Excerpts

Regarding the NSVB, there were highly significant differences between Hap1 and Hap2 ( P = 3.02e‐07) as well as between Hap2 and Hap4 ( P = 4.70e‐03), but there was no significant difference between Hap2 and Hap3 (Figure S5 ).

Particularly, the difference in a* among the 7 haplotype combinations was highly significant ( P = 3.06E-07), and the average of a* values were significantly lower in the pigs with the 11 and 13 haplotype combinations than those with 12 and 14 haplotype combinations.

However, there was a highly significant correlation between high FLAP expression and lower overall probability of survival in the 720 patients with lung adenocarcinoma ( P = 3.1 × 10 -7 , HR = 1.86) (Figure 1C ).

This SNP also exhibited a highly significant association with gestational age at delivery ( P = 3.1 × 10 −7 ).

The strongest iHS signals were detected on the X chromosome in SAR_M, where two closely spaced intergenic SNPs showed highly significant values (−log P value > 6.5) at approximately 44.6 Mb ( Figure 1 ).

Using this combination of methods, highly significant ( P <3.17×10 −7 ) population-specific sweeps pointing out to candidate genes and pathways that may be involved in beef and dairy production were identified.

We observed a highly significant shift in the distribution from expectation (p = 3.27x10 -7 ).

( 23 ) and another two SNPs were nominally significant including rs11556924 ( p = 3.3e-07, locus 10) and rs2980853 ( p = 3.5e-05, locus 11). 3.2.3.

2 ), all but four (rs61190714, rs4387605, rs12031924 and rs57892111) were significant in the main GWAS and, of these four, three were in LD with an SNP that approached significance ( P < 3.3 × 10 −7 or smaller) in the main analysis.

For the average ratio of the number of hospitals and hospital beds, the public sector exhibited a negative, moderate, and statistically significant trend (τ = −0.400, p = 0.0122), whereas the private sector showed a positive, highly significant trend with excellent strength (τ = 0.809, p = 3.338 × 10 −7 ).

3 RESULTS 3.1 Lesion healing scores There was a highly significant Treatment × Day interaction ( p = 3.4 × 10 –7 ), indicating differing lesion healing score time courses across the three treatment groups.

These two highly significant SNPs (rs10842383 near LINC00477 , P =3.45 × 10 −7 and rs2680344 in HCN4 , P =4.34 × 10 −7 ( Supplementary Table 12 ) had large opposite effects on atrial fibrillation, while both decreased HRV.

When PFS was compared between these two subgroups, we found a highly significant difference (Cox p = 3.46e-07, hazard ratio (HR) = 6.7; Fig. 2 a).

When applied to analysis of genetic homogeneity, blacklists allowed identification of highly significant STAT1 enrichment in 209 patients with chronic mucocutaneous candidiasis (p = 3.46x10 -7 ).

In contrast, when ESS was present, there was a highly significant association between comorbidities and death (Fisher’s exact test, p = 0.00000035).

One-way analysis of variance (ANOVA) indicated that fiber content had a highly significant effect on the peak stress of the specimens (F(4,10) = 68.71, P = 3.58 × 10 − 7).

The poor survival by high fetuin-A expressing tumor cells was highly significant in poorly differentiated gastric tumor cells (overall survival log rank P = 3.6 × 10 -7 ) [ 60 ].

The association between this SNP and HDL-C levels is weak when considering only allelic variation ( P = 0.98) but becomes highly significant when evidence from the genotype and the estimate of local ancestry is combined ( P = 3.6×10 −7 ) ( Table 4 ).

This identified 82 significantly enriched GO terms ( Table S3 ) spanning broad aspects of plant biology, of which the top 25 Biological Process terms are presented in Figure 3 A, including highly significant categories such as cellular process (GO:0009987; adjusted p = 3.6 × 10 −7 ), metabolic process (GO:0008152; adjusted p = 9.9 × 10 −6 ), biological process (GO:0008150; adjusted p = 1.3 × 10 −5 ), and cellular metabolic process (GO:0044237; adjusted p = 2.0 × 10 −4 ).

Several immuno-active genes demonstrated highly significant correlations between methylation and gene expression in IBD, in particular OSM: IBD r = −0.32, p = 3.64 × 10 −7 vs non-IBD r = −0.14, p = 0.77].

As a result, the scoring system by the combination of features with the top five highest absolute values of importance was highly significant (P-value = 3.692e−07) and a reasonably simple equation in the order of early-CRT Monocyte count , Distance from anal verge , early-CRT PLT , early-CRT Neutrophil count , and early-CRT Eosinophil count (Equation 5) was formed.

We took advantage of the fact that 72 of the GII bulls had non-overlapping sets of GIII sons in H and NZ, to estimate the repeatability of GRR as the correlation between these independent measurements, yielding a highly significant Spearman's correlation coefficient of 0.58 (p<3.7×10 −7 )( Figure S4B ).

Further comparisons of telomere length in leukocyte subsets as a function of gender showed highly significant differences between males and females in the CD45RA+CD20− “naïve” T lymphocyte subset over the entire age range (F(4,825) = 9.05; P = 3.7×10 −7 , ANOVA test result comparing regression fits; Figure 3B and Table S5 ).

There was a highly significant enrichment of methylation changes around GWAS single nucleotide polymorphisms ( P = 3.7 × 10 −7 ), notably the HLA region and MIR21 .

Expression heterogeneity of CD63 was found to be highly significant on this cell trajectory ( p -value = 3.755 × 10 −7 , Supplemental Table S3 ) and defined a green trajectory cluster ( Figure 6 D) comprising markers like cluster of differentiation 52 (CD52), heat shock protein family B (small) member 1 (HSPB1), Meis homeobox 1 (MEIS1), Pim-2 proto-oncogene, serine/threonine kinase (PIM2), RAD52 homolog, and DNA repair protein (RAD52) following CD63 expression ( Figure 6 E).