Excerpts

When both dogs and cats were grouped by age, a clear trend was observed indicating that mammary tumors were more frequent in older cats (χ 2 (4) = 35.43, p = 3.8 × 10 −7 ; Cramér’s V = 0.224; OR/RR + 95% CI).

This difference is highly significant in both species (yeast: p = 3.8 × 10 −07 , human: p = 1.8 × 10 −21 , Wilcoxon one-sided test).

However, this association is highly significant ( p = 3.82E-07).

The waist circumference was higher per minor allele in never-smokers: +0.23% (95% CI 0.09% to 0.36%; p=0.0012), non-significantly related in former smokers −0.07% (95% CI −0.24% to 0.09%; p=0.37) and lower in current smokers −0.40% (95% CI −0.57 to −0.22 p=1.69×10 −5 ): differences among smoking groups were highly significant (p=3.85×10 −7 ; see online supplementary figure S2.

As expected from the relationship between plant times and theta sequences, there was a highly significant temporal modulation of MUA and plant times (5 rats, 61 epochs, 60–100 cm on w-track: t -test: P = 3.9 × 10 −7 ; Extended Data Fig. 4c ).

Combining the data from all cohorts (1232 patients and 5930 controls) resulted in a highly significant association between TAAD and duplications of 16p13.1 ( P = 3.97×10 −7 , OR = 12.6, 95% CI = 4.2–45.3).

In contrast, class II genes showed a significant trend for downregulation relative to ESCs (Kruskal–Wallis test, p = 4 × 10 −7 ).

O) as a fixed factor and the random factors of population and cage yielded a highly significant effect of selection regime on A ( p = 4×10 −7 ) and α ( p = 5×10 −9 ).

Discrepancy scores of normative data compared to sample data indicate a highly significant difference, where the LC sample has a greater score than the healthy population ( Z = 5.07, M COVID = 16.35, M norm = −0.63, p = 0.0000004; Figure 1C ).

Remarkably, we observed highly significant association between the methylation state at cg18181703 and the MetS status in our large cohort ( P = 4.01 × 10 −7 ) ( Table 3 ), suggesting the epigenetic status at this site of gene SOCS3 is strongly inversely associated with the presence of MetS.

The Rao & Scott-adjusted Pearson chi-square test indicated a highly significant effect of age on food purchases driven by security needs (food stocks), F [6.67; 7068.99] = 6.28, p = 4.04 × 10 −7 .

This effect of the random dot condition in the MSB ROI was highly significant (LMM with monkey subjects as random effects (Materials and Methods); p = 4.094e-07; Fig. 8 ).

catp-6(0) mutants present a highly significant smaller brood size when compared to N2 ( Table 1 , group c, ANOVA, Tukey post-hoc test, adj. p -value = 0.000000416).

In this, breed was found to be highly significant ( p = 4.2 × 10 -7 ), expression levels were significant ( p = 0.001), but behavioural trait ( p = 0.27) and interactions were not significant.

Signature performance was driven by the highly significant associations of the arginine/WARS ( p = 4.3 × 10 −7 , τ = 0.43), cortisol/SOCS1 ( p = 7.4 × 10 −6 , τ = 0.28) and 5-oxoproline/LAP3 (5.8 × 10 −5 , τ = 0.37) pairs ( Figure S8 ).

Multiple CpGs reaching genome-wide significance (FDR < 0.05) were found for E2 (87 CpG sites, corresponding p value < 8.36e-06, Supplementary Table S2 ); for PRL (199 CpG sites, corresponding p value < 2.02e-05, Supplementary Table S3 ); and borderline significant for P (3 CpG sites, FDR = 0.06, corresponding p value < 4.30e-07, Supplementary Table S4 ).

Figure 3 shows a highly significant association (log-rank P =4.33e −7 , Cox P =0.0040, HR 0.67, 95% CI 0.51, 0.88) between OS and methylation of MYLK3 , most prominently in totally debulked patients.

Interestingly, among the top 25 associations detected, novel genome-wide marginally significant signals outside chromosome 19 were observed: in chromosome 12 (intergenic: rs249153, p = 4.38×10 −07 , OR = 1.41; intergenic: rs249166 and rs249167, both with p = 6.91×10 −07 and OR = 1.40) and in chromosome 5 (intergenic: rs13178362, p = 6.60×10 −07 , OR = 0.75), followed by trends inside the memb

In contrast, the 100-gene PDCD4 signature demonstrated highly significant prognostic value (HR = 0.63, 95% CI: 0.53–0.75, p = 4.5 × 10 −7 , C-index = 0.621; Supplementary Figure S3 ), with significantly superior discriminative ability (likelihood ratio test p < 2.2 × 10 −16 ).

The overall survival (OS) curve showed a clear trend, with patients classified in the high-risk group based on the risk scores experiencing increased mortality risk and shorter survival times ( p = 4.5e-7, HR = 2.66) ( Figure 5D ).

The difference between 7m (15%) and V6A (3.1%) is highly significant ( p = 4.5 × 10 −7 ; z = 5.0; ratio test), reinforcing the conclusion that the “home ground” for background-centric neurons is located in 7m/PGm, the genuine region of the precuneus.

They identified 10 SNPs in the GRB-associated binding protein 2 ( GAB2 ) gene on chromosome 11q14.1 with nominally significant associations ( P = 4.56 × 10 -7 to 8.92 × 10 -5 ) in the APOE ε4 carrier subset of the neuropathological discovery cohort composed of 299 LOAD patients and 61 controls.

An analysis of gene expression considering all genes and DGRP lines revealed a highly significant five-way interaction among injury, diet, age, gene, and line (ANOVA, F 144,2736 = 1.72, P = 4.58 × 10 −7 ), with interaction meaning that the effect of one factor on gene expression depends on the level(s) or one or more other factors.

The differences in FB-E miR-9 levels between the EtOH and control groups were highly significant ( p = 0.000000464825; Figure 6 A). *** p < 0.001.

Of note is that one of the DPA1∼DPB1 haplotypes (DPA1*01:03∼DPB1*04:01) is associated with protection and highly significant ( p = 4.76 × 10 −07 ).