Excerpts

There were associations with two SNPs near the olfactomedin-like 2B ( OLFML2B ) gene on Chromosome 1 that approached significance ( p = 9.68 × 10 -7 ).

In addition, rs3831470 ( NADSYN1 ) showed marginally significant association in the mega-analysis ( P =9.68×10 −7 ) and significant association in the meta-analysis ( P =2.6×10 −9 ) ( Table 2 , Supplemental Fig.

A one-sided student T comparison of log-converted molar N/P ratios showed highly significant differences (p = 9.70 × 10 −7 ) between bacteria (geometric mean = 21.0, median = 23.3 mol N / mol P) and viruses (geometric mean = 9.25, median = 9.45 mol N / mol P), respectively.

At the genus level ( Supplementary Figure S3A ), the α-diversity pattern mirrored that of the species level, with all indices showing highly significant overall intergroup differences (Kruskal-Wallis test: all χ 2 ≥ 27.674, P ≤ 9.79 × 10 −7 ).

The results indicated that a cluster of highly significant SNPs represented by Chr2_67754173 ( p = 9.85 × 10 −7 ) was located downstream of Chr2T10180100, a gene encoding an LTP protein.

First, the main effect of stimulus disparity was highly significant (F(2.12, 29.68) = 27.99, p<10 −6 , r = 0.667, S1 Table ) in rANOVA.

We concluded that our finding of 33 cases of positive selection on mitochondrial biogenesis genes is highly significant (simulated P < 10 −6 ) and not caused by an expression or sequencing bias.

Briefly, meta-analyses were considered to be supported by robust evidence if the association was supported by more than 1000 cases, a highly significant association (the random effects model had a P -value ≤ 10 −6 , a threshold that is considered to substantially reduce false positive findings) [ 31 – 33 ], there was absence of high heterogeneity based on I 2 < 50%, the 95% PI excluded the null value, and there was no evidence of small-study effects or excess statistical significance.

A highly significant positive correlation ( R = 0.43, P < 1 × 10 −6 ) between CHK1 and ZEB1 was observed in these breast carcinomas, in which 69% (89 of 129) of the tumors with high ZEB1 expression exhibited high CHK1 expression, and 77% (47 of 61) of the tumors with low ZEB1 expression showed low CHK1 expression ( Fig. 8b ).

The inhibition of each infection by heparin was highly significant ( P < 10 −6 by χ 2 test, comparing infected and uninfected populations).

Note that the difference in PS rates is highly significant ( P < 10 −6 ). 10 μg of protein isolated at 1 h was processed by 8%PAGE/SDS for fluorographic auradiography with PPO.

All other combinations of methods and scenarios had highly significant sensitivity (P < 1.0 × 10 −6 ) and specificity (P < 1.0 × 10 −6 ) compared to the baseline value 0.5, except for sensitivity of Lasso in Scenario 2 (P = 0.90).

Borderline significance (5 × 10 −8 < p < 1 × 10 −6 ) for association with systolic BP was achieved for four index SNPs at four separate loci; there were four SNPs showing borderline significant associations with diastolic BP at four separate loci.

Changes between baseline rest phase and acute mental stress phase were statistically highly significant for all self-assessment measures ( p < 10 −6 , two-tailed Wilcoxon signed-rank test).

The association between Harvard step test and overweight was statistically highly significant (p=0.000001) with odds ratio of 24.65 (C.I. = 9.97; 68.68). 4.

The RR ratio was 0.29 (95% CI 0.18 to 0.48) and was highly significant ( P < .000001).

All 157 SNPs with highly significant associations ( P <1 × 10 −6 ) in this region, were in high linkage disequilibrium with rs188686860 and rs115635831 ( r 2 >0.90), and were located proximal (Hg19: 201,717,014-201,995,860) to the CASP8 gene ( Supplementary Table 15 ).

To find 44 of 46 studies showing a positive risk ratio was very highly significant, P<0.000001.

For BRCA2 both ER and grade were highly significant predictors of mutation status, and the interaction of ER and grade was also quite significant (χ 2 = 28.3, 2 df , P <10 -6 ).

Despite the relatively small sample size, one SNP was identified with a very significant P -value ( P = 5.5*10 -8 ) and several others were identified that were suggestive of significance ( P < 1.0*10 -6 ).

The mortality rate for NH white group also demonstrated an increasing trend from 0.132 to 0.196 from 1999 to 2001 (APC: 22.3406; 95% CI, 4.4622 to 39.741; p < 0.000001), with a rise to 0.286 in the mortality rate from 2001 to 2018 (APC: 2.8652; 95% CI, −3.0608 to 3.5123; p = 0.119176), followed by an increase to 0.414 from 2018 till 2022 (APC: 10.7260; 95% CI, 5.725 to 20.0315; p < 0.000001).

6 a) shows similar performance between the NMF and PCA methods, with a small but highly significant trend towards increased values for the NMF method ( p < 10 − 6 , Wilcoxon Signed-Rank test).

Box 1 Umbrella review evidence rating by strength of association Convincing Highly significant associations (P<10 −6 ) Cases of n >1000 I 2 <50% 95% prediction intervals excluding the null value Largest study nominally significant (P<0.05) No evidence of small study effects No evidence of excess significance bias Highly suggestive Highly significant associations (P<10 −6 ) Cases n >1000 Larg

A Chi-square test showed these differences to be highly significant (χ 2 = 236.6; df = 17; p < 0.000001), confirming that germinated seeds are much more likely to occur on the side to which the ants do not have access.

As expected from the scatter, the correlation is small but highly significant ( F test: F (1,1320) = 246; R 2 = 0.16; p < 10 −6 ).