Excerpts

Initial data analysis of SUDHL2 dataset failed to detect GLUT1 and HK2 because of the highly significant pre-established criteria set for RNA enrichment co-correlation analysis.

Functional analysis of the differentially expressed mRNAs In evaluating the top differentially expressed mRNAs (n = 250), we found a highly significant enrichment for several functional annotations (Supplemental Fig. 5 ), including acetylation (genes post-translationally modified by the attachment of at least one acetyl group; n = 85 genes; Fold enrichment = 2.2; Bonferroni-adjusted p = 4.2 × 10 −11 ), mitochondrion (the site of tissue respiration

In the multivariable-adjusted model, those in quartile 3 had lower odds of severe DR or worse versus the combined no DR and minimal-moderate DR categories, than those in quartile 1 (OR, 0.35; 95% CI: 0.17 to 0.74; P = 0.006; per categorical increase in severity Model 2 in Table 2 ), and a significant trend for increasing frequency of fish consumption (P-trend = 0.024).

The maximum loading rates under different preset pressure are listed in Table 1 , where an increasing trend can be observed.

4a are not able to show a clear trend, in Fig. 4b we reported the comparison between the number of cells undergoing the power-law behavior and the number of cells showing behaviors ascribable to active mechanics (oscillatory, saltatory or immediate retraction) as a function of the incubation time.

However, if saturated and unsaturated fatty acids were entered simultaneously into a multivariable model, each was a highly significant predictor (Combined model 1, Table 2 ).

All pairwise comparisons showed highly significant Fst-values (range = 0.081–0.096), confirming the significant discriminatory power of the random forest detected SNP subset.

The REACH-Pilot study comprised of 7 patients showed a trend towards improvements in 6-min walk distance and diuretic use 36 .

3d and the inset), the engineering stresses of grey matter after storage of 0 h, 1 h and 4 h are 1.06 ± 0.41 kPa, 0.93 ± 0.24 kPa and 0.69 ± 0.14 kPa (mean ± s.d.), respectively, indicating a decreasing trend in the engineering stress of grey matter due to the prolongation of storage duration.

H 2 values of growth rates (dynamic traits) showed an increasing trend until reaching maximal levels (>0.7) in the middle of the growing season (DAP 65 to 72 or DAP 72 to 87).

Moreover, there seems to be an associative trend between NT-proBNP level and overall contour change of the arterial reflection wave, both of which can be due to RAS alteration, even in a short-term ARBs administration.

The results concerning the female hind legs can be summarized as follows: i) only the cortical bone of the tibiae was responsive to the SIT and showed alterations in the Cs.Th., ii) these alterations included a transient and not quite significant decrease after four weeks of SIT, iii) a very significant increase after eight weeks of SIT with iii) changes occurred at both, endosteal and periosteal surfaces with an emphasis on the distal half of the tibiae.

Beta-diversity analysis Average beta-diversity values were similar among years for the whole community (arithmetic mean ± SE: 0.419 ± 0.059 for 1997; 0.467 ± 0.070 for 2005; 0.444 ± 0.043 for 2012) and for the stygobiotic species (0.526 ± 0.065 for 1997; 0.632 ± 0.072 for 2005; 0.633 ± 0.049 for 2012; difference between 1997 and 2012 is in fact marginally significant), whereas increased significantly after the earthquake for the non-stygobites (0.340 ± 0.048 for 1997; 0.323 ± 0.044 for 2005; 0.535 ± 0.043 for 2012) (Table 3 ).

3D reconstructions show a decreasing trend in trabecular bone with no apparent changes in cortical bone (Fig. 2a ).

The results of the current study showed a decreasing trend of the constituent ratio of Q1, Q2, Q3, and Q4 in the PA3 group and an increasing trend in the constituent ratio of Q1, Q2, Q3, and Q4 in the PA1 and PA2 groups; no significant difference was shown in the distribution of AIP quartiles between the PA1 and PA2 groups.

34 , who studied on changes of intestinal microbiota of enteritis host, and the highly significant increase of the abundance of Ruminococcus was related closely to enteritis.

Although the effect is highly significant for a detailed understanding of the time dependence of the low-energy spectra, a factor of 1.5 is hardly visible in the logarithmic plot of our Fig. 1 , where it just leads to a shift of the data that has the same order of magnitude as the symbol size, given the logarithmic scale of the figure.

Instead of an arbitrary choice of a p-value threshold 30 , we argue that only voxels contributing positively to model performance should be considered practically significant.

The response of C 38 alkenones to cold stress showed a trend similar to that of C 37 alkenones during 7 days (Fig. 2 , Table S1 ).

Engagement of CD134 on human NK cells with an agonistic mAb increased ADCC capacity, IFNγ secretion and showed a trend towards greater TNFα release.

In this case the trypan blue exclusion assay showed a trend toward lovastatin inducing cell death, but did not reach statistical significance (p = 0.18).

The ratio of GSSG to GSH in liver also showed a trend of decrease by CANA treatment (Supplementary Figure 5b ).

The four phyla showed more or less significant differences between months, which could be interpreted according to temperature and humidity changes.

Regarding the independent FCs, in the southern province the FCs III, IV, V and VI were significantly correlated with the δ 18 O value, while in the northern province only the FC III was significantly correlated and correlations with FC V and FC VI were marginally significant (Table 3 ).

Of note, APC depletion led to a highly significant reduction in frequency of CD8 + IFNγ + T cells in ischemic grafts as compared to non-depleted ischemic grafts (compare to Fig. 2D ) (0.12 ± 0.02% vs. 27.7 ± 2.46%, *** p < 0.001).