Excerpts

The two-way within-subject design ANOVA on WM-GM CNR found a highly significant effect of protocol (F(3,21) = 80.32, p<0.000001) but no significant effect of ROI (F(9,63) = 1.475, p>0.15).

For example, a study involving 1001 patients with a highly significant p values < 0.000001 association between risk factors and outcomes may be classified as class I evidence according to the grading criteria of evidence, while another study with the same results in other aspects but only 1000 patients may be graded as class IV evidence.

In this study, a highly significant ( P < 10 −6 ) and consistent decline was observed with the frequency of consumption. 250 Similarly, another case-control study in Puerto Rico ( n = 314) found that consumption of sofrito (a diet based on garlic and onion) was inversely associated with the occurrence of BC.

Calcium ion binding related loci were sequestered out of modules at a highly significant level (Z-score = −18.1, two-tailed p-value<1e-6), which indicates that unlike more coherently regulated systems, calcium ion binding does not co-express strongly with other genes.

Corresponding studies with 89 Zr-DFO-ZEGFR:2377 resulted in 17.7 ± 0.3% (A431) and 23.8 ± 0.2% (MDA468) cell-associated radioactivity. Pretreatment of A431 and MDA468 cells with EGFR specific antibody cetuximab led to a highly significant (<0.3% of total activity; P < 1 × 10 –6 ) reduction of binding of 89 Zr-labeled affibody bioconjugates indicating highly specific targeting properties ( Figure 3 A).

There was a highly significant time effect, group effect and interaction between time and group ( p < 10 –6 ).

Analysis of the linear model including both species and sex as predictors of fore wing length revealed that this simple model explained much of the variation in size among the cicadas, and that the effects of both predictors were highly significant ( R 2 = 0.805, p < 0.000001 for both variables).

The observed signal for G is statistically highly significant as evidenced by randomization calculations ( P -value < 10 − 6 , Figure 2 B).

The degree of reading impairment in patients, however, was significantly larger for passage than word reading, as evidenced by a highly significant Group (patients, controls) × Test (GORT, WRAT) (F(1,36) = 34.29, p = 10 − 6 ) interaction.

We observed a highly significant reduction in rolling in response to noxious stimuli compared to both controls when we inactivated the nociceptive class IV neurons (Chi square test, p< 10 −6 , Fig. 4A and 4B and Table S1 ) [2] , [29] , [40] .

The intra-correlations of IgE levels among newborn, 1.5, 3 and 6 years were highly significant correlated one another ( P <10 −6 ; Table 2 ).

However, in the presence of added adenosine (3 or 10 μmol/L), guanosine (10–100 μmol/L) decreased proliferation of both cell types, thus resulting in a highly significant ( P < 0.000001) interaction between guanosine and adenosine on cell proliferation.

By calculating the probability that 11 of 36 identified sites should fall in this binding region comprising 20 sites of a total 626 sites by chance ( Methods ), we found the concentration of sites identified as under positive selection in this region to be highly significant ( P < 10 −6 ).

showed a highly significant correlation between final VA and the presence of RD (p <10 -6 ) which makes retinal detachment one of the main limiting factors for a favorable visual outcome ( 6 ).

Kolmogorov-Smirnov test showed this difference to be highly significant (p < 10 −6 ).

2 ), of which two, on chromosomes 3 and 5, are highly significant ( P < 10 −6 ).

The analysis of the heat stress data also revealed that the number of highly significant genes (unadjusted p < 10 −6 ) increased with the number of included experiments.

No SNPs reached genome-wide significance, however four independent SNPs were nominally significant ( P < 1 × 10 −6 ) (Fig. 3 ).

All nominally significant variants from each meta-analysis (p< 1.0 × 10 −6 ) are displayed in Supplementary Table 2 .

Box 1 Umbrella review evidence rating by strength of association Convincing Highly significant associations (P<10 −6 ) Cases of n >1000 I 2 <50% 95% prediction intervals excluding the null value Largest study nominally significant (P<0.05) No evidence of small study effects No evidence of excess significance bias Highly suggestive Highly significant associations (P<10 −6 ) Cases n >1000 Larg

Convergence was obtained for all morphological traits and in all cases the full model accounted for significantly more variance than the constants-only model and this difference was highly significant ( P < 10 −6 ).

Finally, when correlation values were raised to c = -80% and c = +80% highly significant GC values were obtained (Figure 3A , c = -0.8, GC = 1.056, P < 1 × 10 -6 ; Figure 3E , c = 0.8, GC = 1.073, P < 1 × 10 -6 ).

A one-way repeated measures ANOVA confirms that the number of items had a highly significant effect on identification accuracy ( F (3,15) = 42.8, p <0.000001).

Despite the fact that single, silent substitutions can not be detected in the selective system, we observed a highly significant correlation in mutable positions between the in vivo and in vitro spectra (Pearson linear correlation coefficient = 0.79, P<10 −6 ).

Red Jungle fowl × White Leghorn F 2 cross: a worst-case scenario for assessing the effects of covariate uncertainty and nonfixation of QTL within founder lines: In a preliminary model for chicken body weight without QTL effects, estimation of sex effects in a DGLM gave highly significant ( P < 10 −6 ) estimates of 410.0 and 0.509 for mean and variance predictors, respectively.