Excerpts

Similarly, the link from maternal AD liability (ukb-b-14699) to a lower risk of insomnia (ukb-b-3957) remained highly significant with the Weighted Median method ( p = 7.67 × 10 −7 ), However, in line with our multi-method approach to identify potential bias, a significant MR-Egger intercept ( p = 0.008) suggests that substantial some caution is warranted due to potential horizontal pleiotropy.

Spearman correlation analysis revealed a highly significant positive correlation between myeloid cell abundance and CCL3 expression (r = 0.32, p = 7.68 × 10 −7 ), as well as a weaker but statistically significant positive correlation with CCL4 expression (r = 0.15, p = 0.02).

Interestingly, we do find a small but highly significant enrichment of SNPs in the immediate vicinity of motifs known to be associated with recombination in the CEU population (7.9%, p = 7.7 × 10 −7 ) ( Fig. 2, left ; Supplemental Figs.

When compared to the cytoplasm, the difference in the ratios of 1,750 cm −1 and 1,654 cm −1 was also highly significant ( P = 7.8 × 10 −7 , Fig. 6 D ).

Out of these 22 variant sets, 12 were in genes implicated in Mendelian disorders affecting red blood cells (for example EPB42 and TFR2 ; see Supplementary Table 15 ) and an additional five had highly significant associations with red blood cell traits in our data (p ≤ 7.82 × 10 –7 ; Supplementary Table 16 ).

Regression analysis of PC1 scores confirmed that age had no significant impact on sample distribution (coefficient = 0.28; p = 0.43), whereas group was the dominant determinant of separation, with a strong and highly significant coefficient of 81.47 ( p = 7.86 × 10−7) (Supplementary Fig. 2E ).

A highly significant linear correlation was found between the BCG index and mortality during the first month of the pandemic ( r 2 = 0.88; P = 8 × 10 −7 ) ( Fig. 4 E ); indicating that every 10% increase in the BCG index is associated with a 10.4% reduction in COVID-19 mortality.

The top activation areas are predominantly located in the right hemisphere, with highly significant laterality ( p = 8.27 × 10 −7 ) seen in the comparison of left and right hemisphere atlas parcellation region averages.

The SNP (g.48476925C > T) and the 3-bp indel (g.48476943_48476946insGGC) in the upstream region of ACVR2A produced a highly significant signal ( P = 8.32 × 10 −7 ; Fig. 1b , Table 1 ), whereas the 21-bp indel in the 5′-UTR and the SNP in the 3′-UTR of ACVR2A were not associated with ANAI 4 ( P = 0.028 and P = 0.51, respectively).

The correlation between the percentages of CD27 low IFN-γ + cells and the form of lung pathology was highly significant (r = 0.63, p = 8.7×10 −7 ), but it was likely secondary to lung destruction: it appeared only when higher scores were assigned to more destructive TB forms (i.e., tuberculoma – score 1; TB infiltrate – score 2; cavitary TB – score 3; caseous pneumonia – score 4); within a group of patients with the same form of lung TB pathology (e.g., TB infiltrate) the percentages of CD27 low IFN-γ + cells correlated with lung destruction (r = 0.45, p<0.01).

Interestingly, the oxidative phosphorylation pathway, and more specifically, the respiratory chain complex I, was highly significant (Hyper-Geometric test, P=8.74E-7) showing upregulation in primary NSCLC tumors that spread to the brain ( Figure 4B ).

This is a highly significant excess of retroposition events off the X-chromosome (χ 2 = 27.884; df = 2; p = 8.8 × 10 -7 ).

For both newborn cord blood and maternal blood, the enrichment was highly significant ( p = 8.85 × 10 − 7 for newborn cord blood; p = 5.70 × 10 − 13 for maternal blood; Fisher’s exact test, two-sided).

Directly comparing the distribution of RSN states evoked by replay and by stimulus identified a clear differential distribution with highly significant increases in RSN states 1 and 2 ( Figure 2 D; one-sided t test, p = 8.9e–7 for RSN state 1 and p = 1.9e−4 for RSN state 2).

Overall, the reconciled tree contained 44 duplication and 28 deletion events, of which only one duplication but 15 deletions were assigned to socially parasitic lineages, a highly significant difference ( Χ 2 = 24.18, p = 9e−07, df = 1).

Most notable were an increase in dead, sub-G1 cells (from 4.5% to 9.3%, P = 0.00173) in the siNR2F2 treated W-V cells and a highly significant decrease in cells in S-phase in siNR2F2 treated U2OS cells (from 19.5% to 6.6%, P = 9.0e−07) that was accompanied by increases in G1 and G2-M, suggesting a cell cycle arrest (Supplementary Figure S6 ).

In contrast, CSA knockout led to strong decrease of the EGFP expression in comparison to the parental cell line, which was highly significant for both cyclo-dA stereoisomers ( P = 9.0 × 10 −7 for 5′ R - and P = 8.5 × 10 −7 for 5′ S -cyclo-dA, heteroscedastic Student's t -test).

Assessment of API5 revealed a significant association with body mass index (BMI) and a borderline significant association with neutrophil count ( p -value = 9 × 10 −7 ).

Putative retrogenes showed a median Ka/Ks of 0.191 with a highly significant deviation from neutrality (V = 0, p = 9.1 × 10−7).

In contrast, rs187522732, located in the intergenic region between KCNJ3 and NR4A2 , showed a trend toward a significant association (effect size = 0.0713 [SE = 0.0145], P = 9.2 × 10 −7 ) in the discovery phase, but not in the replication phase ( P = 0.51).The combined P value for this variant in the meta-analysis ( P = 8.2 × 10 −6 ) was higher than that in the discovery phase, indicating that this association is likely a false positive.

Specifically, its intercept was highly significant ( p = 9.32 × 10 −7 ).

MANOVA results on the PC scores were highly significant, highlighting the substantial differences between the morphological characters of the two species ( α < 0.001; P = 9.38e-07).

In contrast, the SLA measurements showed highly significant differences ( p = 9.47 × 10 −7 ) Figure 5 , with pairwise comparisons revealing significant differences between T1 and T2 ( p = 0.0000096) and between T2 and T3 ( p = 0.0004509), but no difference between T1 and T3 ( p = 0.5129).

The set of 495 genes overlapped between T98G and SK-N-SH cells showed a highly significant relationship with “Mitochondrial dysfunction” ( P = 9.53E-07), while the set of 196 genes identified only in T98G were less significantly related to “Mitochondrial dysfunction” ( P = 3.90E-03).

As expected, the difference in reporter expression between putative enhancers and negative control regions is highly significant ( P = 9.6 × 10 −7 by two-tailed t -test) ( Fig. 4B ).