming the population origin on the coast between NQLD and CQLD, we considered Mackay, the first port of entry for European settlers on the Australian tropical coastlands [ 38 ], and found a highly significant positive correlation between β st and distance from Mackay ( r = 0.91, p = 1.2 × 10 −5 , Figure 2 C).
Moreover, employing k-values from 2020 and 2021 to establish classification functions and 2022 k-values for cross-validation to predict sample classification, a highly significant discrimination ( p = 0.000012) was observed among EVOOs stored at different temperatures.
showed a trendp = 0.000012
Males (0.249 ± 0.023, mean ± 95%CI) showed a trend towards higher BOLD activation than females (0.167 ± 0.028, p = 0.000012 by unpaired two-tailed t -test) when all nodes and subjects were assessed.
Combining data from neuropathological and clinical replication cohorts revealed highly significant associations of all ten GAB2 variants (9.7×10 −11 <p<1.2×10 −5 ) with LOAD.
The 4-GES again predicted OS in a highly significant manner (adjusted p = 1.2 * 10 −05 and adjusted p = 5.6 * 10 −05 for cohorts 1 and 2, respectively; Fig. 2A,B ).
A highly significant protective effect for HLA-A*02 : 01 was observed in females (OR = 0.63, p = 1.21 x 10 −05 ), while no effect was seen in males ( Table 4 ).
The reduced model 2 without the ‘taxon’ term gave a much worse fit to the data, resulting in a highly significant likelihood ratio test (χ 2 = 19.12, 1 df, p -value = 1.228 x 10 −05 ).
This first set of results was obtained with high levels of reproducibility, obtaining highly significant values when the data concerning treatments with R8-PNA-a221 and R8-PNA-a221-MUT are compared (p <0.0000123 in five independent determinations.
Replacing the RTK-RAS amplification with the RTK-RAS-MYC amplification in the Cox regression model controlling clinical features led to an increase of the R -square from 0.165 to 0.173, and both NFE2L2 mutation and RTK-RAS-MYC amplification were highly significant ( P = 1.25e−05 and 5.11e−4, respectively, Supplementary information, Table S16b ).
Among these, the former was also the most significant regulator in the KO group ( p = 5.68 × 10 −9 ), while PHIP was the highly significant and exclusive regulator in the KO group fed with ω-3 PUFA ( p = 1.26 × 10 −5 ).
In SW-1353 cells a highly significant down-regulation by 100 μM diacerein in the expression of cyclin B1 to 0.095 ± 0.03 ( p = 1.28E-05), CDK1 levels to 0.154 ± 0.02 ( p = 9.82E-06), and the CDK2 levels to 0.443 ± 0.12 ( p = 0.002) could be demonstrated.
This analysis confirmed a difference in functional hyperemia dynamics that remained highly significant in response to 40‐sec stimulations (visual, P = 1.28 × 10 −5 ; motor, P = 1.18 × 10 −6 ), but not to 20‐sec stimulations (visual, P = 0.133; motor, P = 0.431).
Moreover, we found a highly significant protective haplotype spanning ∼83 kb from intron 4 to the 3′ end of SNCA ( P = 1.29 × 10 −05 ).
We found that SD indeed led to a highly significant 4.8% loss in body weight (−1.3 ± 0.1 g; paired two-sided t -test; p = 1.3 × 10 −5 ; n = 9; Figure 4 A), despite mice having free access to food.
A meta-analysis of all three cohorts (11,258 individuals) was highly significant ( p = 1.3 × 10 −5 , OR = 7.46).
Two further general population cohorts, KORAF4 and SAPHIR confirmed the association, and a meta-analysis of all three cohorts (11,258 individuals) was highly significant (p = 1.3x10 -5 , OR = 7.46).