Excerpts

Interestingly, mass spectrometry analysis revealed that differentiation of Nsd1 -expressing Nsd1 −/− erythroblasts was associated with a highly significant reduction (logFC = −1.96; p < 1.08 × 10 −7 ) of the transcriptional repressor protein SKI previously proposed to interact with and inhibit GATA1 activation, most likely in cooperation with the nuclear co-repressor (NCoR) complex (Fig. 8g, h , Supplementary Fig. 6d ) 43 , 44 .

The highly significant correlation between percentage of reference assembly recovered in end-tagged contigs and the percentage of “reference proteins” annotated (R 2 = 0.98, p -value = 1.096e-07) strongly suggests that contiguity of assembly - rather than fundamental differences in annotation quality by different methods – determines reference protein discovery in this experiment.

For D8-D1 freezing bouts, the Treatment x Strain interaction was not significant [ F (1, 180) = 2.2; p = 0.14]; however, NAL-trained J mice clearly demonstrated a highly significant increase in the number of freezing bouts relative to SAL-trained J mice [ t (98) = 5.8; p = 1.1 × 10 −7 ] and relative to NAL-trained NJ mice [ t (85) = 4.2; p = 7.0 × 10 −5 ].

However, during the incubation period, their proportion increased on plant leaves (4–17%) and even highly significant in the case of samples from surrounding abiotic surfaces (0–25%; two-way ANOVA P = 1.1 ∗ 10 -7 ).

In complete contrast, no bias ( p = 0.92, two-sided binomial test) is seen for all multiple-SNP tracts combined, and the difference relative to single-SNP tracts is highly significant ( p = 1.1 × 10 −7 , Fisher’s exact test).

There was only one highly significant gene identified ( ACTG2 ( p = 1.1 × 10 −7 )) from the assembled alleles (Fig. 1 D and Supplementary Table S 5 ).

After correcting for multiple testing ( p -values ≤ 0.0167 considered as significant), multivariable linear regression models revealed a significant interaction between APOE4 and NFT density regarding the association with pS65-Ub level in the hippocampus (interaction p = 0.0078); though highly significant in both groups, the magnitude of this association was much stronger in carriers of APOE4 (β: 0.66, p = 1.10 × 10 –7 ) than in non-carriers (β: 0.38, p = 1.16 × 10 –7 ) (Fig. 2 a, Supplementary Table 1).

A ) Cis -eQTL SNPs were located nearer H3K4me3 peaks in CD4 T EM cells than the 159 top SNPs that did not reach statistical significance at 5% FDR ( p = 1.10×10 −7 , one-sided Mann-Whitney test).

Indeed, we found a highly significant positive correlation in changes in RNA levels in these comparisons ( Fig. 6 A , p -value < 1.1E-07).

PA6 rM content had a highly significant effect on DIC development (Fig. 2 ; 1-way ANOVA; n = 9, g = 3, df = 2; F = 33.59, p = 1.13 × 10 −7 ).

This increase in firing due to heptanal 1% relatively to mineral oil was highly significant (V = 17, p = 1.171*10 −7 and V = 7, p = 3.03*10 −9 ).

The Pearson correlation coefficient for the model predictions versus Months to Progression of -0.75 is highly significant (p = 1.19e-7).

The Kruskal-Wallis test of correlation between genome size and chromosome number was highly significant with p = 1.196E -07 .

Analysis of the previously reported IHC and MSI statuses of these samples ( Table 1 ) confirmed there was a difference in assay concordance between Ohio and Manchester cohorts (18%) that was highly significant ( p = 1.2 × 10 −7 ).

For both phenotype traits, highly significant p -values ( p = 1.2×10 −7 for BMI and p = 4.8×10 −10 for type 2 diabetes) were attained for rs1421085, which belonged to LD cluster 3, while the other assayed SNPs except for rs9941349 showed almost equivalent levels of significant association in Asians ( Table 1 and Table S2).

The relative risk (RR 95%) of having a infection was highly significant: RR = 6,8 (3.314154 -13.95228) (P= 1.235e-07) and also neuroinfections RR = 4,76 (2.043019 - 11.09025) ( P = .00044478) if the child presented MMC wound CSF leakage before VP shunt insertion.

The association at rs2735591 is highly significant in the combined validation samples ( P = 1.27 × 10 −7 , OR = 1.27), even after correction for all the 4363 SNPs tested in the current study ( P corrected = 5.54 × 10 −4 ) and surpassed the genome-wide significance threshold ( P = 1.03 × 10 −9 , OR = 1.24) in the combined GWAS and two independent validation series, consisting of a total of 3148 cases and 7843 controls (Table 2 ).

Most strikingly, an independent analysis identified a highly significant overlap in the differentially expressed set of genes: the correlation between the expression ratios in the two studies was 0.57, with a corresponding of P = 1.27×10 −7 .

MDV infection induced a highly significant increase in H3K4me3 enrichment in the promoter region of MX1 in both lines (line 6 3 : p = 1.28x10 -7 , line 7 2 : p = 4.26x10 -9 ; Figure 2 A).

Importantly, comparing genes differentially expressed in NPM1c/FLT3 -ITD mutated human AML 19 with our differentially expressed genes between DM and WT HSPC, we could demonstrate a highly significant overlap with 27% up- (119/441, p =1.28e-07) and 15% (74/503, p =1.27e-07) of downregulated human genes also evident in our dataset Figure 1h ).

For instance, the MEblack module showed a highly significant negative correlation with the pelargonidin-related trait (r = −0.972, p = 1.29e−7), suggesting that genes within this module may be negatively associated with pelargonidin accumulation.

Another site in the same gene was significant for HOMA-IR and of borderline significance for insulin ( P = 1.29 × 10 −7 and P = 3.36 × 10 −6 , respectively).

rs1456315 was found to be marginally significant in the African American GWAS ( P = 1.29 × 10 −7 ). rs1456315 and rs72725879 are linked ( r 2 = 0.815) in the Japanese American GWAS population and have similar allele frequencies across East Asian populations while rs1456315 and rs72725879 are less linked ( r 2 = 0.448) in the African American GWAS population and have divergent allele frequencies across African populations ( Fig 2 ). r 2 values between SNPs were calculated using PLINK in each individual case-control study.

The nonsense variant showed a highly significant association with white spotting ( P = 1.3 × 10 −7 ; Table 1 ).

Variants within LIPC (lipase hepatic, 15q21-q23) associated with HDLC-GLUC, ( rs2043085 , P = 1.3E-08) and with WC-HDLC ( rs10468017 , P = 5.5E-08); ABCB11 (ATP-binding cassette, subfamily B [MDR/TAP], member 11, 2q24) associated with HDLC-GLUC ( rs569805 , P = 8.5E-08); TRIB1 (tribbles homolog 1 [ Drosophila ], 8q24.13) variants were associated, respectively, with HDLC-TG ( rs2954026 , P = 7.9E-09) and TG-BP ( rs2954033 , P = 8.5E-09); and TFAP2B (transcription factor AP-2 β [activating enhancer binding protein 2 β], 6p12) was associated at a borderline significance level with WC-GLUC ( rs2206277 , P = 1.3E-07).