Excerpts

8 , highly significant effects were observed for the factors of eccentricity ( F (1,5) = 2458.257, p = 10 −7 ), and visual area ( F (1.574,7.871) = 107.981, p = 10 −5 , Greenhouse-Geisser corrected), and a significant interaction was found between these two factors ( F (3,15) = 85.102, p = 10 −8 ).

The student’s t test showed that the differences in mean levels of expression in the 2 groups in arrays were highly significant; for 483-3p, p=0.0000001 and for 548e-3p = 0.0009482.

Autophagy genes, including DAPK3 and ULK1, which were previously shown to be DAXX repression targets [Submitted], were found to be closer to DAXX ChIP-Seq peaks than all other genes combined (Figure 3 ), implying that they are very likely to be regulated by DAXX (with the difference being highly significant: p < 10 −7 ).

Only the mastectomy GWAS failed to yield nominally significant SNP hits ( P <10 −7 ).

Mutants of ERG6 , which encodes a protein in the ergosterol biosynthetic pathway, had the greatest sensitivity to the extract, and this was a highly significant response ( P < 1e‐7).

Between the measurements from the devices, there was a difference of 73 μm in the central zone and 43–50 μm in the parafoveal zones This difference between these absolute measurements was highly significant in all zones ( p < 1 × 10 −7 ).

Highly significant correlations between age and clinical response (t = 5.75, df = 149, r = 0.43, p<10 −7 , older patients responded better), as well as age and total brain volume (t = −7.32, df = 149, r = −0.51, p<10 −10 ) were also observed.

A paired-sample t test was highly significant ( t (20) , p < 0.0000001).

This is likely the case for many trans -eQTLs of marginal significance (5×10 −9 <P<10 −7 ), which are less likely to be cis -eQTLs than FDR-significant trans -eQTLs.

In a set of ubiquitously expressed housekeeping genes ( n =374), a highly significant positive correlation between expression and the mutational bias (B) (r=0.28; P <10−7) was reported 24 .

There was a highly significant difference (P< 10-7) between the two groups of patients.

These QTLR presented among the most significant associations in the first scan, and still harbor highly significant associations (p < 1e−7 and 1e−8, respectively).

Statistical analysis carried out on the timing errors, pooled over all subjects after averaging over all repetitions of each condition (four-way ANOVA, 3 [viewing distance] x 5 [ball descent duration] x 2 [figure type] x 6 [character type]), showed highly significant effects of character type ( F 5,1168 = 113.188, P <10 −7 ) and figure type ( static versus dynamic , F 1,1168 = 25.180, P <10 −6 ), less significant effects of viewing distance ( F 2,1168 = 3.602, P <0.05) and of the interaction between character type and figure type ( F 5,1168 = 2.569, P <0.05).

The correlation between fluorescence and bone vitality was highly significant ( p < 0.0000001).

In all cases R was >0.90 and all correlations were highly significant (10 −12 < P < 10 −7 ).

In this case, the first two PCs were highly significant, namely a Tracy-Widom test P-value <10 −7 , but the additional lower ranked PCs (third and onwards) had P-value larger than 0.05.

For AMD, we identified one genome-wide significant locus in 18q22.2, rs12956753 (OR = 1.71, p = 3.76 × 10 −8 ), and another nearly significant locus in 15q14, rs138597498 (OR = 1.75, p = 1.02 × 10 −7 ), located near the genes DOK6 and DPH6 , respectively ( Figure 1 B).

The median mutation count was lower in the H/L cohort compared to the NHW cohort, with a highly significant p -value ( p = 1.02 × 10 −7 ), suggesting potential differences in genomic instability between these populations.

In total, we found a significant trend of gene number decrease in these independent mangrove clades ( Fig. 2 ; Wilcoxon signed-rank test; P = 1.04 × 10 −7 ).

They were highly significant in the Dutch sample (rs12472355; OR, 1.39, CI 1.23–1.57, p = 1.05×10 −7 and rs919433; OR 1.43, CI 1.26–1.61, p 9.77×10 −9 ), and in the meta-analysis of all three samples they reached genome-wide significance ( Table 2 ).

Specifically, target genes of miR-30a-5p, miR-486-5p, miR-30c-2-5p, miR-205-5p, and miR-106b-3p whose expression levels showed a trend from healthy controls to MIBC patients displayed an over-representation in several KEGG pathways such as “Pathways in cancer_Homo sapiens” (hsa05200; adj p = 1.05 × 10 –7 ), “MicroRNAs in cancer_Homo sapiens” (hsa05206; adj p = 2.97 × 10 –7 ) and “Bladder cancer_Homo sapiens” (hsa05219; adj p = 3.38 × 10 –5 ).

GO analysis found that GO:0016236 was involved in autophagy, while KEGG analysis revealed a highly significant ( P = 1.06E-07) new pathway, hsa04216 (ferroptosis), a new cell death pattern associated with iron death.

We found a highly significant positive correlation between these 2 estimators of the pairwise V ST statistic (Pearson's test, P = 1.06e−07; supplementary fig.

Secondary Analysis of GWAS Finding In our study, the variant rs4242007 was in near-complete linkage disequilibrium ( r 2 = 0.98) with rs4074555 (chr4:57110400, C/A), which itself approached significance in the primary GWAS ( p = 1.07 × 10 −7 ).

Furthermore, data from seven studies demonstrated highly significant positive association between telomere length and spirometric measurements including FEV 1 (β=0.0455, p=1.07×10 −7 with fixed and random effects; I 2 =0%), FVC (β=0.0401, p=2.07×10 −7 with fixed and random effects; I 2 =0%), and FEV 1 /FVC (β=0.0238, p=5.27×10 −7 with fixed and random effects; I 2 =0%) 25 .